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Association of Chromosome 9p21 With Subsequent Coronary Heart Disease Events : A GENIUS-CHD Study of Individual Participant Data

Title:	Association of Chromosome 9p21 With Subsequent Coronary Heart Disease Events : A GENIUS-CHD Study of Individual Participant Data
Authors:	Patel, Riyaz S.; Schmidt, Amand F.; Tragante, Vinicius; McCubrey, Raymond O.; Holmes, Michael, V; Howe, Laurence J.; Direk, Kenan; Åkerblom, Axel; Leander, Karin; Virani, Salim S.; Kaminski, Karol A.; Muehlschlegel, Jochen D.; Dube, Marie-Pierre; Allayee, Hooman; Almgren, Peter; Alver, Maris; Baranova, Ekaterina, V; Behlouli, Hassan; Boeckx, Bram; Braund, Peter S.; Breitling, Lutz P.; Delgado, Graciela; Duarte, Nubia E.; Dufresne, Line; Eriksson, Niclas; Foco, Luisa; Gijsberts, Crystel M.; Gong, Yan; Hartiala, Jaana; Heydarpour, Mahyar; Hubacek, Jaroslav A.; Kleber, Marcus; Kofink, Daniel; Kuukasjarvi, Pekka; Lee, Vei-Vei; Leiherer, Andreas; Lenzini, Petra A.; Levin, Daniel; Lyytikainen, Leo-Pekka; Martinelli, Nicola; Mons, Ute; Nelson, Christopher P.; Nikus, Kjell; Pilbrow, Anna P.; Ploski, Rafal; Sun, Yan, V; Tanck, Michael W. T.; Tang, W. H. Wilson; Trompet, Stella; van der Laan, Sander W.; van Setten, Jessica; Vilmundarson, Ragnar O.; Anselmi, Chiara Viviani; Vlachopoulou, Efthymia; Boerwinkle, Eric; Briguori, Carlo; Carlquist, John F.; Carruthers, Kathryn F.; Casu, Gavino; Deanfield, John; Deloukas, Panos; Dudbridge, Frank; Fitzpatrick, Natalie; Gigante, Bruna; James, Stefan; Lokki, Marja-Liisa; Lotufo, Paulo A.; Marziliano, Nicola; Mordi, Ify R.; Muhlestein, Joseph B.; Cheh, Chris Newton; Pitha, Jan; Saely, Christoph H.; Samman-Tahhan, Ayman; Sandesara, Pratik B.; Teren, Andrej; Timmis, Adam; Van de Werf, Frans; Wauters, Els; Wilde, Arthur A. M.; Ford, Ian; Stott, David J.; Algra, Ale; Andreassi, Maria G.; Ardissino, Diego; Arsenault, Benoit J.; Ballantyne, Christie M.; Bergmeijer, Thomas O.; Bezzina, Connie R.; Body, Simon C.; Bogaty, Peter; de Borst, Gert J.; Brenner, Hermann; Burkhardt, Ralph; Carpeggiani, Clara; Condorelli, Gianluigi; Cooper-DeHoff, Rhonda M.; Cresci, Sharon; de Faire, Ulf; Doughty, Robert N.; Drexel, Heinz; Engert, James C.; Fox, Keith A. A.; Girelli, Domenico; Hagström, Emil; Hazen, Stanley L.; Held, Claes; Hemingway, Harry; Hoefer, Imo E.; Hovingh, G. Kees; Johnson, Julie A.; De Jong, Pim A.; Jukema, J. Wouter; Kaczor, Marcin P.; Kahonen, Mika; Kettner, Jiri; Kiliszek, Marek; Klungel, Olaf H.; Lagerqvist, Bo; Lambrechts, Diether; Laurikka, Jari O.; Lehtimaki, Terho; Lindholm, Daniel; Mahmoodi, Bakhtawar K.; Maitland-van der Zee, Anke H.; McPherson, Ruth; Melander, Olle; Metspalu, Andres; Pepinski, Witold; Olivieri, Oliviero; Opolski, Grzegorz; Palmer, Colin N.; Pasterkamp, Gerard; Pepine, Carl J.; Pereira, Alexandre C.; Note, Louise; Quyyumi, Arshed A.; Richards, A. Mark; Sanak, Marek; Scholz, Markus; Siegbahn, Agneta; Sinisalo, Juha; Smith, J. Gustav; Spertus, John A.; Stewart, Alexandre F. R.; Szczeklik, Wojciech; Szpakowicz, Anna; ten Berg, Jurrien M.; Thanassoulis, George; Thieiy, Joachim; van der Graaf, Yolanda; Visseren, Frank L. J.; Waltenberger, Johannes; Van der Harst, Pim; Tardif, Jean-Claude; Sattar, Naveed; Lang, Chim C.; Pare, Guillaume; Brophy, James M.; Anderson, Jeffrey L.; Maerz, Winfried; Wallentin, Lars; Cameron, Vicky A.; Horne, Benjamin D.; Samani, Nilesh J.; Hingorani, Aroon D.; Asselbergs, Folkert W.
