| Title: |
Reducing Post-Operative Alveolo-Pleural Fistula by Applying PGA-Sheets (Neoveil) after Major Lung Resection: A Historical Case-Control Study |
| Authors: |
Sassorossi C.; Congedo M. T.; Nachira D.; Tabacco D.; Evangelista J.; Calabrese G.; Nocera A.; Margaritora S.; Lococo F. |
| Contributors: |
Sassorossi, Carolina; Congedo, Maria Teresa; Nachira, Dania; Tabacco, Diomira; Chiappetta, M.; Evangelista, Jessica; di Gioia, A.; Di Resta, V.; Sorino, C.; Mondoni, M.; Leoncini, F.; Calabrese, Giuseppe; Napolitano, A. G.; Nocera, Adriana; Lococo, A.; Margaritora, Stefano; Lococo, Filippo |
| Publisher Information: |
MDPI |
| Publication Year: |
2023 |
| Collection: |
Università Cattolica del Sacro Cuore: PubliCatt |
| Subject Terms: |
aerostasis; air-leak; lung cancer; lung resection; NSCLC; Settore MED/21 - CHIRURGIA TORACICA |
| Description: |
Alveolo-pleural fistula remains a serious post-operative complication in lung cancer patients after surgery, which is associated with prolonged hospital stay and higher healthcare costs. The aim of this study is to evaluate the efficacy of a polyglycol acid (PGA)-sheet known as Neoveil in preventing post-operative air-leak in cases of detected intra-operative air-leak after lung resection. Between 11/2021 and 7/2022, a total of 329 non-small cell lung cancer (NSCLC) patients were surgically treated in two institutions. Major lung resections were performed in 251 cases. Among them, 44 patients with significant intra-operative air-leak at surgery were treated by reinforcing staple lines with Neoveil (study group). On the other hand, a historical group (selected by propensity score matched analysis) consisting of 44 lung cancer patients with significant intra-operative air leak treated by methods other than the application of sealant patches were considered as the control group. The presence of prolonged air-leak (primary endpoint), pleural drainage duration, hospital stay, and post-operative complication rates were evaluated. The results showed that prolonged air-leak (>5 days after surgery) was not observed in study group, while this event occurred in four patients (9.1%) in the control group. Additionally, a substantial reduction (despite not statistically significant) in the chest tube removal was noted in the study group with respect to the control group (3.5 vs. 4.5, p = 0.189). In addition, a significant decrease in hospital stay (4 vs. 6 days, p = 0.045) and a reduction in post-operative complications (2 vs. 10, p = 0.015) were observed in the study group when compared with the control group. Therefore, in cases associated with intra-operative air-leak after major lung resection, Neoveil was considered a safer and more effective aerostatic tool and represents a viable option during surgical procedures. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/37048802; info:eu-repo/semantics/altIdentifier/wos/WOS:000969857100001; volume:12; issue:7; firstpage:N/A; lastpage:N/A; issueyear:2023; journal:JOURNAL OF CLINICAL MEDICINE; https://hdl.handle.net/10807/245915 |
| DOI: |
10.3390/jcm12072719 |
| Availability: |
https://hdl.handle.net/10807/245915; https://doi.org/10.3390/jcm12072719 |
| Rights: |
info:eu-repo/semantics/openAccess ; license:Creative commons ; license uri:http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.9F64C3D9 |
| Database: |
BASE |