| Title: |
The Dynamics of Adaptation to Stress from Standing Genetic Variation and de novo Mutations |
| Authors: |
Ament-Velasquez, Sandra Lorena; Gilchrist, Ciaran; Rego, Alexandre; Bendixsen, Devin P.; Brice, Claire; Grosse-Sommer, Julie Michelle; Rafati, Nima; Stelkens, Rike |
| Publisher Information: |
Uppsala universitet, Institutionen för medicinsk biokemi och mikrobiologi; Uppsala universitet, Science for Life Laboratory, SciLifeLab; Stockholm Univ, Dept Zool, Div Populat Genet, Svante Arrheniusvag 18 B, S-10691 Stockholm, Sweden.; Maastricht Univ, Fac Sci & Engn, Paul Henri Spaaklaan 1, NL-6229 EN Maastricht, Netherlands. |
| Publication Year: |
2022 |
| Collection: |
Uppsala University: Publications (DiVA) |
| Subject Terms: |
microbial experimental evolution; yeast; adaptation dynamics; environmental stress; parallelism; time series; Pool-Seq; Genetics and Genomics; Genetik och genomik; Evolutionary Biology; Evolutionsbiologi |
| Description: |
Adaptation from standing genetic variation is an important process underlying evolution in natural populations, but we rarely get the opportunity to observe the dynamics of fitness and genomic changes in real time. Here, we used experimental evolution and Pool-Seq to track the phenotypic and genomic changes of genetically diverse asexual populations of the yeast Saccharomyces cerevisiae in four environments with different fitness costs. We found that populations rapidly and in parallel increased in fitness in stressful environments. In contrast, allele frequencies showed a range of trajectories, with some populations fixing all their ancestral variation in |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
Molecular biology and evolution, 0737-4038, 2022, 39:11; PMID 36334099; ISI:000892254900003 |
| DOI: |
10.1093/molbev/msac242 |
| Availability: |
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-494643; https://doi.org/10.1093/molbev/msac242 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.A0F534BF |
| Database: |
BASE |