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Co-infection and ICU-acquired infection in COIVD-19 ICU patients: a secondary analysis of the UNITE-COVID data set

Title:	Co-infection and ICU-acquired infection in COIVD-19 ICU patients: a secondary analysis of the UNITE-COVID data set
Authors:	Conway Morris, Andrew; Kohler, Katharina; De Corte, Thomas; Ercole, Ari; De Grooth, Harm-Jan; Elbers, Paul W G; Povoa, Pedro; Morais, Rui; Koulenti, Despoina; Jog, Sameer; Nielsen, Nathan; Jubb, Alasdair; Cecconi, Maurizio; De Waele, Jan; Marco Bezzi; Alicia Gira; Philipp Eller; Tarikul Hamid; Injamam Ull Haque; Wim De Buyser; Antonella Cudia; Daniel De Backer; Pierre Foulon; Vincent Collin; Jan De Waele; Jolien Van Hecke; Elisabeth De Waele; Claire Van Malderen; Jean-Baptiste Mesland; Patrick Biston; Michael Piagnerelli; Lionel Haentjens; Nicolas De Schryver; Jan Van Leemput; Philippe Vanhove; Pierre Bulpa; Viktoria Ilieva; David Katz; Alexandra Binnie; Anna Geagea; Fernando Tirapegui; Gustavo Lago; Jerónimo Graf; Rodrigo Perez-Araos; Patricio Vargas; Felipe Martinez; Eduardo Labarca; Daniel Molano Franco; Daniela Parra-Tanoux; Luis Felipe Reyes; David Yepes; Filip Periš; Sanda Stojanović Stipić; Cynthia Vanessa Campozano Burgos; Paulo Roberto Navas Boada; Jose Luis Barberan Brun; Juan Pablo Paredes Ballesteros; Gamal Abdelnasser; Ahmed Hammouda; Omar Elmandouh; Ahmed Azzam; Aliae Mohamed Hussein; Islam Galal; Ahmed K Awad; Mohammed A Azab; Maged Abdalla; Hebatallah Assal; Mostafa Alfishawy; Sherief Ghozy; Samar Tharwat; Abdullah Eldaly; Anneli Ellervee; Veronika Reinhard; Anne Chrisment; Chrystelle Poyat; Julio Badie; Fernando Berdaguer Ferrari; Björn Weiss; Clara Schellenberg; Julius J Grunow; Marco Lorenz; Stefan J Schaller; Peter Spieth; Marc Bota; Falk Fichtner; Kristina Fuest; Tobias Lahmer; Johannes Herrmann; Patrick Meybohm; Nikolaos Markou; Georgia Vasileiadou; Evangelia Chrysanthopoulou; Panagiotis Papamichalis; Ioanna Soultati; Sameer Jog; Kushal Kalvit; Sheila Nainan Myatra; Ivan Krupa; Aisa Tharwat; Alistair Nichol; Aine McCarthy; Ata Mahmoodpoor; Tommaso Tonetti; Paolo Isoni; Savino Spadaro; Carlo Alberto Volta; Lucia Mirabella; Alberto Noto; Gaetano Florio; Amedeo Guzzardella; Chiara Paleari; Federica Baccanelli; Marzia Savi; Massimo Antonelli; Gennaro De Pascale; San Luca; Barbara Vaccarini; Giorgia Montrucchio; Gabriele Sales; Katia Donadello; Leonardo Gottin; Marta Nizzero; Enrico Polati; Silvia De Rosa; Demet Sulemanji; Abdurraouf Abusalama; Muhammed Elhadi; Montelongo De FelipeJesus; Daniel Rodriguez Gonzalez; Victor Hugo Madrigal Robles; Nancy Canedo; Alejandro Esquivel Chavez; Tarek Dendane; Bart Grady; Ben de Jong; Eveline van der Heiden; Patrick Thoral; Bas van den Bogaard; Peter E Spronk; Sefanja Achterberg; Melanie Groeneveld; Ralph K L So; Calvin de Wijs; Harm Scholten; Albertus Beishuizen; Alexander D Cornet; Auke C Reidinga; Hetty Kranen; Roos Mensink; Spaarne Gasthuis; Sylvia den Boer; Marcel de Groot; Oliver Beck; Carina Bethlehem; Bas van Bussel; Tim Frenzel; Celestine de Jong; Rob Wilting; Jozef Kesecioglu; Jannet Mehagnoul-Schipper; Datonye Alasia; Ashok Kumar; Ahad Qayyum; Muhammad Rana; Mustafa Abu Jayyab; Rosario Quispe Sierra; Aaron Mark Hernandez; José de Almeida; Lúcia Taborda; Mónica Anselmo; Tiago Ramires; Catarina Silva; Carolina Roriz; Rui Morais; Pedro Póvoa; Patricia Patricio; André Pinto; Maria Lurdes Santos; Vasco Costa; Pedro Cunha; Celina Gonçalves; Sandra Nunes; João Camões; Diana Adrião; Ana Oliveira; Ali Omrani; Muna Al Maslamani; Abdurrahmaan Suei Elbuzidi; Bara Mahmoud Al Qudah; Abdel Rauof Akkari; Mohamed Alkhatteb; Anas Baiou; Ahmed Husain; Mohamed Alwraidat; Ibrahim Abdulsalam Saif; Dana Bakdach; Amna Ahmed; Mohamed Aleef; Awadh Bintaher; Cristina Petrisor; Evgeniy Popov; Ksenia Popova; Mariia Dementienko; Boris Teplykh; Alexey Pyregov; Liubov Davydova; Belskii Vladislav; Elena Neporada; Ivan Zverev; Svetlana Meshchaninova; Dmitry Sokolov; Elena Gavrilova; Irina Shlyk; Igor Poliakov; Marina Vlasova; Ohoud Aljuhani; Amina Alkhalaf; Felwa Bin Humaid; Yaseen Arabi; Ahmed Kuhail; Omar Elrabi; Madihah E Ghannam; Ng Teng Fong; Amit Kansal; Vui Kian Ho; Jensen Ng; Raquel Rodrígez García; Xiana Taboada Fraga; Ma Del Pilar García-Bonillo; Antonio Padilla-Serrano; Marta Martin Cuadrado; Carlos Ferrando; Ignacio Catalan-Monzon; Laura Galarza; Fernando Frutos-Vivar; Jorge Jimenez; Carmen Rodríguez-Solis; Enric Franquesa-Gonzalez; Guillermo Pérez Acosta; Luciano Santana Cabrera; Juan Pablo Aviles Parra; Francisco Muñoyerro Gonzalez; Maria Del Carmen Lorente Conesa; Ignacio Yago Martinez Varela; Orville Victoriano Baez Pravia; Maria Cruz Martin Delgado; Carlos Munoz de Cabo; Ana-Maria Ioan; Cesar Perez-Calvo; Arnoldo Santos; Ane Abad-Motos; Javier Ripolles-Melchor; Belén Civantos Martin; Santiago Yus Teruel; Juan Higuera Lucas; Aaron Blandino Ortiz; Raúl de Pablo Sánchez; Jesús Emilio Barrueco-Francioni; Lorena Forcelledo Espina; José M Bonell-Goytisolo; Iñigo Salaverria; Antonia Socias Mir; Emilio Rodriguez-Ruiz; Virginia Hidalgo Valverde; Patricia Jimeno Cubero; Francisca Arbol Linde; Nieves Cruza Leganes; Juan Maria Romeu; Pablo Concha; José Angel Berezo-Garcia; Virginia Fraile; Cristina Cuenca-Rubio; David Pérez-Torres; Ainhoa Serrano; Clara Martínez Valero; Andrea Ortiz Suner; Leire Larrañaga; Noemi Legaristi; Gerardo Ferrigno; Safa Khlafalla; Rosita Bihariesingh-Sanchit; Hallands Sjukhus; Frank Zoerner; Jonathan Grip; Kristina Kilsand; Johan Mårtensson; Jonas Österlind; Akademiska Sjukhuset; Magnus von Seth; Västerviks Sjukhus; Johan Berkius; Samuele Ceruti; Andrea Glotta; Seval Izdes; Işıl Özkoçak Turan; Ahmet Cosar; Burcin Halacli; Necla Dereli; Mehmet Yilmaz; Türkay Akbas; Gülseren Elay; Selin Eyüpoğlu; Yelíz Bílír; Kemal Tolga Saraçoğlu; Ebru Kaya; Ayca Sultan Sahin; Pervin Korkmaz Ekren; Tuğçe Mengi; Kezban Ozmen Suner; Yakup Tomak; Ahmet