| Title: |
HGG-49. Gliomatosis cerebri in children: A collaborative report from the European Society for Pediatric Oncology (SIOPE) |
| Authors: |
Nussbaumer, Gunther; Benesch, Martin; Gielen, Gerrit; Castel, David; Grill, Jacques; Alonso Roldán, Marta; Antonelli, Manila; Bailey, Simon; Baugh, Joshua; Biassoni, Veronica; Carai, Andrea; Colditz, Niclas; Colefati, Giovanni Stefania; Corbacioglu, Selim; Crampsie, Shauna; Entz-Werle, Natacha; Eyrich, Matthias; Frühwald, Michael; Garrè, Maria Luisa; Gerber, Nicolas; Giangaspero, Felice; Gil-Da-Costa, Maria João; Grabovska, Yura; Graf, Norbert; Hargrave, Darren; Hauser, Peter; Hoffmann, Marion; Hulleman, Esther; Jacobs, Sandra; Karremann, Michael; Kattamis, Antonis; Kebudi, Rejin; Kortmann, Rolf-Dieter; Kwiecien, Robert; Mackay, Alan; Massimino, Maura; Miele, Evelina; Mastronuzzi, Angela; Morana, Giovanni; Noack, Claudia; Pentikainen, Virve; Perwein, Thomas; Pfister, Stefan; Pietsch, Torsten; Roka, Kleoniki; Rossi, Sabrina; Rutkowski, Stefan; Schiavello, Elisabetta; Štěrba, Jaroslav; Sturm, Dominik; Sumerauer, David; Temelso, Sara; van Vuurden, Dannis; Varlet, Pascale; Veldhuijzen van Zanten, Sophie; Vinci, Maria; von Bueren, André; Warmuth-Metz, Monika; Wesseling, Pieter; Wiese, Maria; Wolff, Johannes; Zamecnik, Josef; Jones, David; Bison, Brigitte; La Madrid, Andrés Morales; Jones, Chris; Kramm, Christof |
| Contributors: |
Prédicteurs moléculaires et nouvelles cibles en oncologie (PMNCO (U981)); Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay; Département de cancérologie de l'enfant et de l'adolescent Gustave Roussy; Institut Gustave Roussy (IGR); Newcastle University Newcastle; Universität Regensburg = University of Regensburg = Université de Ratisbonne Allemagne (UR); Laboratoire de Bioimagerie et Pathologies (LBP); Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS); Département d'Oncologie et Hématologie Strasbourg; Hôpitaux Universitaires de Strasbourg (HUS); Centro di Neuro-Oncologia, Istituto Giannina Gaslini, 16147 Genoa, Italy |
| Source: |
20th International Symposium on Pediatric Neuro- Oncology (ISPNO 2022); https://hal.science/hal-04500749; 20th International Symposium on Pediatric Neuro- Oncology (ISPNO 2022), Jun 2022, Hamburg, Germany. 24 (Supplement_1), pp.i72-i73, 2022, ⟨10.1093/neuonc/noac079.264⟩ |
| Publisher Information: |
CCSD |
| Publication Year: |
2022 |
| Subject Terms: |
[SDV]Life Sciences [q-bio] |
| Subject Geographic: |
Hamburg; Germany |
| Description: |
International audience ; Abstract BACKGROUND: Gliomatosis cerebri (GC), a radiologically defined diffusely infiltrating glioma, is no longer considered a distinct entity since the 2016 WHO classification for tumors of the CNS. Due to its rarity and dismal prognosis treatment recommendations in children remain ambiguous. Using central neuroradiological review, we performed a multi-institutional, retrospective study of GC providing comprehensive radiological, clinical, and (epi)genetic characterization. RESULTS: We included 104 patients between 1-19 years. Within a median follow-up of 15.5 months (range, 2.3-138.8), 93 patients (89.4 %) had died, 4 (3.8 %) were lost to follow-up and 7 (6.8 %) were alive with stable/progressive disease. Median progression-free- (PFS) and overall survival (OS) were 8.6 months (interquartile range, 4.3-14.0) and 15.5 months (10.9-27.7), respectively. Former WHO grading correlated significantly with median OS: WHO °II: 47.8 months (25.2-55.7); WHO °III: 15.9 months (11.4-26.3); WHO °IV: 10.4 months (8.8-14.4) (p |
| Document Type: |
conference object; still image |
| Language: |
English |
| DOI: |
10.1093/neuonc/noac079.264 |
| Availability: |
https://hal.science/hal-04500749; https://doi.org/10.1093/neuonc/noac079.264 |
| Accession Number: |
edsbas.A26A35EF |
| Database: |
BASE |