| Title: |
Age-Dependent Variations in Kawasaki Disease Incidence in Japan |
| Authors: |
DeHaan, Laurel L; Copeland, Charles D; Burney, Jennifer A; Nakamura, Yosikazu; Yashiro, Mayumi; Shimizu, Chisato; Miyata, Koichi; Burns, Jane C; Cayan, Daniel R |
| Source: |
JAMA Network Open, vol 7, iss 2 |
| Publisher Information: |
eScholarship, University of California |
| Publication Year: |
2024 |
| Collection: |
University of California: eScholarship |
| Subject Terms: |
32 Biomedical and Clinical Sciences (for-2020); 3202 Clinical Sciences (for-2020); Pediatric (rcdc); Clinical Research (rcdc); 2.4 Surveillance and distribution (hrcs-rac); Adolescent (mesh); Female (mesh); Infant (mesh); Male (mesh); Humans (mesh); Child (mesh); Young Adult (mesh); Adult (mesh); Incidence (mesh); Japan (mesh); Cross-Sectional Studies (mesh); Mucocutaneous Lymph Node Syndrome (mesh); Morbidity (mesh); 42 Health sciences (for-2020) |
| Description: |
Importance: The etiology of Kawasaki disease (KD) remains elusive, with immunologic and epidemiologic data suggesting different triggers in individuals who are genetically susceptible. KD remains the most common cause of acquired heart disease in pediatric patients, and Japan is the country of highest incidence, with an increasing number of cases. Objective: To investigate whether an analysis of the epidemiologic KD record in Japan stratified by age and prefecture (subregion) may yield new clues regarding mechanisms of exposure to etiologic agents associated with KD. Design, Setting, and Participants: This cross-sectional study was conducted using a dataset of patients with KD with detailed information on location and age at onset created through nationwide surveys of hospitals caring for pediatric patients with KD throughout Japan. Pediatric patients hospitalized in Japan for KD from 1970 to 2020 were included. Data were analyzed from January 2022 to January 2024. Exposure: Pediatric patients with KD. Main Outcomes and Measures: The KD dataset was analyzed by patient age (infants [aged |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
qt24g0r0kw; https://escholarship.org/uc/item/24g0r0kw; https://escholarship.org/content/qt24g0r0kw/qt24g0r0kw.pdf |
| DOI: |
10.1001/jamanetworkopen.2023.55001 |
| Availability: |
https://escholarship.org/uc/item/24g0r0kw; https://escholarship.org/content/qt24g0r0kw/qt24g0r0kw.pdf; https://doi.org/10.1001/jamanetworkopen.2023.55001 |
| Rights: |
public |
| Accession Number: |
edsbas.A0D7EFB2 |
| Database: |
BASE |