| Title: |
HLA-B*15:01-positive severe COVID-19 patients lack CD8+ T cell pools with highly expanded public clonotypes |
| Authors: |
Rowntree, Louise C; Allen, Lilith F; Hagen, Ruth R; McQuilten, Hayley A; Quadeer, Ahmed A; Chaurasia, Priyanka; Kaewpreedee, Prathanporn; Lee, Kelly W K; Cohen, Carolyn A; Petersen, Jan; Littler, Dene R; Habel, Jennifer R; Zhang, Wuji; Cheng, Samuel M S; Chan, Ken Ka Pang; Kwok, Janette S Y; Leung, Kathy S M; Wu, Joseph T; Lee, Cheuk-Kwong; Davies, Jane; Pannaraj, Pia S; Kaity Allen, E; Thomas, Paul G; Tosif, Shidan; Crawford, Nigel W; Lappas, Martha; Thevarajan, Irani; Lewin, Sharon R; Kent, Stephen J; Juno, Jennifer A; Bond, Katherine A; Williamson, Deborah A; Holmes, Natasha E; Smibert, Olivia C; Gordon, Claire L; Trubiano, Jason A; Kotsimbos, Tom C; Cheng, Allen C; Efstathiou, Claudia; Turtle, Lance; Thwaites, Ryan S; Brightling, Christopher E; PHOSP-COVID Collaborative Group; Rossjohn, Jamie; McKay, Matthew R; Tian, Jinmin; Liu, William Jun; Gao, George Fu; Xu, Jianqing; Sonehara, Kyuto; Ishii, Ken J; Namkoong, Ho; Okada, Yukinori; Peiris, Malik; Hui, David S. C.; Poon, Leo L. M.; Doherty, Peter C.; Nguyen, Thi H. O.; Valkenberg, Sophie A.; Kedzierska, Katherine |
| Contributors: |
University of St Andrews.School of Medicine; University of St Andrews.Infection and Global Health Division |
| Publication Year: |
2025 |
| Collection: |
University of St Andrews: Digital Research Repository |
| Subject Terms: |
HLA-B*15:01; COVID-19; T cell receptors; Middle aged; Aged; CD8+ T cells; CD8-positive T-lymphocytes - immunology; Severe disease; Male; SARS-CoV-2 - immunology; Adult; Humans; Female; COVID-19 - immunology - genetics; Spike glycoprotein; Coronavirus - immunology; DAS; MCC |
| Description: |
Funding: This research was funded in whole or part by the National Health and Medical Research Council (NHMRC). This work was supported by NHMRC L1 to K.K. (#1173871), NHMRC EL1 to L.C.R. (#2026357) and T.H.O.N. (#1194036), NHMRC EL2 to D.A.W. (#1174555), J.A.J. (#2009308), and S.A.V. (#2007929). NHMRC Early Career Fellowships to C.L.G. (#1160963) and J.A.T. (#1139902). S.J.K. is supported by a NHMRC Senior Principal Research Fellowship (#1136322). J.R. is supported by a NHMRC Investigator Award. J.A.J. is funded by the Charles and Sylvia Viertel Charitable Foundation. W.Z. and J.R.H. are supported by the Melbourne Research Scholarship from University of Melbourne. This work was supported by Theme-based Research Scheme of the Research Grants Council of the Hong Kong Special Administrative Region (HKSAR), China (#T11-712/19-N) to K.K., Theme-based Research Scheme of the Research Grants Council of HKSAR (#T11-705/21-N) to A.A.Q., M.R.M., M.P., L.L.M.P., and S.A.V., Health and Medical Research Fund (#1903003) to D.S.C.H., Medical Research Future Fund (MRFF) Award (#1202445) to K.K., MRFF Award (#2005544) to S.J.K., J.A.J., D.A.W., A.C.C., and K.K., MRFF Award (#2016062) to L.C.R., S.J.K., J.A.J., J.A.T., J.R., T.H.O.N., and K.K., NHMRC Program Grant (#1149990) to S.J.K., Australian Research Council (ARC) Discovery Project (#DP230102850) to A.A.Q. and M.R.M., and NIH contract CIVC-HRP (HHS-NIH-NIAID-BAA2018) to P.G.T. and K.K. This work was supported by the National Institute of Allergy and Infectious Diseases UO1 grant 1U01AI144616-01 “Dissection of Influenza Vaccination and Infection for Childhood Immunity” to P.S.P., P.G.T., and K.K. K.S.M.L. and J.T.W. were supported by Health and Medical Research Fund (#21200122, COVID190126 and CID-HKU2) and AIR@InnoHK administered by Innovation and Technology Commission of The Government of the HKSAR. M.P. and L.L.M.P. were supported by InnoHK, an initiative of the Innovation and Technology Commission, the Government of the HKSAR. S.T. is supported by a Murdoch Children’s ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
Proceedings of the National Academy of Sciences of the United States of America; 328238919; 105015033027; Jisc: 3283177; https://hdl.handle.net/10023/33120; https://www.scopus.com/pages/publications/105015033027 |
| DOI: |
10.1073/pnas.2503145122 |
| Availability: |
https://hdl.handle.net/10023/33120; https://doi.org/10.1073/pnas.2503145122; https://www.scopus.com/pages/publications/105015033027 |
| Rights: |
Copyright © 2025 the Author(s). Published by PNAS. This open access article is distributed under Creative Commons Attribution License 4.0 (CC BY). |
| Accession Number: |
edsbas.A003B4A |
| Database: |
BASE |