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Clinical characteristics, risk factors and outcomes in patients with severe COVID-19 registered in the International Severe Acute Respiratory and Emerging Infection Consortium WHO clinical characterisation protocol: a prospective, multinational, multicentre, observational study

Title:	Clinical characteristics, risk factors and outcomes in patients with severe COVID-19 registered in the International Severe Acute Respiratory and Emerging Infection Consortium WHO clinical characterisation protocol: a prospective, multinational, multicentre, observational study
Authors:	Felipe Reyes, Luis; Murthy, Srinivas; Garcia-Gallo, Esteban; Irvine, Mike; Merson, Laura; Martin-Loeches, Ignacio; Rello, Jordi; Taccone, Fabio S.; Fowler, Robert A.; Docherty, Annemarie B.; Kartsonaki, Christiana; Aragao, Irene; Barrett, Peter W.; Beane, Abigail; Burrell, Aidan; Cheng, Matthew Pellan; Christian, Michael D.; Cidade, Jose Pedro; Citarella, Barbara Wanjiru; Donnelly, Christl A.; Fernandes, Susana M.; French, Craig; Haniffa, Rashan; Harrison, Ewen M.; Ho, Antonia Ying Wai; Joseph, Mark; Khan, Irfan; Kho, Michelle E.; Kildal, Anders Benjamin; Kutsogiannis, Demetrios; Lamontagne, Francois; Lee, Todd C.; Li Bassi, Gianluigi; Lopez Revilla, Jose Wagner; Marquis, Catherine; Millar, Jonathan; Neto, Raul; Nichol, Alistair; Parke, Rachael; Pereira, Rui; Poli, Sergio; Povoa, Pedro; Ramanathan, Kollengode; Rewa, Oleksa; Riera, Jordi; Shrapnel, Sally; Silva, Maria Joao; Udy, Andrew; Uyeki, Timothy; Webb, Steve A.; Wils, Evert-Jan; Rojek, Amanda; Olliaro; Piero L.; Abdukahil; Sheryl Ann; Abe, Ryuzo; Abel, Laurent; Absil, Lara; Acharya, Subhash; Acker, Andrew; Adachi, Shingo; Adam, Elisabeth; Adrião, Diana; Ageel, Saleh Al; Ain, Quratul; Ainscough, Kate; Ait Hssain, Ali; Ait Tamlihat, Younes; Akimoto, Takako; Akmal, Ernita; Al Qasim, Eman; Alalqam, Razi; Alam, Tanvir; Al-dabbous, Tala; Alegre, Cynthia; Alex, Beatrice; Alexandre, Kévin; Al-Fares, Abdulrahman; Alfoudri, Huda; Ali Shah, Naseem; Alidjnou, Kazali Enagnon; Aliudin, Jeffrey; Allavena, Clotilde; Alves, João Melo; Alves, João; Alves, Rita; Amaral, Maria; Ampaw, Phoebe; Andini, Roberto; Andrejak, Claire; Angheben, Andrea; Angoulvant, François; Ansart, Séverine; Antonelli, Massimo; Antunes de Brito, Carlos Alexandre; Apriyana, Ardiyan; Arabi, Yaseen; Arancibia, Francisco; Arcadipane, Antonio; Archambault, Patrick; Arenz, Lukas; Arlet , Jean-Benoît; ArnoldDay, Christel; Arora, Lovkesh; Arora, Rakesh; Artaud-Macari, Elise; Aryal, Diptesh; Asensio, Angel; Assie, Jean Baptiste; Atique, Anika; Attanyake, AM Udara Lakshan; Auchabie, Johann; Aumaitre, Hugues; Azemar, Laurène; Azoulay, Cecile; Bach, Benjamin; Bachelet, Delphine; Badr, Claudine; Baillie, J. Kenneth; Bak, Erica; Bakakos, Agamemnon; Bal, Andriy; Bani-Sadr, Firouzé; Barrasa, Helena; Barbalho, Renata; Barclay, Wendy S.; Barnikel, Michaela; Barrigoto, Cleide; Bartoli, Marie; Bartone, Cheryl; Baruch, Joaquín; Basmaci, Romain; Bauer, Jules; Bautista, Diego; Behilill, Sylvie; Beljantsev, Aleksandr; Bellemare, David; Beltrame, Anna; Beluze, Marine; Benech, Nicolas; Benkerrou, Dehbia; Bennett, Suzanne; Bento, Luís; Berdal, Jan-Erik; Bergeaud, Delphine; Bertolino, Lorenzo; Bessis, Simon; Bevilcaqua, Sybille; Bhatt, Amar; Bhavsar, Krishna; Bianchi, Isabella; Bianco, Claudia; Bikram Singh, Moirangthem; Bin Humaid, Felwa; Biston, Patrick; Bitker, Laurent; Blanco-Schweizer, Pablo; Blandino Ortiz, Aaron; Blier, Catherine; Blot, Mathieu; Boccia, Filomena; Bodenes, Laetitia; Bogaert, Debby; Bolze, Pierre-Adrien; Bompart, François; Borges, Diogo; Borie, Raphaël; Bosse, Hans Martin; Botelho-Nevers, Elisabeth; Bouadma, Lila; Bouchaud, Olivier; Bouchez, Sabelline; Bouhmani, Dounia; Bouhour, Damien; Bouiller, Kévin; Bouillet, Laurence; Bouisse, Camile; Boureau, Anne-Sophie; Bouscambert, Maude; Bouziotis, Jason; Boxma, Bianca; Boyer-Besseyre, Marielle; Boylan, Maria; Bozza, Fernando Augusto; Brack, Matthew; Braga, Cynthia; Brandenburger, Timo; Brás Monteiro, Filipa; Brazzi, Luca; Breen, Dorothy; Breen, Patrick; Brickell, Kathy; Broadley, Tessa; Browne, Alex; Brozzi, Nicolas; Buchtele, Nina; Buesaquillo, Christian; Buisson, Marielle; Burhan, Erlina; Bustos, Ingrid G.; Cabie, André; Cabral, Susana; Caceres, Eder; Cadoz, Cyril; Calligy, Kate; Calvache, Jose Andres; Camões, João; Campana, Valentine; Campbell, Paul; Canepa, Cecilia; Cantero, Mireia; Caraux-Paz, Pauline; Cárcel, Sheila; Cardellino, Chiara; Cardoso, Filipa; Cardoso, Filipe; Cardoso, Nelson; Cardoso, Sofia; Carelli, Simone; Carlier, Nicolas; Carney, Gayle; Carpenter, Chloe; Carret, Marie-Christine; Carrier, François Martin; Carson, Gail; Casanova, Maire-Laure; Cascão, Mariana; Casimiro, José; Cassandra, Bailey; Castañeda, Silvia; Castanheira, Nidyanara; Castor-Alexandre, Guylaine; Castrillón, Henry; Castro, Ivo; Catarino, Ana; Catherine, François-Xavier; Cavalin, Roberta; Cavayas, Alexandros; Ceccato, Adrian; Cervantes-Gonzalez, Minerva; Chair, Anissa; Chakveatze, Catherine; Chan, Adrienne; Chand, Meera; Chantalat Auger, Christelle; Chapplain, Jean-Marc; Chaudary, Mobin; Chen, Anjellica; Chen, Yih-Sharng; Cheret, Antoine; Chiarabini, Thibault; Chica, Julian; Chirouze, Catherine; Chiumello, Davide; Cho, Hwa Jin; Cho, Sung Min; Cholley, Bernard; Chopin, Marie-Charlotte; Ciullo, Anna; Clarke, Jennifer; Clohisey, Sara; Coca, Necsoi; Codan, Cassidy; Cody, Caitriona; Coelho, Alexandra; Colin, Gwenhaël; Collins, Michael; Colombo, Sebastiano Maria; Combs, Pamela; Connor, Marie; Conrad, Anne; Contreras, Sofía; Cooke, Graham S.; Copland, Mary; Cordel, Hugues; Corley, Amanda; Cormican, Sarah; Cornelis, Sabine; Corpuz, Arianne Joy; Corvaisier, Grégory; Couffignal, Camille; Couffin-Cadiergues, Sandrine; Courtois, Roxane; Cousse, Stéphanie; Croonen, Sabine; Crowl, Gloria; Crump, Jonathan; Cruz, Claudina; Csete, Marc; Cullen, Caroline; Cummings, Matthew; Curley, Gerard; Curlier, Elodie; Custodio, Paula; da Silva Filipe, Ana; Da Silveira, Charlene; Dabaliz, AlAwwab; Dagens, Andrew; Dalton, Heidi; Dalton, Jo; Daneman, Nick; Dankwa,Emmanuelle; Dantas, Jorge; D'Aragon, Frédérick; de Mendoza, Diego; De Montmollin, Etienne; de Oliveira França, Rafael Freitas; De Pablo, Raúl; de Pinho Oliveira, Ana Isabel; De Rosa, Rosanna; de Silva, Thushan; De