| Title: |
Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits |
| Authors: |
Randall, JC; Winkler, TW; Kutalik, Z; Berndt, SI; Jackson, AU; Monda, KL; Kilpeläinen, TO; Esko, T; Mägi, R; Li, S; Workalemahu, T; Feitosa, MF; Croteau-Chonka, DC; Day, FR; Fall, T; Ferreira, T; Gustafsson, S; Locke, AE; Mathieson, I; Scherag, A; Vedantam, S; Wood, AR; Liang, L; Steinthorsdottir, V; Thorleifsson, G; Dermitzakis, ET; Dimas, AS; Karpe, F; Min, JL; Nicholson, G; Clegg, DJ; Person, T; Krohn, JP; Bauer, S; Buechler, C; Eisinger, K; DIAGRAM Consortium; Bonnefond, A; Froguel, P; MAGIC Investigators; Hottenga, JJ; Prokopenko, I; Waite, LL; Harris, TB; Smith, AV; Shuldiner, AR; McArdle, WL; Caulfield, MJ; Munroe, PB; Grönberg, H; Chen, YD; Li, G; Beckmann, JS; Johnson, T; Thorsteinsdottir, U; Teder-Laving, M; Khaw, KT; Wareham, NJ; Zhao, JH; Amin, N; Oostra, BA; Kraja, AT; Province, MA; Cupples, LA; Heard-Costa, NL; Kaprio, J; Ripatti, S; Surakka, I; Collins, FS; Saramies, J; Tuomilehto, J; Jula, A; Salomaa, V; Erdmann, J; Hengstenberg, C; Loley, C; Schunkert, H; Lamina, C; Wichmann, HE; Albrecht, E; Gieger, C; Hicks, AA; Johansson, A; Pramstaller, PP; Kathiresan, S; Speliotes, EK; Penninx, B; Hartikainen, AL; Jarvelin, MR; Gyllensten, U; Boomsma, DI; Campbell, H; Wilson, JF; Chanock, SJ; Farrall, M; Goel, A; Medina-Gomez, C; Rivadeneira, F; Estrada, K; Uitterlinden, AG; Hofman, A; Zillikens, MC; den Heijer, M; Kiemeney, LA; Maschio, A; Hall, P; Tyrer, J; Teumer, A; Völzke, H; Kovacs, P; Tönjes, A; Mangino, M; Spector, TD; Hayward, C; Rudan, I; Hall, AS; Samani, NJ; Attwood, AP; Sambrook, JG; Hung, J; Palmer, LJ; Lokki, ML; Sinisalo, J; Boucher, G; Huikuri, H; Lorentzon, M; Ohlsson, C; Eklund, N; Eriksson, JG; Barlassina, C; Rivolta, C; Nolte, IM; Snieder, H; Van der Klauw, MM; Van Vliet-Ostaptchouk, JV; Gejman, PV; Shi, J; Jacobs, KB; Wang, Z; Bakker, SJ; Mateo Leach, I; Navis, G; van der Harst, P; Martin, NG; Medland, SE; Montgomery, GW; Yang, J; Chasman, DI; Ridker, PM; Rose, LM; Lehtimäki, T; Raitakari, O; Absher, D; Iribarren, C; Basart, H; Hovingh, KG; Hyppönen, E; Power, C; Anderson, D; Beilby, JP; Hui, J; Jolley, J; Sager, H; Bornstein, SR; Schwarz, PE; Kristiansson, K; Perola, M; Lindström, J; Swift, AJ; Uusitupa, M; Atalay, M; Lakka, TA; Rauramaa, R; Bolton, JL; Fowkes, G; Fraser, RM; Price, JF; Fischer, K; Krjutå Kov, K; Metspalu, A; Mihailov, E; Langenberg, C; Luan, J; Ong, KK; Chines, PS; Keinanen-Kiukaanniemi, SM; Saaristo, TE; Edkins, S; Franks, PW; Hallmans, G; Shungin, D; Morris, AD; Palmer, CN; Erbel, R; Moebus, S; Nöthen, MM; Pechlivanis, S; Hveem, K; Narisu, N; Hamsten, A; Humphries, SE; Strawbridge, RJ; Tremoli, E; Grallert, H; Thorand, B; Illig, T; Koenig, W; Müller-Nurasyid, M; Peters, A; Boehm, BO; Kleber, ME; März, W; Winkelmann, BR; Kuusisto, J; Laakso, M; Arveiler, D; Cesana, G; Kuulasmaa, K; Virtamo, J; Yarnell, JW; Kuh, D; Wong, A; Lind, L; de Faire, U; Gigante, B; Magnusson, PK; Pedersen, NL; Dedoussis, G; Dimitriou, M; Kolovou, G; Kanoni, S; Stirrups, K; Bonnycastle, LL; Njølstad, I; Wilsgaard, T; Ganna, A; Rehnberg, E; Hingorani, A; Kivimaki, M; Kumari, M; Assimes, TL; Barroso, I; Boehnke, M; Borecki, IB; Deloukas, P; Fox, CS; Frayling, T; Groop, LC; Haritunians, T; Hunter, D; Ingelsson, E; Kaplan, R; Mohlke, KL; O'Connell, JR; Schlessinger, D; Strachan, DP; Stefansson, K; van Duijn, CM; Abecasis, GR; McCarthy, MI; Hirschhorn, JN; Qi, L; Loos, RJ; Lindgren, CM; North, KE; Heid, IM |
| Source: |
PLoS Genetics , 9 (6) , Article e1003500. (2013) |
| Publication Year: |
2013 |
| Collection: |
University College London: UCL Discovery |
| Description: |
Given the anthropometric differences between men and women and previous evidence of sex-difference in genetic effects, we conducted a genome-wide search for sexually dimorphic associations with height, weight, body mass index, waist circumference, hip circumference, and waist-to-hip-ratio (133,723 individuals) and took forward 348 SNPs into follow-up (additional 137,052 individuals) in a total of 94 studies. Seven loci displayed significant sex-difference (FDR |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
https://discovery.ucl.ac.uk/id/eprint/1396696/1/journal.pgen.1003500.pdf; https://discovery.ucl.ac.uk/id/eprint/1396696/ |
| Availability: |
https://discovery.ucl.ac.uk/id/eprint/1396696/1/journal.pgen.1003500.pdf; https://discovery.ucl.ac.uk/id/eprint/1396696/ |
| Rights: |
open |
| Accession Number: |
edsbas.9EE7F8A3 |
| Database: |
BASE |