| Title: |
Cofilin activation in peripheral CD4 T cells of HIV-1 infected patients: a pilot study |
| Authors: |
Wu, Yuntao; Yoder, Alyson; Yu, Dongyang; Wang, Weifeng; Liu, Juan; Barrett, Tracey; Wheeler, David; Schlauch, Karen |
| Publisher Information: |
BioMed Central Ltd. |
| Publication Year: |
2008 |
| Collection: |
BioMed Central |
| Description: |
Cofilin is an actin-depolymerizing factor that regulates actin dynamics critical for T cell migration and T cell activation. In unstimulated resting CD4 T cells, cofilin exists largely as a phosphorylated inactive form. Previously, we demonstrated that during HIV-1 infection of resting CD4 T cells, the viral envelope-CXCR4 signaling activates cofilin to overcome the static cortical actin restriction. In this pilot study, we have extended this in vitro observation and examined cofilin phosphorylation in resting CD4 T cells purified from the peripheral blood of HIV-1-infected patients. Here, we report that the resting T cells from infected patients carry significantly higher levels of active cofilin, suggesting that these resting cells have been primed in vivo in cofilin activity to facilitate HIV-1 infection. HIV-1-mediated aberrant activation of cofilin may also lead to abnormalities in T cell migration and activation that could contribute to viral pathogenesis. |
| Document Type: |
report |
| Language: |
English |
| Relation: |
http://www.retrovirology.com/content/5/1/95 |
| Availability: |
http://www.retrovirology.com/content/5/1/95 |
| Rights: |
Copyright 2008 Wu et al; licensee BioMed Central Ltd. |
| Accession Number: |
edsbas.9FD09697 |
| Database: |
BASE |