vries, Peter; Deacon, Jillian; Dean, David; Debard, Alexa; Debray, Marie-Pierre; DeCastro, Nathalie; Dechert, William; Deconninck, Lauren; Decours, Romain; Delacroix, Isabelle; Delfos, Nathalie M.; Deligiannis, Ionna; Dell'Amore, Andrea; Delmas, Christelle; Delobel, Pierre; Denis, Emmanuelle; Deplanque, Dominique; Depuydt, Pieter; Desai, Mehul; Descamps, Diane; Desvallée, Mathilde; Dewayanti, Santi; Diallo, Alpha; Diamantis, Sylvain; Diaz, Rodrigo; Diaz, Juan Jose; Diaz, Priscila; Didier, Kévin; Diehl, Jean-Luc; Dieperink, Wim; Dimet, Jérôme; Dinot, Vincent; Diop, Fara; Diouf, Alphonsine; Dishon, Yael; Djossou, Félix; Dondorp, Arjen M; Donnelly, Maria; Donohue, Chloe; Dorival, Céline; D'Ortenzio, Eric; Douglas, James Joshua; Douma, Renee; Dournon, Nathalie; Downer, Triona; Downing, Mark; Drake, Tom; Driscoll, Aoife; Duarte Fonseca, Claudio; Dubos, François; Duculan, Toni; Dudman, Susanne; Dunning, Jake; Duplaix, Mathilde; Durante-Mangoni, Emanuele; Durham III, Lucian; Duthoit, Juliette; Duval, Xavier; Dyrhol-Riise, Anne Margarita; Echeverria-Villalobos, Marco; Egan, Siobhan; Eira, Carla; El Sanharawi, Mohammed; Elapavaluru, Subbarao; Elharrar, Brigitte; Ellerbroek, Jacobien; Ellis, Rachael; Eloy, Philippine; Elshazly, Tarek; Enderle, Isabelle; Engelmann, Ilka; Enouf, Vincent; Epaulard, Olivier; Escher, Martina; Esperatti, Mariano; Esperou, Hélène; Esposito-Farese, Marina; Estevão, João; Etienne, Manuel; Ettalhaoui, Nadia; Evers, Mirjam; Fabre, Isabelle; Faheem, Amna; Fahy, Arabella; Fairfield, Cameron J.; Faria, Pedro; Farooq, Ahmed; Farshait, Nataly; Fatoni, Arie Zainul; Faure, Karine; Favory, Raphaël; Fayed, Mohamed; Feely, Niamh; Fernandes, Jorge; Fernandes, Marília; Fernandes, Susana; Ferrand Devouge, Eglantine; Ferrão, Joana; Ferraz, Mário; Ferrer- Roca, Ricard; Ferriere, Nicolas; Figueiredo-Mello, Claudia; Fiorda, Juan; Flament, Thomas; Flateau, Clara; Fletcher, Tom; Florio, Letizia Lucia; Flynn, Brigid; Foley, Claire; Fonseca, Tatiana; Fontela, Patricia; Forsyth, Simon; Foster, Denise; Foti, Giuseppe; Fourn, Erwan; Franch-Llasat, Diego; Fraser, Christophe; Fraser, John; Freire, Marcela Vieira; Freitas Ribeiro, Ana; Friedrich, Caren; Fritz, Ricardo; Fry, Stéphanie; Fuentes, Nora; Fukuda, Masahiro; Gaborieau, Valérie; Gaci, Rostane; Gagliardi, Massimo; Gagneux-Brunon, Amandine; Gaião, Sérgio; Gail Skeie, Linda; Gallagher, Phil; Gamble, Carrol; Garan, Arthur; Garcia, Rebekha; Garot, Denis; Garrait, Valérie; Gault, Nathalie; Gavin, Aisling; Gaymard, Alexandre; Gebauer, Johannes; Gerbaud Morlaes, Louis; Germano, Nuno; Ghosn, Jade; Giani, Marco; Gibson, Jess; Gigante, Tristan; Gilg, Morgane; Giordano, Guillermo; Girvan, Michelle; Gissot, Valérie; Giwangkancana, Gezy; Gnall, Eric; Goco, Geraldine; Goehringer, François; Goepel, Siri; Goffard, Jean-Christophe; Golob, Jonathan; Gómez- Junyent, Joan; Gonzalez Gonzalez, Alicia; Gorenne, Isabelle; Goubert, Laure; Goujard, Cécile; Goulenok, Tiphaine; Grable, Margarite; Graf, Jeronimo; Grandin, Edward Wilson; Grasselli, Giacomo; Grazioli, Lorenzo; Green, Christopher A.; Greenhalf, William; Grieco, Domenico