Publisher Information:	Uppsala universitet, Uppsala kliniska forskningscentrum (UCR); Uppsala universitet, Kardiologi; Uppsala universitet, Klinisk kemi; UCL, Inst Cardiovasc Sci, Fac Populat Hlth Sci, London, England;St Bartholomews Hosp, Barts Heart Ctr, London, England; UCL, Inst Cardiovasc Sci, Fac Populat Hlth Sci, London, England;UMC, Dept Cardiol, Div Heart & Lungs, Utrecht, Netherlands; UMC, Dept Cardiol, Div Heart & Lungs, Utrecht, Netherlands; Intertermt Med Ctr, Intermt Heart Inst, Salt Lake City, UT USA; Univ Oxford, Clin Trial Serv Unit, Nuffield Dept Populat Hlth, Oxford, England;Univ Oxford, Epidemiol Studies Unit, Nuffield Dept Populat Hlth, Oxford, England;Univ Oxford, Med Res Council Populat Hlth Res Unit, Oxford, England;Univ Oxford, Natl Inst Hlth Res, Oxford Biomed Res Ctr, Oxford, England; UCL, Inst Cardiovasc Sci, Fac Populat Hlth Sci, London, England; Karolinska Inst, Inst Environm Med, Stockholm, Sweden; Baylor Coll Med, Sect Cardiovasc Res, Michael & DeBakey Vet Affairs Med Ctr, Sect Cardiol, Houston, TX 77030 USA;Baylor Coll Med, Dept Med, Sect Cardiol, Houston, TX 77030 USA; Med Univ Bialystok, Dept Populat Med & Civilizat Dis Prevent, Bialystok, Poland;Med Univ Bialystok, Dept Cardiol, Bialystok, Poland; UCL, Inst Cardiovasc Sci, Fac Populat Hlth Sci, London, England;St Bartholomews Hosp, Barts Heart Ctr, London, England;Harvard Med Sch, 75 Francis St, Boston, MA 02115 USA; Univ Montreal, Fac Med, Montreal, PQ, Canada; USC, Dept Prevent Med, Los Angeles, CA USA;USC, Dept Biochem & Mol Med, Los Angeles, CA USA; Lund Univ, Dept Clin Sci, Malmo, Sweden; Univ Tartu, Inst Mol & Cell Biol, Dept Biotechnol, Tartu, Estonia; Univ Med Ctr, Div Pharmacoepidemiol & Clin Pharmacol, Utrecht, Netherlands; McGill Univ Hlth Ctr, Res Inst, Montreal, PQ, Canada;German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany; Katholieke Univ Leuven, Dept Human Genet, Lab Translat Genet, Leuven, Belgium;VIB, VIB Ctr Canc Biol, Lab Translat Genet, Ghent, Belgium; Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England;Univ Leicester, Dept Hlth Sci, Leicester, Leics, England;Glenfield Hosp, NIHR, Leicester, Leics, England; Heidelberg Univ, Med Fac Mannheim, Dept Med 5, Mannheim, Germany; Univ Sao Paulo, Heart Inst, Sao Paulo, Brazil; McGill Univ Hlth Ctr, Res Inst, Montreal, PQ, Canada;McGill Univ Hlth Ctr, Prevent & Genom Cardiol, Montreal, PQ, Canada; Univ Lubeck, Affiliated Inst, Eurac Res, Inst Biomed, Bolzano, Italy; UMC, Lab Expt Cardiol, Utrecht, Netherlands; Univ Florida, Dept Pharmacotherapy & Translat Res, Gainesville, FL USA;Univ Florida, Ctr Pharmacogen, Gainesville, FL USA; USC, Dept Prevent Med, Los Angeles, CA USA;USC, Dept Biochem & Mol Med, Los Angeles, CA USA;USC, Keck Sch Med, Inst Genet Med, Los Angeles, CA USA; Brigham & Womens Hosp, Dept Anesthesiol Perioperat & Pain Med, 75 Francis St, Boston, MA 02115 USA;Harvard Med Sch, 75 Francis St, Boston, MA 02115 USA; Inst Clin & Expt Med, Ctr Expt Med, Prague, Czech Republic; Univ Tampere, Fac Med & Life Sci, Finnish Cardiovasc Res Ctr, Dept Cardiothorac Surg, Tampere, Finland; Texas Heart Inst, Dept Biostat & Epidemiol, Houston, TX 77025 USA; VIVIT, Feldkirch, Austria;Private Univ Principal Liechtenstein, Triesen, Liechtenstein;Med Cent Labs, Feldkirch, Austria; Washington Univ, Sch Med, Dept Genet, Stat Genom Div, St Louis, MO 63110 USA;Univ Sao Paulo, Hosp Univ, Ctr Pesquisa Clin, Sao Paulo, Brazil; Univ Dundee, Sch Med, Div Mol & Clin Med, Dundee, Scotland; Univ Tampere, Fac Med & Life Sci, Finnish Cardiovasc Res Ctr, Dept Clin Chem, Tampere, Finland;Fimlab Labs, Dept Clin Chem, Tampere, Finland; Univ Verona, Dept Med, Verona, Italy; German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany; Univ Tampere, Fac Med & Life Sci, Finnish Cardiovasc Res Ctr, Dept Cardiol, Tampere, Finland;Tampere Univ Hosp, Dept Cardiol, Heart Ctr, Tampere, Finland; Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Sch Med, Atlanta, GA 30322 USA; Med Univ Warsaw, Dept Med Genet, Warsaw, Poland; Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Sch Med, Atlanta, GA 30322 USA;Emory Univ, Sch Med, Dept Biomed Informat, Atlanta, GA 30322 USA; Univ Utrecht, Dept Internal Med, Sect Gerontol & Geriatr, Utrecht, Netherlands; Cleveland Clin, Lerner Res Inst, Dept Cellular & Mol Med, Cleveland, OH 44106 USA;Cleveland Clin, Dept Cardiovasc Med, Heart & Vasc Inst & Ctr Microbiome & Human Hlth, Cleveland, OH 44106 USA; Univ Utrecht, Dept Internal Med, Sect Gerontol & Geriatr, Utrecht, Netherlands;Univ Utrecht, Dept Cardiol, Utrecht, Netherlands; Univ Med Ctr, Div Pharmacoepidemiol & Clin Pharmacol, Utrecht, Netherlands;Univ Utrecht, Div Labs Pharm & Biomed Genet, Leiden Univ Med Ctr, Lab Clin Chem & Hematol, Utrecht, Netherlands; ICIN Netherlands Heart Inst, Durrer Ctr Cardiogenet Res, Utrecht, Netherlands; Ruddy Canadian Cardiovasc Genet Ctr, Ottawa, ON, Canada;Univ Ottawa, Dept Biochem Microbiol & Immunol, Ottawa, ON, Canada; Humanitas Clin & Res Ctr, Dept Cardiovasc Med, Milan, Italy; Univ Helsinki, Transplantat Lab, Med, Helsinki, Finland; Univ Texas Houston, Sch Publ Hlth, Houston, TX USA; Clin Mediterranea, Naples, Italy; Intertermt Med Ctr, Intermt Heart Inst, Salt Lake City, UT USA;Univ Utah, Dept Internal Med, Cardiol Div, Salt Lake City, UT 84112 USA; Univ Edinburgh, Cardiovasc Sci, Edinburgh, Midlothian, Scotland; ATS Sardegna, ASL 3, Nuoro, Italy; INESSS, Unite Evaluat Cardiovasc, Montreal, PQ, Canada; Barts & London Med Sch, William Harvey Res Inst, London, England;Queen Mary Univ London, Ctr Genom Hlth, London, England; BHF Cardiovasc Res Ctr, Leicester, Leics, England; UCL, Inst Hlth Informat, Fac Populat Hlth Sci, London, England; UMC, Dept Clin Chem & Hematol, Utrecht, Netherlands; Jagiellonian Univ, Med Coll, Dept Internal Med, Krakow, Poland; Univ Utah, Dept Internal Med, Cardiol Div, Salt Lake City, UT 84112 USA; Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston & Program Med & Populat Genet, Brd Inst, Cambridge, MA USA;Massachusetts Gen Hosp, Ctr Human Genet Res, Boston & Program Med & Populat Genet, Brd Inst, Cambridge, MA USA; UCL, Inst Hlth Informat, Fac Populat Hlth Sci, London, England;VIVIT, Feldkirch, Austria;Private Univ Principal Liechtenstein, Triesen, Liechtenstein; Emory Univ, Sch Med, Dept Med, Emory Clin Cardiovasc Res Inst, Atlanta, GA USA; Heart Ctr Leipzig, Acad Teaching Hosp Feldkirch, Dept Med & Cardiol, Leipzig, Germany;Univ Leipzig, LIFE Res Ctr Civilizat Dis, Leipzig, Germany; UCL, Inst Hlth Informat, Fac Populat Hlth Sci, London, England;St Bartholomews Hosp, Barts Heart Ctr, London, England; Katholieke Univ Leuven, Dept Cardiovasc Sci, Leuven, Belgium; Katholieke Univ Leuven, Univ Hosp, Dept Resp Med, Resp Oncol Unit, Leuven, Belgium; Princess Jawhara Brah Ctr Excellence Res Heredita, Jeddah, Saudi Arabia; Univ Glasgow, Robertson Ctr Biostat, Glasgow, Lanark, Scotland; Univ Glasgow, Inst Cardiovasc & Med Sci, Glasgow, Lanark, Scotland; Univ Med Ctr, Dept Neurol & Neurosurg, Brain Ctr Rudolf Magnus, Utrecht, Netherlands;Univ Med Ctr, Dept Neurol & Neurosurg, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands; CNR, Inst Clin Physiol, Pisa, Italy; Parma Univ Hosp, Cardiol Dept, Parma, OH USA; Inst Univ cardiol & Pneumol Quebec, Ctr Rech, Quebec City, PQ, Canada;Univ Laval, Fac Med, Dept Med, Laval, PQ, Canada; St Antonius Hosp, Dept Cardiol, Nieuwegein, Netherlands; Univ Amsterdam, Clin Epidemiol & Biostat, AMC Heart Ctr, Amsterdam, Netherlands; Harvard Med Sch, 75 Francis St, Boston, MA 02115 USA;Beth Israel Deaconess Med Ctr, Dept Anesthesia Pain & Crit Care, Boston, MA 02215 USA; Inst Univ Cardiol & Pneumol Quebec, Dept Multidisciplinaire Cardiol, Serv Cardiol, Quebec City, PQ, Canada;INESSS, Unite Evaluat Cardiovasc, Montreal, PQ, Canada;Laval Univ, Inst Univ Cardiol & Pnemol Quebec, Quebec City, PQ, Canada; Univ Utrecht, Univ Med Ctr Utrecht, Dept Vasc Surg, Utrecht, Netherlands; Univ Leipzig, LIFE Res Ctr Civilizat Dis, Leipzig, Germany;Univ Hosp Regensburg, Inst Clin Chem & Lab Med, Regensburg, Germany; Humanitas Clin & Res Ctr, Dept Cardiovasc Med, Milan, Italy;Humanitas Univ, Dept Biomed Sci, Milan, Italy; Washington Univ, Sch Med, Dept Genet, Stat Genom Div, St Louis, MO 63110 USA;Washington Univ, Sch Med, Dept Med, Cardiovasc Div, St Louis, MO 63110 USA; Univ Auckland, Heart Hlth Res Grp, Auckland, New Zealand; VIVIT, Feldkirch, Austria;Private Univ Principal Liechtenstein, Triesen, Liechtenstein;Drexel Univ, Coll Med, Philadelphia, PA USA; McGill Univ Hlth Ctr, Res Inst, Montreal, PQ, Canada;Royal Victoria Hosp, Dept Med, Div Cardiol, Montreal, PQ, Canada;McGill Univ Hlth Ctr, Prevent & Genom Cardiol, Montreal, PQ, Canada; Univ Edinburgh, Cardiol, Edinburgh, Midlothian, Scotland; Cleveland Clin, Lerner Res Inst, Dept Cellular & Mol Med, Cleveland, OH 44106 USA;Cleveland Clin, Dept Cardiovasc Med, Heart & Vasc Inst, Cleveland, OH 44106 USA;Cleveland Clin, Dept Cardiovasc Med, Ctr Microbiome & Human Hlth, Cleveland, OH 44106 USA; Acad Med Ctr, Dept Vasc Med, Amsterdam, Netherlands; Univ Florida, Dept Pharmacotherapy & Translat Res, Gainesville, FL USA;Univ Florida, Ctr Pharmacogen, Gainesville, FL USA;Univ Florida, Coll Med, Div Cardiovasc Med, Gainesville, FL USA; Univ Med Ctr, Dept Radiol, Utrecht, Netherlands; Univ Utrecht, Dept Cardiol, Utrecht, Netherlands;Inter Univ, Cardiol Inst Netherlands, Utrecht, Netherlands; Univ Tampere, Fac Med & Life Sci, Finnish Cardiovasc Res Ctr, Dept Clin Physiol, Tampere, Finland;Tampere Univ Hosp, Dept Clin Physiol, Tampere, Finland; Inst Clin & Expt Med, Cardiol Ctr, Prague, Czech Republic; Mil Inst Med, Dept