| Title: |
Nonthyroidal illness syndrome. to treat or not to treat? Have we answered the question? A review of metanalyses |
| Authors: |
Sciacchitano, Salvatore; Capalbo, Carlo; Napoli, Christian; Anibaldi, Paolo; Salvati, Valentina; De Vitis, Claudia; Mancini, Rita; Coluzzi, Flaminia; Rocco, Monica |
| Contributors: |
Sciacchitano, Salvatore; Capalbo, Carlo; Napoli, Christian; Anibaldi, Paolo; Salvati, Valentina; De Vitis, Claudia; Mancini, Rita; Coluzzi, Flaminia; Rocco, Monica |
| Publication Year: |
2022 |
| Collection: |
Sapienza Università di Roma: CINECA IRIS |
| Subject Terms: |
nonthyroidal illness syndrome; SARS-CoV-2 (2019-nCoV) coronaviru; bioelectrical impedance analysi; hydration; sodium/potassium exchangeable ratio |
| Description: |
Methods: We performed a review of the metanalyses focused on NTIS in critically ill patients. After a careful selection, we extracted data from four metanalyses, performed in different clinical conditions and diseases. In particular, we analyzed the type of TH supplementation, the route of administration, the dosages and duration of treatment and the outcomes chosen to evaluate the results. Results: We observed a marked heterogeneity among the IRCTs, in terms of type of TH supplementation, route of administration, dosages and duration of treatment. We also found great variability in the primary outcomes, such as prevention of neurological alterations, reduction of oxygen requirements, restoration of endocrinological and clinical parameters and reduction of mortality. Conclusions: NTIS is a frequent finding in critical ill patients. Despite several available IRCTs, it is still unclear whether NTIS should be treated or not. New primary endpoints should be identified to adequately validate the efficacy of TH treatment and to obtain a clear answer to the question raised some years ago. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/wos/WOS:000803966700001; volume:13; firstpage:1; lastpage:9; numberofpages:9; journal:FRONTIERS IN ENDOCRINOLOGY; http://hdl.handle.net/11573/1635032 |
| DOI: |
10.3389/fendo.2022.850328 |
| Availability: |
http://hdl.handle.net/11573/1635032; https://doi.org/10.3389/fendo.2022.850328 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.A1889830 |
| Database: |
BASE |