Luca; Griffee, Matthew; Griffiths, Fiona; Grigoras, Ioana; Groenendijk, Albert; Gruner, Heidi; Gu, Yusing; Guedj, Jérémie; Guellec, Dewi; Guerguerian, Anne-Marie; Guerreiro, Daniela; Guery, Romain; Guillaumot, Anne; Guilleminault, Laurent; Guimard, Thomas; Haber, Daniel; Hadri, Nadir; Hakak, Sheeba; Hall, Matthew; Hall, Adam; Halpin, Sophie; Hamer, Ansley; Hamidfar, Rebecca; Hammond, Terese; Hardwick, Hayley; Harrison, Janet; Hayat, Muhammad; Hays, Leanne; Heerman, Jan; Heggelund, Lars; Hendry, Ross; Hennessy, Martina; Henriquez- 5 Trujillo, Aquiles; Hentzien, Maxime; Herekar, Fivzia; Hernandez-Montfort, Jaime; Hershey, Andrew; Hesstvedt, Liv; Hidayah, Astarini; Higgins, Eibhilin; Higgins, Dawn; Hinton, Samuel; Hipólito-Reis, Ana; Hiraiwa, Hiroaki; Hoctin, Alexandre; Hoffmann, Isabelle; Hoiting, Oscar; Holt, Rebecca; Holter, Jan Cato; Horby, Peter; Horcajada, Juan Pablo; Hoshino, Koji; Houas, Ikram; Hough, Catherine L.; Hsu, Jimmy Ming-Yang; Hulot, Jean-Sébastien; Ijaz, Samreen; Illes, Hajnal-Gabriela; Imbert, Patrick; Inácio, Hugo; Isgett, Sarah; Ishani, Palliya Guruge Pramodya Ishani; Isidoro, Tiago; Isnard, Margaux; Itai, Junji; Ivulich, Daniel; Jaafar, Danielle; Jaafoura, Salma; Jackson, Clare; Jacquet, Pierre; Jamieson, Nina; Jaureguiberry, Stéphane; Jawad, Issrah; Jayakumar, Devachandran; Jego, Florence; Jenum, Synne; Jimbo-Sotomayor, Ruth; Jorge García, Ruth Noemí; Joseph, Cédric; Joshi, Swosti; Jourdain, Mercé; Jouvet, Philippe; Jung, Hanna; Juzar, Dafsah; Kafif, Ouifiya; Kaguelidou, Florentia; Kali, Sabina; Kalomoiri, Smaragdi; Kambiya, Paul; Kandamby, Darshana Hewa; Kandel, Chris; Kant, Ravi; Kasugai, Daisuke; Kataria, Anant; Katz, Kevin; Kaur Johal, Simreen; Kay, Christy; Keating, Sean; Kelly, Andrea; Kelly, Sadie; Kennedy, Ryan; Kennon, Kalynn; Kerroumi, Younes; Kestelyn, Evelyne; Khalid, Imrana; Khalil, Antoine; Khan, Coralie; Khanal, Sushil; Kho, Michelle E; Khoo, Saye; Khoso, Nasir; Kida, Yuri; Kiiza, Peter; Kim, Jae Burm; Kimmoun, Antoine; Kindgen- Milles, Detlef; Kitamura, Nobuya; Klenerman, Paul; Kloumann Bekken, Gry; Knight, Stephen; Kodippily, Chamira; Kohns Vasconcelos, Malte; Koirala, Sabin; Komatsu, Mamoru; Kosgei, Caroline; Kpangon, Arsène; Krawczyk, Karolina; Kumar, Ashok; Kumar, Deepali; Kumar, Mukesh; Kumar Vecham, Pavan; Kurtzman, Ethan; Kusumastuti, Neurinda Permata; Kyriakoulis, Konstantinos; Lachatre, Marie; Laffey, John G; Laine, Fabrice; Lambert, Marc; Lamontagne, François; Langelot-Richard, Marie; Langlois, Vincent; Lantang, Eka Yudha; Lanza, Marina; Laouénan, Cédric; Laribi, Samira; Lariviere, Delphine; Launay, Odile; Law, Andrew; Lawrence, Cassie; Le, Minh; Le Bris, Cyril; Le Falher, Georges; Le Fevre, Lucie; Le Hingrat, Quentin; Le Maréchal, Marion; Le Mestre, Soizic; Le Nagard, Hervé; Le Turnier, Paul; Lee, Su Hwan; Lee, James; Leeming, Gary; Lefebvre, Bénédicte; Lefevre, Benjamin; LeGac, Sylvie; Lelievre, Jean-Daniel; Lellouche, François; Lemaignen, Adrien; Lemee, Véronique; Lemeur, Anthony; Lemmink, Gretchen; León, Rafael; Leone, Michela; Lepiller, Quentin; Lescure, François-Xavier; Lesens, Olivier; Lesouhaitier, Mathieu; Levy, Bruno; Levy, Yves; Levy- Marchal, Claire; L'Her, Erwan; Liang, Janet; Liaquat, Ali; Liegeon, Geoffrey; Lim, Wei