Molecular classification to refine surgical and radiotherapeutic decision-making in meningioma
| Title: | Molecular classification to refine surgical and radiotherapeutic decision-making in meningioma |
|---|---|
| Authors: | Wang, JZ; Patil, V; Landry, AP; Gui, C; Ajisebutu, A; Liu, J; Saarela, O; Pugh, SL; Won, M; Patel, Z; Yakubov, R; Kaloti, R; Wilson, C; Cohen-Gadol, A; Zaazoue, MA; Tabatabai, G; Tatagiba, M; Behling, F; Almiron Bonnin, DA; Holland, EC; Kruser, TJ; Barnholtz-Sloan, JS; Sloan, AE; Horbinski, C; Chotai, S; Chambless, LB; Gao, A; Rebchuk, AD; Makarenko, S; Yip, S; Sahm, F; Maas, SLN; Tsang, DS; Dincer, A; Moliterno, J; Passlack, P; Schittenhelm, J; la Fougère, C; Santacroce, A; Renovanz, M; Zada, G; Hnenny, L; Zherebitskiy, V; Malta, TM; Butowski, NA; Perry, A; Raleigh, DR; Morokoff, A; Drummond, KJ; Pathmanaban, ON; Fountain, DM; Islim, AI; Mawrin, C; Jenkinson, MD; Short, SC; Deng, M; von Deimling, A; Jungwirth, G; Jungk, C; Herold-Mende, C; Ricklefs, FL; Lamszus, K; Westphal, M; Mathiesen, TI; Timmer, M; Galldiks, N; Goldbrunner, R; Au, K; Schmidt, NO; Fountas, KN; Tzannis, A; Everson, RG; Boutros, PC; Ng, HK; Javadpour, M; Hanemann, CO; Dunn, IF; Sulman, EP; Kurz, SC; Snuderl, M; Youngblood, M; Horbinski, CM; Cimino, PJ; Vogelbaum, MA; Raghunathan, A; Galanis, E; Giannini, C; Lachance, DH; Kaufmann, TJ; Ehret, F; Tonn, JC; Schichor, C; Pollo, B; Saladino, A; Dimeco, F; Snyder, JM; Noushmehr, H; Castro, AV |
| Publisher Information: | Springer Science and Business Media LLC |
| Publication Year: | 2024 |
| Collection: | The University of Liverpool Repository |
| Description: | Treatment of the tumor and dural margin with surgery and sometimes radiation are cornerstones of therapy for meningioma. Molecular classifications have provided insights into the biology of disease; however, response to treatment remains heterogeneous. In this study, we used retrospective data on 2,824 meningiomas, including molecular data on 1,686 tumors and 100 prospective meningiomas, from the RTOG-0539 phase 2 trial to define molecular biomarkers of treatment response. Using propensity score matching, we found that gross tumor resection was associated with longer progression-free survival (PFS) across all molecular groups and longer overall survival in proliferative meningiomas. Dural margin treatment (Simpson grade 1/2) prolonged PFS compared to no treatment (Simpson grade 3). Molecular group classification predicted response to radiotherapy, including in the RTOG-0539 cohort. We subsequently developed a molecular model to predict response to radiotherapy that discriminates outcome better than standard-of-care classification. This study highlights the potential for molecular profiling to refine surgical and radiotherapy decision-making. |
| Document Type: | article in journal/newspaper |
| Language: | English |
| ISSN: | 1078-8956 |
| Relation: | Collapse authors list. Wang, JZ, Patil, V, Landry, AP, Gui, C, Ajisebutu, A, Liu, J, Saarela, O, Pugh, SL, Won, M, Patel, Z et al (show 88 more authors) , Yakubov, R, Kaloti, R, Wilson, C, Cohen-Gadol, A, Zaazoue, MA, Tabatabai, G, Tatagiba, M, Behling, F, Almiron Bonnin, DA, Holland, EC orcid:0000-0002-3792-7120 , Kruser, TJ, Barnholtz-Sloan, JS orcid:0000-0001-6190-9304 , Sloan, AE, Horbinski, C orcid:0000-0001-8340-9992 , Chotai, S orcid:0000-0001-5981-3231 , Chambless, LB, Gao, A, Rebchuk, AD orcid:0000-0001-5553-346X , Makarenko, S, Yip, S, Sahm, F orcid:0000-0001-5441-1962 , Maas, SLN, Tsang, DS orcid:0000-0002-9762-6901 , Dincer, A, Moliterno, J, Passlack, P, Schittenhelm, J, la Fougère, C, Santacroce, A, Renovanz, M, Zada, G, Hnenny, L, Zherebitskiy, V, Malta, TM, Butowski, NA, Perry, A, Raleigh, DR, Morokoff, A, Drummond, KJ, Pathmanaban, ON, Fountain, DM, Islim, AI, Mawrin, C, Jenkinson, MD orcid:0000-0003-4587-2139 , Short, SC, Deng, M, von Deimling, A, Jungwirth, G, Jungk, C, Herold-Mende, C, Ricklefs, FL, Lamszus, K, Westphal, M, Mathiesen, TI, Timmer, M, Galldiks, N, Goldbrunner, R, Au, K, Schmidt, NO, Fountas, KN, Tzannis, A, Everson, RG, Boutros, PC, Ng, HK, Javadpour, M, Hanemann, CO, Dunn, IF, Sulman, EP, Kurz, SC, Snuderl, M, Youngblood, M, Horbinski, CM, Cimino, PJ, Vogelbaum, MA, Raghunathan, A, Galanis, E, Giannini, C, Lachance, DH, Kaufmann, TJ, Ehret, F, Tonn, JC, Schichor, C, Pollo, B, Saladino, A, Dimeco, F, Snyder, JM, Noushmehr, H and Castro, AV (2024) Molecular classification to refine surgical and radiotherapeutic decision-making in meningioma Nature Medicine, 30 (11). pp. 3173-3183. ISSN 1078-8956, 1546-170X |
| DOI: | 10.1038/s41591-024-03167-4 |
| Availability: | https://livrepository.liverpool.ac.uk/3189154/; https://doi.org/10.1038/s41591-024-03167-4 |
| Accession Number: | edsbas.A0443DFE |
| Database: | BASE |