| Title: |
Distribution of Common and Rare Genetic Markers of Second-Line-Injectable-Drug Resistance in Mycobacterium tuberculosis Revealed by a Genome-Wide Association Study |
| Authors: |
Conkle-Gutierrez, Derek; Kim, Calvin; Ramirez-Busby, Sarah M.; Modlin, Samuel J.; Mansjö, Mikael; Werngren, Jim; Rigouts, Leen; Hoffner, Sven E.; Valafar, Faramarz |
| Contributors: |
HHS | NIH | National Institute of Allergy and Infectious Diseases |
| Source: |
Antimicrobial Agents and Chemotherapy ; volume 66, issue 6 ; ISSN 0066-4804 1098-6596 |
| Publisher Information: |
American Society for Microbiology |
| Publication Year: |
2022 |
| Description: |
Point mutations in the rrs gene and the eis promoter are known to confer resistance to the second-line injectable drugs (SLIDs) amikacin (AMK), capreomycin (CAP), and kanamycin (KAN). While mutations in these canonical genes confer the majority of SLID resistance, alternative mechanisms of resistance are not uncommon and threaten effective treatment decisions when using conventional molecular diagnostics. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1128/aac.02075-21 |
| Availability: |
https://doi.org/10.1128/aac.02075-21; https://journals.asm.org/doi/pdf/10.1128/aac.02075-21 |
| Rights: |
https://doi.org/10.1128/ASMCopyrightv2 ; https://journals.asm.org/non-commercial-tdm-license |
| Accession Number: |
edsbas.9EE9487F |
| Database: |
BASE |