Shen; Lima, Chantre; Lina, Bruno; Lind, Andreas; Lingas, Guillaume; Link, Linda; Lion-Daolio, Sylvie; Lissauer, Samantha; Liu, Keibun; Livrozet, Marine; Lolong, Navy; Lopes, Diogo; Lopez-Colon, Dalia; Loschner, Anthony L.; Loufti, Bouchra; Louis, Guillame; Lourenco, Silvia; Lucet, Jean Christophe; Luna, Carlos M.; Lungu, Olguta; Luong, Liem; Luton, Dominique; Lwin, Nilar; Lyons, Ruth; Maasikas, Olavi; Mabiala, Oryane; Macheda, Gabriel; Macias Sanchez, Juan; Madhok, Jai; Madiha, Hashmi; Mahy, Sophie; Maia, Raquel; Maier, Lars Siegfried; Maillet, Mylène; Maitre, Thomas; Malfertheiner, Maximilian; Malik, Nadia; Malvy, Denis; Manda, Victoria; Mandei, Jose M.; Mandelbrot, Laurent; Mankikian, Julie; Manning, Edmund; Manuel, Aldric; Maria Sant`Ana Malaque, Ceila; Marino, Daniel; Marino, Flávio; Mariz, Carolline de Araújo; Markowicz, Samuel; Marques, Ana; Marsh, Brian; Marsh, Laura; Marshall, John; Martelli, Celina Turchi; Martin, Emily; Martin-Blondel, Guillaume; Martinelli, Alessandra; Martins, Ana; Martins, João; Martins, Nuno; Martins Rego, Caroline; Martucci, Gennaro; Marwali, Eva Miranda; Maslove, 6 David; Mason, Sabina; Mat Nor, Basri; Mathieu, Daniel; Mattei, Mathieu; Matulevics, Romans; May, Jennifer; Maynar, Javier; Mazzoni, Thierry; Mc Evoy, Natalie; McCarthy, Aine; McCarthy, Anne; McCloskey, Colin; McConnochie, Rachael; McDermott, Sherry; McDonald, Sarah; McElwee, Samuel; McGeer, Allison; McKay, Chris; McKeown, Johnny; McLean, Kenneth A.; McNicholas, Bairbre; Meaney, Edel; Mear-Passard, Cécile; Mechlin, Maggie; Mele, Ferruccio; Melo, Luis; Mendes, Joao Joao; Menkiti, Ogechukwu; Menon, Kusum; Mentré, France; Mentzer, Alexander J.; Mercier, Emmanuelle; Mercier, Noémie; Mergeay-Fabre, Mayka; Mergler, Blake; Mesquita, António; Meybeck, Agnès; Meyer, Dan; Meynert, Alison M.; Meysonnier, Vanina; Meziane, Amina; Mezidi, Mehdi; Michelet, Isabelle; Mihelis, Efstathia; Mihnovitš, Vladislav; Miranda-Maldonado, Hugo; Moin, Asma; Molina, David; Molinos, Elena; Mone, Mary; Monteiro, Agostinho; Montes, Claudia; Montrucchio, Giorgia; Moore, Sarah; Moore, Shona C.; Morales Cely, Lina; Moro, Lucia; Morton, Ben; Motherway, Catherine; Motos, Ana; Mouquet, Hugo; Mouton Perrot, Clara; Moyet, Julien; Mullaert, Jimmy; Müller, Fredrik; Müller, Karl Erik; Muneeb, Syed; Murris, Marlène; Myrodia, Dimitra Melia; Nagpal, Dave; Nagrebetsky, Alex; Narasimhan, Mangala; Nasim Khan, Rashid; Neant, Nadège; Neb, Holger; Neumann, Emily; Ng, Wing Yiu; Ng, Pauline Yeung; Nguyen, Duc; Ni Choileain, Orna; Nonas, Stephanie; Noret, Marion; Norman, Lisa; Notari, Alessandra; Noursadeghi, Mahdad; Nseir, Saad; Nunez, Jose I; Nurnaningsih, Nurnaningsih; Occhipinti, Giovanna; O'Donnell, Max; Ogston, Tawnya; Ogura, Takayuki; Oh, Tak-Hyuk; O'Hearn, Katie; Ohshimo, Shinichiro; Oinam, Budhacharan Singh; Oliveira, João; Oliveira, Larissa; Olliaro, Piero L.; O'Neil, Conar; Ong, David S. Y.; Oosthuyzen, Wilna; Opavsky, Anne; Openshaw, Peter; Orakzai, Saijad; Orozco-Chamorro, Claudia Milena; Ortoleva, Jamel; Osatnik, Javier; Ouamara, Nadia; Ouissa, Rachida; Owyang, Clark; Oziol, Eric; Pabasara, H M Upulee; Pagadoy, Maïder; Pages, Justine; Palacios, Mario; Palacios, Amanda; Palmarini, Massimo; Panarello, Giovanna; Panda, Prasan