Cardiol & Internal Dis, Warsaw, Poland; Katholieke Univ Leuven, Dept Human Genet, Lab Translat Genet, Leuven, Belgium; Univ Tampere, Fac Med & Life Sci, Finnish Cardiovasc Res Ctr, Dept Cardiothorac Surg, Tampere, Finland;Tampere Univ Hosp, Heart Ctr, Dept Cardiothorac Surg, Tampere, Finland; Univ Med Ctr, Div Pharmacoepidemiol & Clin Pharmacol, Utrecht, Netherlands;Univ Amsterdam, Acad Med Ctr, Dept Resp Med, Clin & Expt Cardiol, Amsterdam, Netherlands; Univ Ottawa Heart Inst, Ottawa, ON, Canada;Univ Ottawa, Dept Med, Ottawa, ON, Canada;Univ Ottawa, Dept Biochem, Ottawa, ON, Canada;Univ Ottawa, Dept Microbiol & Immunol, Ottawa, ON, Canada; Lund Univ, Dept Clin Sci, Malmo, Sweden;Skane Univ Hosp, Dept Internal Med, Malmo, Sweden; Univ Tartu, Estonian Genome Ctr, Inst Genom, Tartu, Estonia;Univ Tartu, Inst Mol & Cell Biol, Dept Biotechnol, Tartu, Estonia; Med Univ Bialystok, Dept Forens Med, Bialystok, Poland; Med Univ Warsaw, Dept Cardiol, Warsaw, Poland; Ninewells Hosp & Med Sch, Div Mol & Clin Med, Pat Macpherson Ctr Pharmacogenet & Pharmacogen, Dundee, Scotland; UMC, Dept Clin Chem, Utrecht, Netherlands; Univ Florida, Coll Med, Div Cardiovasc Med, Gainesville, FL USA; Humanitas Univ, Dept Biomed Sci, Milan, Italy; Univ Otago, Christchurch Heart Inst, Dunedin, New Zealand;Natl Univ Singapore, Cardiovasc Res Inst, Singapore, Singapore; Univ Leipzig, LIFE Res Ctr Civilizat Dis, Leipzig, Germany;Univ Leipzig, Inst Med Informat Stat & Epidemiol, Leipzig, Germany; Univ Helsinki, Helsinki Univ Hosp, Heart & Lung Ctr, Helsinki, Finland; Lund Univ, Dept Cardiol Clin Sci, Lund, Sweden;Skane Univ Hosp, Malmo, Sweden;Wallenberg Ctr Mol Med, Malmo, Sweden;Lund Univ, Lund Univ Diabet Ctr, Lund, Sweden; St Lukes Mid Amer Heart Inst, Kansas City, MO USA;Univ Missouri, St Lukes Hlth Syst, Kansas City, MO 64110 USA; Med Univ Bialystok, Dept Cardiol, Bialystok, Poland; Intertermt Med Ctr, Intermt Heart Inst, Salt Lake City, UT USA;St Antonius Hosp, Dept Cardiol, Nieuwegein, Netherlands; Med Univ Bialystok, Dept Forens Med, Bialystok, Poland;Royal Victoria Hosp, Dept Med, Div Cardiol, Montreal, PQ, Canada;McGill Univ Hlth Ctr, Prevent & Genom Cardiol, Montreal, PQ, Canada; Univ Leipzig, LIFE Res Ctr Civilizat Dis, Leipzig, Germany;Univ Hosp, Clin Chem & Mol Diagnost, Inst Lab Med, Leipzig, Germany; Univ Med Ctr, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands; McGill Univ Hlth Ctr, Ctr Outcomes Res & Evaluat, Res Inst, Montreal, PQ, Canada; Univ Munster, Dept Cardiovasc Med, Munster, Germany; Univ Groningen, Univ Med Ctr, Groningen, Netherlands; Univ Montreal, Montreal Heart Inst, Montreal, PQ, Canada;Univ Montreal, Fac Med, Montreal, PQ, Canada; McMaster Univ, Dept Pathol & Mol Med, Hamilton, ON, Canada;Populat Hlth Res Inst, Hamilton, ON, Canada; McGill Univ Hlth Ctr, Res Inst, Montreal, PQ, Canada; Heidelberg Univ, Med Fac Mannheim, Dept Med 5, Mannheim, Germany;Synlab Holding Deutschland GmbH, Synlab Acad, Mannheim, Germany;Med Univ Graz, Clin Inst Med, Graz, Austria;Med Univ Graz, Chem Lab Diagnost, Graz, Austria; Univ Otago, Christchurch Heart Inst, Dunedin, New Zealand; UMC, Lab Expt Cardiol, Utrecht, Netherlands;Univ Utah, Dept Biomed Informat, Salt Lake City, UT USA; Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England;Univ Leicester, Dept Hlth Sci, Leicester, Leics, England; UCL, Inst Cardiovasc Sci, Fac Populat Hlth Sci, London, England;UCL, Inst Hlth Informat, Fac Populat Hlth Sci, London, England;UMC, Dept Cardiol, Div Heart & Lungs, Utrecht, Netherlands
