| Title: |
How the cognitive reserve interacts with β-amyloid deposition in mitigating FDG metabolism: An observational study |
| Authors: |
Carapelle, Elena; Serra, Laura; Modoni, Sergio; Falcone, Michele; Caltagirone, Carlo; Bozzali, Marco; Specchio, Luigi Maria; Avolio, Carlo |
| Publisher Information: |
Lippincott, Williams & Wilkins |
| Publication Year: |
2017 |
| Collection: |
University of Sussex: Sussex Research Online |
| Subject Terms: |
RC0346 Neurology. Diseases of the nervous system Including speech disorders |
| Description: |
This observational study had the aim to assess the interaction between cognitive reserve (CR) and cerebrospinal fluid β-amyloid1-42 (Aβ1-42) in modulating brain [18F]fluorodeoxyglucose positron emission tomography (FDG-PET) metabolism in patients with moderate Alzheimer disease (AD).Twenty-seven patients with probable AD and 25 neurological normal subjects (NNS) entered the study. All participants had an FDG-PET scan, and AD patients also received a lumbar puncture to measure Aβ1-42, 181p-tau, and Tau concentrations. Based on years of formal education, AD patients were classified as highly educated-AD (years of formal education >5) or less educated-AD (years of formal education |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| ISSN: |
1536-5964 |
| Relation: |
http://sro.sussex.ac.uk/id/eprint/72896/1/How%20the%20cognitive%20reserve%20interacts%20with%20B-amyloid%20deposition%20in%20mitigating%20FDG%20metabolism.pdf; Carapelle, Elena, Serra, Laura, Modoni, Sergio, Falcone, Michele, Caltagirone, Carlo, Bozzali, Marco, Specchio, Luigi Maria and Avolio, Carlo (2017) How the cognitive reserve interacts with β-amyloid deposition in mitigating FDG metabolism: An observational study. Medicine, 96 (16). e5876. ISSN 1536-5964 |
| DOI: |
10.1097/MD.0000000000005876 |
| Availability: |
http://sro.sussex.ac.uk/id/eprint/72896/; http://sro.sussex.ac.uk/id/eprint/72896/1/How%20the%20cognitive%20reserve%20interacts%20with%20B-amyloid%20deposition%20in%20mitigating%20FDG%20metabolism.pdf; https://doi.org/10.1097/MD.0000000000005876 |
| Rights: |
cc_by_nc_nd_4 |
| Accession Number: |
edsbas.A2598A2F |
| Database: |
BASE |