Kumar; Paneru, Hem; Panigada, Mauro; Papadopoulos, Aurélie; Parker, Melissa; Parra, Briseida; Pasquier, Jérémie; Patauner, Fabian; Patel, Junaid; Patrão, Luís; Patricio, Patricia; Patrier, Juliette; Patterson, Lisa; Paul, Christelle; Paul, Mical; Paulos, Jorge; Paxton, William A.; Payen, Jean-François; Peek, Giles; Peelman, Florent; Peiffer-Smadja, Nathan; Peigne, Vincent; Pejkovska, Mare; Peltan, Ithan D.; Perez, Daniel; Periel, Luis; Perpoint, Thomas; Pesenti, Antonio; Pestre, Vincent; Petroušová, Lenka; Petrov-Sanchez, Ventzislava; Pettersen, Frank Olav; Peytavin, Gilles; Pharand, Scott; Piagnerelli, Michael; Picard, Walter; Picone, Olivier; Pierobon, Carola; Pimentel, Carlos; Piroth, Lionel; Pius, Riinu; Piva, Simone; Plantier, Laurent; Plotkin, Daniel; Poissy, Julien; Pokeerbux, Ryadh; Pollakis, Georgios; Ponscarme, Diane; Post, Andra-Maris; Postma, Douwe F.; Póvoas, Diana; Powis, Jeff; Prapa, Sofia; Preau, Sébastien; Prebensen, Christian; Preiser, Jean-Charles; Prinssen, Anton; Pritchard, Mark; Priyadarshani, Gamage Dona Dilanthi; Proença, Lúcia; Puéchal, Oriane; Pulicken, Matthew; Purcell, Gregory; Quesada, Luisa; Quinones-Cardona, Vilmaris; Quist-Paulsen, Else; Quraishi, Mohammed; Rabaud, Christian; Rafael, Aldo; Rafiq, Marie; Rahutullah, Arsalan; Rainieri, Fernando; Ralib, Azrina; Ramakrishnan, Nagarajan; Ramos, Grazielle Viana; Rana, Asim; Rashan, Aasiyah; Rashan, Thalha; Rasmin, Menaldi; Rätsep, Indrek; Real, Andre; Rebaudet, Stanislas; Reeve, Brenda; Rehan, Ali; Rehman, Attaur; Reid, Liadain; Reikvam, Dag Henrik; Reis, Renato; Remppis, Jonathan; Remy, Martine; Ren, Hongru; Renk, Hanna; Resende, Liliana; Revest, Matthieu; Reyes, Luis F.; Reyes, Tiago; 7 Ribeiro, Maria Ines; Richardson, David; Richardson, Denise; Richier, Laurent; Rios, Ana Lúcia; Rishu, Asgar; Rizer, Nicholas; Roberto, André; Roberts, Stephanie; Robertson, David L.; Robineau, Olivier; Roche-Campo, Ferran; Rodari, Paola; Rodeia, Simão; Roger, Pierre-Marie; Romaru, Juliette; Roncon-Albuquerque Jr, Roberto; Rosa-Calatrava, Manuel; Rose, Michael; Rosenberger, Dorothea; Rossanese, Andrea; Rossetti, Matteo; Rossignol, Bénédicte; Rossignol, Patrick; Rössler, Bernhard; Rousset, Stella; Roy, Carine; Roze, Benoît; Rusmawatiningtyas, Desy; Russell, Clark D.; Ryckaert, Steffi; Rygh Holten, Aleksander; Saba, Isabela; Sadaf, Sairah; Sadat, Musharaf; Sahraei, Valla; Saint-Gilles, Maximilien; Salahuddin, Nawal; Salazar, Leonardo; Sales, Gabriele; Sallaberry, Stéphane; Salmon Gandonniere, Charlotte; Salvator, Hélène; Sanchez, Olivier; Sanchez-Miralles, Angel; Sancho-Shimizu, Vanessa; Sandhu, Gyan; Sandrine, Pierre-François; Sandulescu, Oana; Santos, Marlene; Sarfo-Mensah, Shirley; Sarmiento, Iam Claire E.; Sarton, Benjamine; Satyapriya, Sree; Saviciute, Egle; Schaffer, Justin; Schermer, Tjard; Scherpereel, Arnaud; Schneider, Marion; Schroll, Stephan; Schwameis, Michael; Scott, Janet T.; Scott-Brown, James; Sedillot, Nicholas; Seitz, Tamara; Semaille, Caroline; Semple, Malcolm G.; Senneville, Eric; Sepulveda, Claudia; Sequeira, Filipa; Sequeira, Tânia; Serpa Neto, Ary; Shadowitz, Ellen; Shamsah, Mohammad; Sharma, Pratima; Shaw, Catherine