| Title: |
Drug Incompatibilities and Complex Assemblies: Let Us Remain Vigilant! |
| Authors: |
Salomez-Ihl, Cordélia; Martin Mena, Anthony; Molina, M. C.; Chapuis, R.; Durand, M.; Chanoine, S.; Leenhardt, J.; Py, P.; Brunet, M. D.; Wong, Y. S.; Chevallier, M.; Décaudin, Bertrand; Odou, Pascal; Bedouch, P.; Mazet, R. |
| Contributors: |
CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble (CHUGA); Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 (GRITA); Université de Lille-Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille) |
| Source: |
Pharmaceuticals ; https://lilloa.hal.science/hal-05153602 ; Pharmaceuticals, 2025, Pharmaceuticals, 18 (5), pp.626. ⟨10.3390/ph18050626⟩ |
| Publisher Information: |
CCSD |
| Publication Year: |
2025 |
| Collection: |
LillOA (HAL Lille Open Archive, Université de Lille) |
| Subject Terms: |
multi-lumen infusion devices; ganciclovir; parenteral nutrition; neonatal care units; drug infusion systems; drug incompatibilities; [SDV]Life Sciences [q-bio] |
| Description: |
International audience ; Background/Objectives: Multi-lumen devices that limit physicochemical incompatibilities (PCIs) are frequently used in neonatal intensive care units where premature infants receive numerous infusions. The aim of the study was to investigate a PCI that occurred despite the use of a device of this type (EDELVAISS® Multiline NEO, Doran International, Toussieu, France). Case Summary: A 7-week-old preterm infant received ganciclovir at therapeutic dosage for cytomegalovirus (CMV) infection. After the fifth administration of ganciclovir, a PCI occurred, leading to a white precipitate. The peripheral inserted central catheter (PICC) (PREMICATH®2Fr, Vygon, Ecouen, France) had to be replaced. Laboratory reproduction of the administrations during 72 h, nuclear magnetic resonance (NMR) analysis and particle counting were carried out to analyse the occurrence of events leading to PCIs. The precipitate was linked to a PCI of parenteral nutrition associated with a dilution error of ganciclovir (omission of a 10-fold dilution step, resulting in ganciclovir being administered at 30 mg/L instead of 3 mg/L). Due to the presence of lipids in the parenteral nutrition, visual detection of the white precipitate was difficult. Conclusions: Multi-lumen infusion devices limit but do not prevent the occurrence of PCIs, particularly in the event of a preparation error. Despite the use of this type of device, great vigilance is still required, particularly with regard to prescription analysis and reconstitution procedures. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/40430447; PUBMED: 40430447 |
| DOI: |
10.3390/ph18050626 |
| Availability: |
https://lilloa.hal.science/hal-05153602; https://lilloa.hal.science/hal-05153602v1/document; https://lilloa.hal.science/hal-05153602v1/file/pharmaceuticals-18-00626-v2.pdf; https://doi.org/10.3390/ph18050626 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.A16BDAAE |
| Database: |
BASE |