| Title: |
Post-Covid-19 Irritable Bowel Syndrome |
| Authors: |
Marasco G; Cremon C; Barbaro MR; Cacciari G; Falangone F; Kagramanova A; Bordin D; Drug V; Miftode E; Fusaroli P; Mohamed SY; Ricci C; Bellini M; Rahman MM; Melcarne L; Santos J; Lobo B; Bor S; Yapali S; Akyol D; Sapmaz FP; Urun YY; Eskazan T; Celebi A; Kacmaz H; Ebik B; Binicier HC; Bugdayci MS; Yağcı MB; Pullukcu H; Kaya BY; Tureyen A; Hatemi İ; Koc ES; Sirin G; Calıskan AR; Bengi G; Alıs EE; Lukic S; Trajkovska M; Hod K; Dumitrascu D; Pietrangelo A; Corradini E; Simren M; Sjölund J; Tornkvist N; Ghoshal UC; Kolokolnikova O; Colecchia A; Serra J; Maconi G; De Giorgio R; Danese S; Portincasa P; Di Sabatino A; Maggio M; Philippou E; Lee YY; Salvi D; Venturi A; Borghi C; Zoli M; Gionchetti P; Viale P; Stanghellini V; Barbara G; GI-COVID19 study group |
| Contributors: |
Marasco G; Cremon C; Barbaro Mr; Cacciari G; Falangone F; Kagramanova A; Bordin D; Drug V; Miftode E; Fusaroli P; Mohamed Sy; Ricci C; Bellini M; Rahman Mm; Melcarne L; Santos J; Lobo B; Bor S; Yapali S; Akyol D; Sapmaz Fp; Urun Yy; Eskazan T; Celebi A; Kacmaz H; Ebik B; Binicier Hc; Bugdayci M; Yağcı, Mb; Pullukcu H; Kaya By; Tureyen A; Hatemi İ; Koc E; Sirin G; Calıskan Ar; Bengi G; Alıs Ee; Lukic S; Trajkovska M; Hod K; Dumitrascu D; Pietrangelo A; Corradini E; Simren M; Sjölund J; Tornkvist N; Ghoshal Uc; Kolokolnikova O; Colecchia A; Serra J; Maconi G; De Giorgio R; Danese S; Portincasa P; Di Sabatino A; Maggio M; Philippou E; Lee Yy; Salvi D; Venturi A; Borghi C; Zoli M; Gionchetti P; Viale P; Stanghellini V; Barbara G; GI-COVID19 study Group |
| Publication Year: |
2023 |
| Collection: |
Università degli Studi di Brescia: OPENBS - Open Archive UniBS |
| Subject Terms: |
COVID-19irritable bowel syndrome |
| Description: |
Objectives The long-term consequences of COVID-19 infection on the gastrointestinal tract remain unclear. Here, we aimed to evaluate the prevalence of gastrointestinal symptoms and post-COVID-19 disorders of gut-brain interaction after hospitalisation for SARS-CoV-2 infection. Design GI-COVID-19 is a prospective, multicentre, controlled study. Patients with and without COVID-19 diagnosis were evaluated on hospital admission and after 1, 6 and 12 months post hospitalisation. Gastrointestinal symptoms, anxiety and depression were assessed using validated questionnaires. Results The study included 2183 hospitalised patients. The primary analysis included a total of 883 patients (614 patients with COVID-19 and 269 controls) due to the exclusion of patients with pre-existing gastrointestinal symptoms and/or surgery. At enrolment, gastrointestinal symptoms were more frequent among patients with COVID-19 than in the control group (59.3% vs 39.7%, p < 0.001). At the 12-month follow-up, constipation and hard stools were significantly more prevalent in controls than in patients with COVID-19 (16% vs 9.6%, p=0.019 and 17.7% vs 10.9%, p=0.011, respectively). Compared with controls, patients with COVID-19 reported higher rates of irritable bowel syndrome (IBS) according to Rome IV criteria: 0.5% versus 3.2%, p=0.045. Factors significantly associated with IBS diagnosis included history of allergies, chronic intake of proton pump inhibitors and presence of dyspnoea. At the 6-month follow-up, the rate of patients with COVID-19 fulfilling the criteria for depression was higher than among controls. Conclusion Compared with controls, hospitalised patients with COVID-19 had fewer problems of constipation and hard stools at 12 months after acute infection. Patients with COVID-19 had significantly higher rates of IBS than controls. |
| Document Type: |
article in journal/newspaper |
| File Description: |
ELETTRONICO |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/36591612; info:eu-repo/semantics/altIdentifier/wos/WOS:000920725300001; volume:72; issue:3; firstpage:484; lastpage:492; numberofpages:9; journal:GUT; https://hdl.handle.net/11379/575030 |
| DOI: |
10.1136/gutjnl-2022-328483 |
| Availability: |
https://hdl.handle.net/11379/575030; https://doi.org/10.1136/gutjnl-2022-328483 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.9EDEEE73 |
| Database: |
BASE |