A.; Shaw, Victoria; Sheharyar, Ashraf; Shi, Haixia; Shiekh, Mohiuddin; Shime, Nobuaki; Shimizu, Hiroaki; Shimizu, Keiki; Shimizu, Naoki; Shum, Hoi Ping; Si Mohammed, Nassima; Sibiude, Jeanne; Siddiqui, Atif; Sigfrid, Louise; Sillaots, Piret; Silva, Catarina; Silva, Rogério; Sin, Wai Ching; Skogen, Vegard; Smith, Sue; Smood, Benjamin; Smyth, Michelle; Snacken, Morgane; So, Dominic; Solis, Monserrat; Solomon, Joshua; Solomon, Tom; Somers, Emily; Sommet, Agnès; Song, Myung Jin; Song, Rima; Song, Tae; Sonntagbauer, Michael; Soum, Edouard; Sousa, Ana Chora; Sousa, Marta; Sousa Uva, Maria; Souza-Dantas, Vicente; Sperry, Alexandra; Sri Darshana, B. P. Sanka Ruwan; Sriskandan, Shiranee; Stabler, Sarah; Staudinger, Thomas; Stecher, Stephanie-Susanne; Stienstra, Ymkje; Stiksrud, Birgitte; Streinu-Cercel, Anca; Streinu-Cercel, Adrian; Strudwick, Samantha; Stuart, Ami; Stuart, David; Suen, Jacky Y.; Suen, Gabriel; Sultana, Asfia; Summers, Charlotte; Surovcová, Magdalena; Syrigos, Konstantinos; Sztajnbok, Jaques; Szuldrzynski, Konstanty; Tabrizi, Shirin; Taccone, Fabio; Tagherset, Lysa; Taleb, Sara; Talsma, Jelmer; Tan, Le Van; Tanaka, Hiroyuki; Tanaka, Taku; Taniguchi, Hayato; Tanveer, Hussain; Tardivon, Coralie; Tattevin, Pierre; Taufik, M Azhari; Tedder, Richard S.; Teixeira, João; Tejada, Sofia; Tellier, Marie-Capucine; Teotonio, Vanessa; Téoulé, François; Terpstra, Pleun; Terrier, Olivier; Terzi, Nicolas; Tessier-Grenier, Hubert; Thibault, Vincent; Thill, Benoît; Thompson MD; Shaun; Thomson, Emma C.; Thomson, David; Thuy, Duong Bich; Thwaites, Ryan S.; Timsit, Jean-François; Tirupakuzhi Vijayaraghavan, Bharath Kumar; Tissot, Noémie; Toki, Maria; Tolppa, Timo; Tonby, Kristian; Torres, Antoni; Torres-Zevallos, Hernando; Trapani, Tony; Treoux, Théo; Trieu, Huynh Trung; Tromeur, Cécile; Trontzas, Ioannis; Troost, Jonathan; Trouillon, Tiffany; Truong, Jeanne; Tual, Christelle; Tubiana, Sarah; Tuite, Helen; Turmel, Jean-Marie; Turtle, Lance C. W.; Twardowski, Pawel; Uchiyama, Makoto; Udayanga, PG Ishara; Ullrich, Roman; Uribe, Alberto; Usman, Asad; Val-Flores, Luís; Valran, Amélie; Van De Velde, Stijn; van den Berge, Marcel; Van der Feltz, Machteld; Van Der Vekens, Nicky; Van der Voort, Peter; Van Der Werf, Sylvie; van Gulik, Laura; Van Hattem, Jarne; van Lelyveld, Steven; van Netten, Carolien; van Twillert, G; Vanel, Noémie; Vanoverschelde, oHenk; Vauchy, Charline; Veislinger, Aurélie; Ventura, Sara; Verbon, 8 Annelies; Vidal, José Ernesto; Vieira, César; Villanueva, Joy Ann; Villar, Judit; Villeneuve, Pierre-Marc; Villoldo, Andrea; Vinh Chau, Nguyen Van; Visseaux, Benoit; Visser, Hannah; Vitiello, Chiara; Vuotto, Fanny; Wang, Chih-Hsien; Wei, Jia; Weil, Katharina; Wesselius, Sanne; Wham, Murray; Whelan, Bryan; White, Nicole; Wicky, Paul Henri; Wiedemann, Aurélie; Wille, Keith; Williams, Virginie; Wolf, Timo; Xynogalas, Ioannis; Yacoub, Sophie; Yamazaki, Masaki; Yazdanpanah, Yazdan; Yelnik, Cécile; Yerkovich, Stephanie; Yokoyama, Toshiki; Yonis, Hodane; Yuliarto, Saptadi; Zaaqoq, Akram; Zabbe, Marion; Zacharowski, Kai; Zahran, Maram; Zambon, Maria; Zambrano, Miguel; Zanella, Alberto; Zoufaly, Alexander; Zucman, David.
