| Title: |
Subsequent Chemotherapy and Treatment Patterns After Abiraterone Acetate in Patients with Metastatic Castration-resistant Prostate Cancer: Post Hoc Analysis of COU-AA-302. |
| Authors: |
de Bono, JS; Smith, MR; Saad, F; Rathkopf, DE; Mulders, PFA; Small, EJ; Shore, ND; Fizazi, K; De Porre, P; Kheoh, T; Li, J; Todd, MB; Ryan, CJ; Flaig, TW |
| Contributors: |
De Bono, Johann |
| Publisher Information: |
ELSEVIER |
| Publication Year: |
2016 |
| Collection: |
The Institute of Cancer Research (ICR): Publications Repository |
| Subject Terms: |
Humans; Carcinoma; Neoplasm Metastasis; Taxoids; Prednisone; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Disease-Free Survival; Survival Rate; Age Factors; Adult; Aged; 80 and over; Middle Aged; Male; Prostatic Neoplasms; Castration-Resistant; Practice Patterns; Physicians'; Abiraterone Acetate; Docetaxel |
| Description: |
BACKGROUND: Treatment patterns for metastatic castration-resistant prostate cancer (mCRPC) have changed substantially in the last few years. In trial COU-AA-302 (chemotherapy-naïve men with mCRPC), abiraterone acetate plus prednisone (AA) significantly improved radiographic progression-free survival and overall survival (OS) when compared to placebo plus prednisone (P). OBJECTIVE: This post hoc analysis investigated clinical responses to docetaxel as first subsequent therapy (FST) among patients who progressed following protocol-specified treatment with AA, and characterized subsequent treatment patterns among older (≥75 yr) and younger ( |
| Document Type: |
article in journal/newspaper |
| File Description: |
Print-Electronic; 664; application/pdf |
| Language: |
English |
| ISSN: |
1873-7560; 0302-2838 |
| Relation: |
European urology, 2017, 71 (4), pp. 656 - 664; https://repository.icr.ac.uk/handle/internal/98 |
| DOI: |
10.1016/j.eururo.2016.06.033 |
| Availability: |
https://doi.org/10.1016/j.eururo.2016.06.033; https://repository.icr.ac.uk/handle/internal/98 |
| Rights: |
https://creativecommons.org/licenses/by-nc-nd/4.0 |
| Accession Number: |
edsbas.A17F994A |
| Database: |
BASE |