Genetically determined body mass index is associated with diffuse large B-cell lymphoma in polygenic and Mendelian randomization analyses
| Title: | Genetically determined body mass index is associated with diffuse large B-cell lymphoma in polygenic and Mendelian randomization analyses |
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| Authors: | Moore, Amy; Kane, Eleanor; Teras, Lauren R; Machiela, Mitchell J; Arias, Joshua; Panagiotou, Orestis A; Monnereau, Alain; Doo, Nicole Wong; Wang, Zhaoming; Slager, Susan L; Vermeulen, Roel C H; Vajdic, Claire M; Smedby, Karin E; Spinelli, John J; Vijai, Joseph; Giles, Graham G; Link, Brian K; Arslan, Alan A; Nieters, Alexandra; Bracci, Paige M; Camp, Nicola J; Salles, Gilles; Cozen, Wendy; Hjalgrim, Henrik; De Vivo, Immaculata; Adami, Hans-Olov; Albanes, Demetrius; Becker, Nikolaus; Benavente, Yolanda; Bisanzi, Simonetta; Boffetta, Paolo; Brennan, Paul; Brooks-Wilson, Angela R; Canzian, Federico; Clavel, Jacqueline; Conde, Lucia; Cox, David G; Curtin, Karen; Foretova, Lenka; Ghesquières, Hervé; Glimelius, Bengt; Habermann, Thomas M; Hofmann, Jonathan N; Lan, Qing; Liebow, Mark; Lincoln, Anne; Maynadie, Marc; McKay, James; Melbye, Mads; Miligi, Lucia; Milne, Roger L; Molina, Thierry J; Morton, Lindsay M; North, Kari E; Offit, Kenneth; Padoan, Marina; Piro, Sara; Patel, Alpa V; Purdue, Mark P; Ravichandran, Vignesh; Riboli, Elio; Severson, Richard K; Southey, Melissa C; Staines, Anthony; Tinker, Lesley F; Travis, Ruth C; Wang, Sophia S; Weiderpass, Elisabete; Weinstein, Stephanie; Zheng, Tongzhang; Chanock, Stephen J; Rothman, Nathaniel; Birmann, Brenda M; Cerhan, James R; Berndt, Sonja I |
| Contributors: | Moore, Amy; Kane, Eleanor; Teras, Lauren R; Machiela, Mitchell J; Arias, Joshua; Panagiotou, Orestis A; Monnereau, Alain; Doo, Nicole Wong; Wang, Zhaoming; Slager, Susan L; Vermeulen, Roel C H; Vajdic, Claire M; Smedby, Karin E; Spinelli, John J; Vijai, Joseph; Giles, Graham G; Link, Brian K; Arslan, Alan A; Nieters, Alexandra; Bracci, Paige M; Camp, Nicola J; Salles, Gille; Cozen, Wendy; Hjalgrim, Henrik; De Vivo, Immaculata; Adami, Hans-Olov; Albanes, Demetriu; Becker, Nikolau; Benavente, Yolanda; Bisanzi, Simonetta; Boffetta, Paolo; Brennan, Paul; Brooks-Wilson, Angela R; Canzian, Federico; Clavel, Jacqueline; Conde, Lucia; Cox, David G; Curtin, Karen; Foretova, Lenka; Ghesquières, Hervé; Glimelius, Bengt; Habermann, Thomas M; Hofmann, Jonathan N; Lan, Qing; Liebow, Mark; Lincoln, Anne; Maynadie, Marc; Mckay, Jame; Melbye, Mad; Miligi, Lucia; Milne, Roger L; Molina, Thierry J; Morton, Lindsay M; North, Kari E; Offit, Kenneth; Padoan, Marina; Piro, Sara; Patel, Alpa V; Purdue, Mark P; Ravichandran, Vignesh; Riboli, Elio; Severson, Richard K; Southey, Melissa C; Staines, Anthony; Tinker, Lesley F; Travis, Ruth C; Wang, Sophia S; Weiderpass, Elisabete; Weinstein, Stephanie; Zheng, Tongzhang; Chanock, Stephen J; Rothman, Nathaniel; Birmann, Brenda M; Cerhan, James R; Berndt, Sonja I |
| Publication Year: | 2026 |
| Collection: | IRIS Università degli Studi di Bologna (CRIS - Current Research Information System) |
| Subject Terms: | Adiposity / genetics Body Mass Index* Case-Control Studies Female Genetic Predisposition to Disease Genome-Wide Association Study Humans Leukemia; Lymphocytic; Chronic; B-Cell / genetics Lymphoma; Follicular / genetics Lymphoma; Large B-Cell; Diffuse* / epidemiology Lymphoma; Diffuse* / genetics Male Mendelian Randomization Analysis Middle Aged Multifactorial Inheritance* Obesity* / complications Obesity* / genetics Polymorphism; Single Nucleotide Risk Factors Waist-Hip Ratio |
| Description: | Obesity has been associated with non-Hodgkin lymphoma (NHL), but the evidence is inconclusive. We examined the association between genetically determined adiposity and four common NHL subtypes: diffuse large B-cell lymphoma (DLBCL), follicular lymphoma, chronic lymphocytic leukemia, and marginal zone lymphoma, using eight genome-wide association studies of European ancestry (N = 10,629 cases, 9505 controls) and constructing polygenic scores for body mass index (BMI), waist-to-hip ratio (WHR), and waist-to-hip ratio adjusted for BMI (WHRadjBMI). Higher genetically determined BMI was associated with an increased risk of DLBCL [odds ratio (OR) per standard deviation (SD) = 1.18, 95% confidence interval (95% CI): 1.05–1.33, p =.005]. This finding was consistent with Mendelian randomization analyses, which demonstrated a similar increased risk of DLBCL with higher genetically determined BMI (ORper SD = 1.12, 95% CI: 1.02–1.23, p =.03). No significant associations were observed with other NHL subtypes. Our study demonstrates a positive link between a genetically determined BMI and an increased risk of DLBCL, providing additional support for increased adiposity as a risk factor for DLBCL. |
| Document Type: | article in journal/newspaper |
| File Description: | ELETTRONICO |
| Language: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/40910475; info:eu-repo/semantics/altIdentifier/wos/WOS:001564404900001; volume:158; issue:1; firstpage:45; lastpage:59; numberofpages:15; journal:INTERNATIONAL JOURNAL OF CANCER; https://hdl.handle.net/11585/1046160 |
| DOI: | 10.1002/ijc.70039 |
| Availability: | https://hdl.handle.net/11585/1046160; https://doi.org/10.1002/ijc.70039; https://onlinelibrary.wiley.com/doi/10.1002/ijc.70039 |
| Rights: | info:eu-repo/semantics/openAccess ; license:Licenza per Accesso Aperto. Creative Commons Attribuzione (CCBY) ; license uri:iris.PUB15 |
| Accession Number: | edsbas.A020857 |
| Database: | BASE |