| Title: |
Polygenic Risk Score and Lung Adenocarcinoma Risk Among Never-Smokers by EGFR Mutation Status: A Brief Report |
| Authors: |
Blechter, B; Hsiung, CA; Wang, X; Zhang, H; Seow, WJ; Shi, J; Chatterjee, N; Kim, HN; Wong, MP; Hong, YC; Wong, JYY; Dai, J; Hosgood, HD; Wang, Z; Chang, IS; Choi, J; Wang, J; Song, M; Hu, W; Zheng, W; Kim, JH; Zhou, B; Albanes, D; Shin, MH; Chung, LP; An, SJ; Zheng, H; Yatabe, Y; Zhang, XC; Kim, YT; Shu, XO; Kim, YC; Vermeulen, RCH; Bassig, BA; Chang, J; Man, Ho JC; Ji, BT; Kubo, M; Daigo, Y; Momozawa, Y; Kamatani, Y; Honda, T; Kunitoh, H; Watanabe, SI; Miyagi, Y; Nakayama, H; Matsumoto, S; Tsuboi, M; Goto, K; Yin, Z; Takahashi, A; Goto, A; Minamiya, Y; Shimizu, K; Tanaka, K; Wu, T; Wei, F; Su, J; Kim, YH; Oh, IJ; Fun, Lee VH; Su, WC; Chen, YM; Chang, GC; Chen, KY; Huang, MS; Lin, HC; Seow, A; Park, JY; Kweon, SS; Chen, CJ; Gao, YT; Wu, C; Qian, B; Lu, D; Liu, J; Jeon, HS; Hsiao, CF; Sung, JS; Tsai, YH; Jung, YJ; Guo, H; Hu, Z; Chen, TY; Burdett, L; Yeager, M; Hutchinson, A; Berndt, SI; Wu, W; Choi, JE; Park, KH; Sung, SW; Liu, L; Kang, CH; Chen, CH; Xu, J; Guan, P; Tan, W; Wang, CL; Loon, Sihoe AD; Chen, Y; Choi, YY; Kim, JS; Yoon, HI; Cai, Q; Park, IK; Xu, P; He, Q; Chen, CY; Wu, J; Lim, WY; Chen, KC; Chan, JKC; Li, J; Chen, H; Yu, CJ; Jin, L; Fraumeni, JF; Landi, MT; Yamaji, T; Yang, Y; Hicks, B; Wyatt, K; Li, SA; Ma, H; Song, B; Cheng, S; Li, X; Ren, Y; Iwasaki, M; Zhu, J; Jiang, G; Fei, K; Wu, G; Chien, LH; Tsai, FY; Yu, J; Stevens, VL; Yang, PC; Lin, D; Chen, K; Wu, YL; Matsuo, K; Rothman, N; Shiraishi, K; Shen, H; Chanock, SJ; Kohno, T; Lan, Q |
| Publisher Information: |
Elsevier |
| Publication Year: |
2025 |
| Collection: |
University of Hong Kong: HKU Scholars Hub |
| Description: |
We assessed the association between a genome-wide polygenic risk score (PRS) developed for lung adenocarcinoma (LUAD) risk and mutation on the EGFR gene in 998 East Asian never-smoking female LUAD cases (518 EGFR-positive; 480 EGFR-negative) and 4544 never-smoking controls using case-case and multinomial regression analyses. We found that the PRS was more strongly associated with EGFR-positive LUAD compared with EGFR-negative LUAD, where the association between the fourth quartile of the PRS and EGFR-positive LUAD (odds ratio = 8.63, 95% confidence interval: 5.67-13.14) was significantly higher than the association between the fourth quartile of the PRS with EGFR-negative LUAD (odds ratio = 3.50, 95% confidence interval: 2.44-5.00) (p-heterogeneity = 3.66 × 10 -3 ). Our findings suggest that germline genetic susceptibility may be differentially associated with LUAD in never-smoking female East Asian patients depending on the cancer's mutation status, which may have important public health and clinical implications. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
Journal of Thoracic Oncology; 530; WOS:001498280800001; 521; https://hub.hku.hk/handle/10722/355739; 20 |
| DOI: |
10.1016/j.jtho.2024.11.019 |
| Availability: |
https://hub.hku.hk/handle/10722/355739; https://doi.org/10.1016/j.jtho.2024.11.019 |
| Rights: |
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. |
| Accession Number: |
edsbas.A0F63D65 |
| Database: |
BASE |