Contributors:	L. Felipe Reye; S. Murthy; E. Garcia-Gallo; M. Irvine; L. Merson; I. Martin-Loeche; J. Rello; F.S. Taccone; R.A. Fowler; A.B. Docherty; C. Kartsonaki; I. Aragao; P.W. Barrett; A. Beane; A. Burrell; M.P. Cheng; M.D. Christian; J.P. Cidade; B.W. Citarella; C.A. Donnelly; S.M. Fernande; C. French; R. Haniffa; E.M. Harrison; A.Y.W. Ho; M. Joseph; I. Khan; M.E. Kho; A.B. Kildal; D. Kutsogianni; F. Lamontagne; T.C. Lee; G. Li Bassi; J.W. Lopez Revilla; C. Marqui; J. Millar; R. Neto; A. Nichol; R. Parke; R. Pereira; S. Poli; P. Povoa; K. Ramanathan; O. Rewa; J. Riera; S. Shrapnel; M.J. Silva; A. Udy; T. Uyeki; S.A. Webb; E. Wil; A. Rojek; Olliaro; L. Piero; Abdukahil; A. Sheryl; R. Abe; L. Abel; L. Absil; S. Acharya; A. Acker; S. Adachi; E. Adam; D. Adrião; S.A. Ageel; Q. Ain; K. Ainscough; A. Ait Hssain; Y. Ait Tamlihat; T. Akimoto; E. Akmal; E. Al Qasim; R. Alalqam; T. Alam; T. Al-dabbou; C. Alegre; B. Alex; K. Alexandre; A. Al-Fare; H. Alfoudri; N. Ali Shah; K.E. Alidjnou; J. Aliudin; C. Allavena; J.M. Alve; J. Alve; R. Alve; M. Amaral; P. Ampaw; R. Andini; C. Andrejak; A. Angheben; F. Angoulvant; S. Ansart; M. Antonelli; C.A. Antunes De Brito; A. Apriyana; Y. Arabi; F. Arancibia
Publisher Information:	ERS Publications
Publication Year:	2022
Collection:	The University of Milan: Archivio Istituzionale della Ricerca (AIR)
Subject Terms:	Settore MEDS-23/A - Anestesiologia
Description:	Due to the large number of patients with severe coronavirus disease 2019 (COVID-19), many were treated outside the traditional walls of the intensive care unit (ICU), and in many cases, by personnel who were not trained in critical care. The clinical characteristics and the relative impact of caring for severe COVID-19 patients outside the ICU is unknown. This was a multinational, multicentre, prospective cohort study embedded in the International Severe Acute Respiratory and Emerging Infection Consortium World Health Organization COVID-19 platform. Severe COVID-19 patients were identified as those admitted to an ICU and/or those treated with one of the following treatments: invasive or noninvasive mechanical ventilation, high-flow nasal cannula, inotropes or vasopressors. A logistic generalised additive model was used to compare clinical outcomes among patients admitted or not to the ICU. A total of 40 440 patients from 43 countries and six continents were included in this analysis. Severe COVID-19 patients were frequently male (62.9%), older adults (median (interquartile range (IQR), 67 (55–78) years), and with at least one comorbidity (63.2%). The overall median (IQR) length of hospital stay was 10 (5–19) days and was longer in patients admitted to an ICU than in those who were cared for outside the ICU (12 (6–23) days versus 8 (4–15) days, p
Document Type:	article in journal/newspaper
Language:	English
Relation:	info:eu-repo/semantics/altIdentifier/wos/WOS:000783165900040; volume:8; issue:1; firstpage:1; lastpage:18; numberofpages:18; journal:ERJ OPEN RESEARCH; https://hdl.handle.net/2434/1190615
DOI:	10.1183/23120541.00552-2021
Availability:	https://hdl.handle.net/2434/1190615; https://doi.org/10.1183/23120541.00552-2021
Rights:	info:eu-repo/semantics/openAccess ; license:Creative commons ; license uri:http://creativecommons.org/licenses/by-nc/4.0/
Accession Number:	edsbas.A0BA538F
Database:	BASE