Eroglu; Asad Alsabbah; Katie Hanlon; Kevin Gervin; Sean McMahon; Samantha Hagan; Caroline V Higenbottam; Randeep Mullhi; Lottie Poulton; Tomasz Torlinski; Allen Gareth; Nick Truman; Gopal Vijayakumar; Chris Hall; Alasdair Jubb; Lenka Cagova; Nicola Jones; Sam Graham; Nicole Robin; Amanda Cowton; Adrian Donnelly; Natalia Singatullina; Melanie Kent; Carole Boulanger; Zoë Campbell; Elizabeth Potter; Natalie Duric; Tamas Szakmany; Royal Brompton; Orinta Kviatkovske; Nandor Marczin; Caroline Ellis; Rajnish Saha; Chunda Sri-Chandana; John Allan; Lana Mumelj; Harish Venkatesh; Vera Nina Gotz; Anthony Cochrane; Barbara Ficial; Shruthi Kamble; Nuttha Lumlertgul; Christopher Oddy; Susan Jain; Giulia Beatrice Crapelli; Aikaterini Vlachou; David Golden; Sweyn Garrioch; Jeremy Henning; Gupta Loveleena; Miriam Davey; Lina Grauslyte; Erika Salciute-Simene; Martin Cook; Danny Barling; Phil Broadhurst; Sarah Purvis; Michael Spivey; Benjamin Shuker; Irina Grecu; Daniel Harding; James T Dean; Nathan D Nielsen; Sama Al-Bayati; Mohammed Al-Sadawi; Mariane Charron; Peter Stubenrauch; Jairo Santanilla; Catherine Wentowski; Dorothea Rosenberger; Polikseni Eksarko; Randeep Jawa
Contributors:	Andrew, Conway Morri; Katharina, Kohler; Thomas, De Corte; Ari, Ercole; Harm-Jan, De Grooth; Paul W G, Elber; Pedro, Povoa; Rui, Morai; Despoina, Koulenti; Sameer, Jog; Nathan, Nielsen; Alasdair, Jubb; Maurizio, Cecconi; Jan, De Waele; Bezzi, Marco; Gira, Alicia; Eller, Philipp; Hamid, Tarikul; Ull Haque, Injamam; De Buyser, Wim; Cudia, Antonella; De Backer, Daniel; Foulon, Pierre; Collin, Vincent; De Waele, Jan; Van Hecke, Jolien; De Waele, Elisabeth; Van Malderen, Claire; Mesland, Jean-Baptiste; Biston, Patrick; Piagnerelli, Michael; Haentjens, Lionel; De Schryver, Nicola; Van Leemput, Jan; Vanhove, Philippe; Bulpa, Pierre; Ilieva, Viktoria; Katz, David; Binnie, Alexandra; Geagea, Anna; Tirapegui, Fernando; Lago, Gustavo; Graf, Jerónimo; Perez-Araos, Rodrigo; Vargas, Patricio; Martinez, Felipe; Labarca, Eduardo; Molano Franco, Daniel; Parra-Tanoux, Daniela; Felipe Reyes, Lui; Yepes, David; Periš, Filip; Stojanović Stipić, Sanda; Vanessa Campozano Burgos, Cynthia; Roberto Navas Boada, Paulo; Luis Barberan Brun, Jose; Pablo Paredes Ballesteros, Juan; Abdelnasser, Gamal; Hammouda, Ahmed; Elmandouh, Omar; Azzam, Ahmed; Mohamed Hussein, Aliae; Galal, Islam; K Awad, Ahmed; A Azab, Mohammed; Abdalla, Maged; Assal, Hebatallah; Alfishawy, Mostafa; Ghozy, Sherief; Tharwat, Samar; Eldaly, Abdullah; Ellervee, Anneli; Reinhard, Veronika; Chrisment, Anne; Poyat, Chrystelle; Badie, Julio; Berdaguer Ferrari, Fernando; Weiss, Björn; Schellenberg, Clara; J Grunow, Juliu; Lorenz, Marco; J Schaller, Stefan; Spieth, Peter; Bota, Marc; Fichtner, Falk; Fuest, Kristina; Lahmer, Tobia; Herrmann, Johanne; Meybohm, Patrick; Markou, Nikolao; Vasileiadou, Georgia; Chrysanthopoulou, Evangelia; Papamichalis, Panagioti; Soultati, Ioanna; Jog, Sameer; Kalvit, Kushal; Nainan Myatra, Sheila; Krupa, Ivan; Tharwat, Aisa; Nichol, Alistair
