| Title: |
Evaluation of coagulation disorders and iron deficiency in women with heavy menstrual bleeding |
| Authors: |
Rugeri, Lucia; Fruchou, Yelena; Brodbeck, Caroline; Bastien, Marianne; Lioux, Amandine; Gouy, Giulia; Cortet, Marion; Dubernard, Gil; Dargaud, Yesim |
| Source: |
International Journal of Gynecology & Obstetrics ; ISSN 0020-7292 1879-3479 |
| Publisher Information: |
Wiley |
| Publication Year: |
2025 |
| Collection: |
Wiley Online Library (Open Access Articles via Crossref) |
| Description: |
Objective To explore the incidence of congenital bleeding disorders (CBD), which may result in anemia, in a large cohort of women referred for heavy menstrual bleeding (HMB) in a specialized gynecologic unit. Methods Between January 2022 and January 2024, all women referred for HMB were screened. All benefited from Higham and ISTH‐BAT scoring to assess the importance of blood loss. Gynecologic ultrasound was performed and antecedents were recorded. Standard coagulation tests, complete blood count, hemoglobin, ferritin, and C‐reactive protein assays were performed. Results Among 454 women, medical history disclosed eight cases of CBD (six von Willebrand diseases, one case of FVII deficiency and a CBD carrier). In the 446 others, coagulation tests identified 41 (9.2%) with von Willebrand Factor deficiency (VWF:GPAbR ≤ 50 IU/dL), very severe in three cases (0.7%). Overt anemia (hemoglobin ≤120 g/L) was found in 155 (34.7%) women, and low ferritin ( |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1002/ijgo.70352 |
| Availability: |
https://doi.org/10.1002/ijgo.70352; https://obgyn.onlinelibrary.wiley.com/doi/pdf/10.1002/ijgo.70352 |
| Rights: |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Accession Number: |
edsbas.9E9B5E2F |
| Database: |
BASE |