Publication Year:	2019
Collection:	Uppsala University: Publications (DiVA)
Subject Terms:	chromosome; genetic; variation; myocardial infarction; risk factor; secondary prevention; Cardiology and Cardiovascular Disease; Kardiologi och kardiovaskulära sjukdomar; Medical Genetics and Genomics; Medicinsk genetik och genomik
Description:	BACKGROUND: Genetic variation at chromosome 9p21 is a recognized risk factor for coronary heart disease (CHD). However, its effect on disease progression and subsequent events is unclear, raising questions about its value for stratification of residual risk. METHODS: A variant at chromosome 9p21 (rs1333049) was tested for association with subsequent events during follow-up in 103 357 Europeans with established CHD at baseline from the GENIUS-CHD (Genetics of Subsequent Coronary Heart Disease) Consortium (73.1% male, mean age 62.9 years). The primary outcome, subsequent CHD death or myocardial infarction (CHD death/myocardial infarction), occurred in 13 040 of the 93 115 participants with available outcome data. Effect estimates were compared with case/control risk obtained from the CARDIoGRAMplusC4D consortium (Coronary Artery Disease Genome-wide Replication and Meta-analysis [CARDIoGRAM] plus The Coronary Artery Disease [C4D] Genetics) including 47 222 CHD cases and 122 264 controls free of CHD. RESULTS: Meta-analyses revealed no significant association between chromosome 9p21 and the primary outcome of CHD death/myocardial infarction among those with established CHD at baseline (GENIUSCHD odds ratio, 1.02; 95% CI, 0.99-1.05). This contrasted with a strong association in CARDIoGRAMPlusC4D odds ratio 1.20; 95% CI, 1.18-1.22; P for interaction < 0.001 compared with the GENIUS-CHD estimate. Similarly, no clear associations were identified for additional subsequent outcomes, including all-cause death, although we found a modest positive association between chromosome 9p21 and subsequent revascularization (odds ratio, 1.07; 95% CI, 1.04-1.09). CONCLUSIONS: In contrast to studies comparing individuals with CHD to disease-free controls, we found no clear association between genetic variation at chromosome 9p21 and risk of subsequent acute CHD events when all individuals had CHD at baseline. However, the association with subsequent revascularization may support the postulated mechanism of chromosome 9p21 for ...
Document Type:	article in journal/newspaper
File Description:	application/pdf
Language:	English
Relation:	Circulation : Genomic and Precision Medicine, 2019, 12:4; info:eu-repo/grantAgreement/EC/FP7/201668; info:eu-repo/grantAgreement/EC/FP7/223004; PMID 30897348; ISI:000466741600005
DOI:	10.1161/CIRCGEN.119.002471
Availability:	http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-383874; https://doi.org/10.1161/CIRCGEN.119.002471
Rights:	info:eu-repo/semantics/openAccess
Accession Number:	edsbas.A290FE64
Database:	BASE