Publication Year:	2022
Collection:	Università degli Studi di Trento: CINECA IRIS
Description:	Background: The COVID-19 pandemic presented major challenges for critical care facilities worldwide. Infections which develop alongside or subsequent to viral pneumonitis are a challenge under sporadic and pandemic conditions; however, data have suggested that patterns of these differ between COVID-19 and other viral pneumonitides. This secondary analysis aimed to explore patterns of co-infection and intensive care unit-acquired infections (ICU-AI) and the relationship to use of corticosteroids in a large, international cohort of critically ill COVID-19 patients. Methods: This is a multicenter, international, observational study, including adult patients with PCR-confirmed COVID-19 diagnosis admitted to ICUs at the peak of wave one of COVID-19 (February 15th to May 15th, 2020). Data collected included investigator-assessed co-infection at ICU admission, infection acquired in ICU, infection with multi-drug resistant organisms (MDRO) and antibiotic use. Frequencies were compared by Pearson's Chi-squared and continuous variables by Mann-Whitney U test. Propensity score matching for variables associated with ICU-acquired infection was undertaken using R library MatchIT using the "full" matching method. Results: Data were available from 4994 patients. Bacterial co-infection at admission was detected in 716 patients (14%), whilst 85% of patients received antibiotics at that stage. ICU-AI developed in 2715 (54%). The most common ICU-AI was bacterial pneumonia (44% of infections), whilst 9% of patients developed fungal pneumonia; 25% of infections involved MDRO. Patients developing infections in ICU had greater antimicrobial exposure than those without such infections. Incident density (ICU-AI per 1000 ICU days) was in considerable excess of reports from pre-pandemic surveillance. Corticosteroid use was heterogenous between ICUs. In univariate analysis, 58% of patients receiving corticosteroids and 43% of those not receiving steroids developed ICU-AI. Adjusting for potential confounders in the propensity-matched cohort, ...
Document Type:	article in journal/newspaper
Language:	English
Relation:	info:eu-repo/semantics/altIdentifier/pmid/35922860; info:eu-repo/semantics/altIdentifier/wos/WOS:000835683700002; volume:26; issue:1; firstpage:23601; lastpage:23613; numberofpages:13; journal:CRITICAL CARE; https://hdl.handle.net/11572/364508
DOI:	10.1186/s13054-022-04108-8
DOI:	10.1186/s13054-022-04108-8#citeas
Availability:	https://hdl.handle.net/11572/364508; https://doi.org/10.1186/s13054-022-04108-8; https://ccforum.biomedcentral.com/articles/10.1186/s13054-022-04108-8#citeas
Rights:	info:eu-repo/semantics/openAccess ; license:Creative commons ; license uri:http://creativecommons.org/licenses/by/4.0/
Accession Number:	edsbas.9F896E9F
Database:	BASE