| Title: |
Genome-wide association study of Tourette's syndrome |
| Authors: |
Scharf, JM; Yu, D; Mathews, CA; Neale, BM; Stewart, SE; Fagerness, JA; Evans, P; Gamazon, E; Edlund, CK; Service, SK; Tikhomirov, A; Osiecki, L; Illmann, C; Pluzhnikov, A; Konkashbaev, A; Davis, LK; Han, B; Crane, J; Moorjani, P; Crenshaw, AT; Parkin, MA; Reus, VI; Lowe, TL; Rangel-Lugo, M; Chouinard, S; Dion, Y; Girard, S; Cath, DC; Smit, JH; King, RA; Fernandez, TV; Leckman, JF; Kidd, KK; Kidd, JR; Pakstis, AJ; State, MW; Herrera, LD; Romero, R; Fournier, E; Sandor, P; Barr, CL; Phan, N; Gross-Tsur, V; Benarroch, F; Pollak, Y; Budman, CL; Bruun, RD; Erenberg, G; Naarden, AL; Lee, PC; Weiss, N; Kremeyer, B; Berrío, GB; Campbell, DD; Cardona Silgado, JC; Ochoa, WC; Mesa Restrepo, SC; Muller, H; Valencia Duarte, AV; Lyon, GJ; Leppert, M; Morgan, J; Weiss, R; Grados, MA; Anderson, K; Davarya, S; Singer, H; Walkup, J; Jankovic, J; Tischfield, JA; Heiman, GA; Gilbert, DL; Hoekstra, PJ; Robertson, MM; Kurlan, R; Liu, C; Gibbs, JR; Singleton, A; Hardy, J; Strengman, E; Ophoff, RA; Wagner, M; Moessner, R; Mirel, DB; Posthuma, D; Sabatti, C; Eskin, E; Conti, DV; Knowles, JA; Ruiz-Linares, A; Rouleau, GA; Purcell, S; Heutink, P; Oostra, BA; McMahon, WM; Freimer, NB; Cox, NJ; Pauls, DL |
| Source: |
Molecular Psychiatry, vol 18, iss 6 |
| Publisher Information: |
eScholarship, University of California |
| Publication Year: |
2013 |
| Collection: |
University of California: eScholarship |
| Subject Terms: |
32 Biomedical and Clinical Sciences (for-2020); 5202 Biological Psychology (for-2020); 5203 Clinical and Health Psychology (for-2020); 3202 Clinical Sciences (for-2020); 52 Psychology (for-2020); Neurodegenerative (rcdc); Mental Health (rcdc); Human Genome (rcdc); Genetics (rcdc); Brain Disorders (rcdc); Neurosciences (rcdc); Tourette Syndrome (rcdc); 2.1 Biological and endogenous factors (hrcs-rac); Adolescent (mesh); Adult (mesh); Attention Deficit Disorder with Hyperactivity (mesh); Case-Control Studies (mesh); Chromosomes; Human; Pair 9 (mesh); Female (mesh); Fibrillar Collagens (mesh); Genetic Predisposition to Disease (mesh); Genome-Wide Association Study (mesh); Genotype (mesh); Humans (mesh); International Cooperation (mesh); Male (mesh); Meta-Analysis as Topic (mesh); Obsessive-Compulsive Disorder (mesh) |
| Subject Geographic: |
721 - 728 |
| Description: |
Tourette's syndrome (TS) is a developmental disorder that has one of the highest familial recurrence rates among neuropsychiatric diseases with complex inheritance. However, the identification of definitive TS susceptibility genes remains elusive. Here, we report the first genome-wide association study (GWAS) of TS in 1285 cases and 4964 ancestry-matched controls of European ancestry, including two European-derived population isolates, Ashkenazi Jews from North America and Israel and French Canadians from Quebec, Canada. In a primary meta-analysis of GWAS data from these European ancestry samples, no markers achieved a genome-wide threshold of significance (P |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
qt037352cw; https://escholarship.org/uc/item/037352cw; https://escholarship.org/content/qt037352cw/qt037352cw.pdf |
| DOI: |
10.1038/mp.2012.69 |
| Availability: |
https://escholarship.org/uc/item/037352cw; https://escholarship.org/content/qt037352cw/qt037352cw.pdf; https://doi.org/10.1038/mp.2012.69 |
| Rights: |
public |
| Accession Number: |
edsbas.A1E59A84 |
| Database: |
BASE |