| Title: |
Identifying Predictors for the Acquisition of Tolerance to Cow’s Milk Protein in Infants with Food Protein-Induced Allergic Proctocolitis (FPIAP): Multifactorial Analysis of Two Italian Cohorts |
| Authors: |
Scavella A.; Ferrigno C.; Bau M.; Colombo A.; Tavernelli C. I.; Zobele M.; Borgetto R.; Maggi A.; Baronti A.; Francone A.; Zuccotti G. V.; Agosti M.; D'Auria E.; Salvatore S. |
| Contributors: |
Scavella, A.; Ferrigno, C.; Bau, M.; Colombo, A.; Tavernelli, C. I.; Zobele, M.; Borgetto, R.; Maggi, A.; Baronti, A.; Francone, A.; Zuccotti, G. V.; Agosti, M.; D'Auria, E.; Salvatore, S. |
| Publication Year: |
2026 |
| Collection: |
IRInSubria - Institutional Repository Insubria (Università degli Studi dell’Insubria) |
| Subject Terms: |
cow’s milk; elimination diet; food protein-induced allergic proctocoliti; food tolerance; FPIAP; infant; non-IgE-mediated food allergy; rectal bleeding |
| Description: |
Background/Objectives: Food protein-induced allergic proctocolitis (FPIAP) is a non-IgE-mediated gastrointestinal food allergy. Although tolerance to the culprit food is usually achieved within the first year of life, late acquisition occurs and remains poorly predictable. This study aimed to analyze clinical characteristics and explore factors that may potentially function as predictors of late tolerance acquisition to cow’s milk (CM). Methods: We conducted a cross-sectional study at two Italian pediatric clinics (2020–2024), including infants diagnosed with FPIAP. Clinical, dietary, and immunological variables; onset and duration of rectal bleeding (visible blood in the stools); and time to CM tolerance were analyzed. Late tolerance was defined as acquisition after 19 months according to the distribution of tolerance achievement in our population. Statistical analyses included χ2, Mann–Whitney U, Spearman’s correlation, and logistic regression. Results: Ninety-four infants were included (median age at onset 2.9 months [IQR 1.9–4.7]); 58 (62%) were exclusively breastfed and 18 (19%) were born preterm (18 days before elimination diet (OR 5.9 [1.3–27.7]; p = 0.023), and IgE sensitization (OR 6.4 [1.2–35.0]; p = 0.034) as factors that may potentially function as predictors of late tolerance acquisition to CM. Conclusions: Identification of factors that may potentially function as predictors of late tolerance acquisition to CM in infants with FPIAP may help ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
ELETTRONICO |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/41515212; info:eu-repo/semantics/altIdentifier/wos/WOS:001658607800001; volume:18; issue:1; firstpage:1; lastpage:17; numberofpages:17; journal:NUTRIENTS; https://hdl.handle.net/11383/2206332 |
| DOI: |
10.3390/nu18010095 |
| Availability: |
https://hdl.handle.net/11383/2206332; https://doi.org/10.3390/nu18010095 |
| Rights: |
info:eu-repo/semantics/openAccess ; license:Creative commons ; license uri:http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.A26DF4A9 |
| Database: |
BASE |