| Title: |
Nitric Oxide–Dependent Vasodilation in Young Spontaneously Hypertensive Rats |
| Authors: |
Radaelli, Alberto; Mircoli, Luca; Mori, Ileana; Mancia, Giuseppe; Ferrari, Alberto U. |
| Source: |
Hypertension ; volume 32, issue 4, page 735-739 ; ISSN 0194-911X 1524-4563 |
| Publisher Information: |
Ovid Technologies (Wolters Kluwer Health) |
| Publication Year: |
1998 |
| Description: |
—Conflicting evidence exists on the possible impairment of tonic nitric oxide (NO)–mediated vasodilation as a causative factor in the genesis of human as well as experimental hypertension. We evaluated the tonic NO-dependent vasodilation from the pressor response to NO synthesis inhibition by N G -monomethyl- l -arginine (L-NMMA) in 9 conscious, chronically instrumented spontaneously hypertensive rats (SHR) at 12 weeks of age, ie, during the early established hypertensive stage. Nine age-matched Wistar-Kyoto rats (WKY) were used as controls. The pressor responses to L-NMMA (100 mg · kg −1 IV bolus plus 1.5 mg · kg −1 · min −1 infusion for 60 minutes) as well as to non–NO-dependent pressor stimuli, namely, vasopressin (2, 4, and 8 ng · kg −1 ) and phenylephrine (0.5, 1, and 2 μg · kg −1 ) given as IV boluses, were assessed both under control conditions and during suppression of autonomic reflexes by hexamethonium (30 mg · kg −1 IV bolus+1.5 mg · kg −1 · min −1 infusion). Rather than being reduced, the pressor responses to L-NMMA were 39% and 71% larger in the control and areflexic conditions, respectively, than those observed in WKY (both P |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1161/01.hyp.32.4.735 |
| DOI: |
10.1161/01.HYP.32.4.735 |
| Availability: |
https://doi.org/10.1161/01.hyp.32.4.735; https://www.ahajournals.org/doi/full/10.1161/01.HYP.32.4.735 |
| Accession Number: |
edsbas.9FCDBC1F |
| Database: |
BASE |