| Title: |
Wound healing: Natural history and risk factors for delay in Australian patients treated with antibiotics for Mycobacterium ulcerans disease |
| Authors: |
O’Brien, DP; Friedman, ND; McDonald, A; Callan, P; Hughes, A; Walton, A; Athan, E |
| Contributors: |
Pluschke, G |
| Publisher Information: |
PUBLIC LIBRARY SCIENCE |
| Publication Year: |
2018 |
| Collection: |
The University of Melbourne: Digital Repository |
| Description: |
BACKGROUND: Healing times following treatment with antibiotics, and factors that influence healing, have not been reported in Australian patients with Mycobacterium ulcerans. METHODOLOGY/PRINCIPAL FINDINGS: Healing times were determined for all M. ulcerans cases treated by a single physician with antibiotics at Barwon Health, Victoria, from 1/1/13-31/12/16. Lesions were categorised by induration size: category A ≤ 400mm2, Category B 401-1600mm2 and Category C ≥1601mm2. A logistic regression analysis was performed to determine risk factors for prolonged wound healing (>150 days from antibiotic commencement). 163 patients were included; 92 (56.4%) were male and median age was 58 years (IQR 39-73 years). Baseline lesion size [available in 145 (89.0%) patients] was categorised as A in 46 (31.7%), B in 67 (46.2%) and C in 32 (22.1%) patients. Fifty (30.7%) patients had surgery. In those treated with antibiotics alone, 83.0% experienced a reduction in induration size after 2 weeks, then 70.9% experienced an increase in induration size from the lowest point, and 71.7% experienced an increase in ulceration size. A linear relationship existed between the time induration resolved and wound healing began. Median time to heal was 91 days (IQR 70-148 days) for category A lesions; significantly shorter than for category B lesions (128 days, IQR 91-181 days, p = 0.05) and category C lesions (169 days, IQR 159-214 days, p |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISSN: |
1935-2727 |
| Relation: |
O’Brien, D. P., Friedman, N. D., McDonald, A., Callan, P., Hughes, A., Walton, A. & Athan, E. (2018). Wound healing: Natural history and risk factors for delay in Australian patients treated with antibiotics for Mycobacterium ulcerans disease. Plos Neglected Tropical Diseases, 12 (3), https://doi.org/10.1371/journal.pntd.0006357.; https://hdl.handle.net/11343/253441 |
| Availability: |
https://hdl.handle.net/11343/253441 |
| Rights: |
https://creativecommons.org/licenses/by/4.0 ; CC BY |
| Accession Number: |
edsbas.A0577A99 |
| Database: |
BASE |