| Title: |
Effects of Intensive Blood Pressure Lowering on Brain Swelling in Thrombolyzed Acute Ischemic Stroke: The ENCHANTED Results |
| Authors: |
Zhang, Guobin; Chen, Chen; Ren, Xinwen; Zhao, Yang; Ouyang, Menglu; Billot, Laurent; Li, Qiang; Wang, Xia; Zhang, Luyun; Ong, Sheila; Liu, Leibo; You, Shoujiang; Lindley, Richard I.; Robinson, Thompson G.; Li, Gang; Chen, Xiaoying; Sui, Yi; Anderson, Craig S.; Song, Lili; Krause, M.; Priglinger, M.; Day, S.; Jala, S.; Davies, L.; Delcourt, C.; Carcel, C.; Malavera, A.; Ray, E.; Anderson, C.S.; Wijeratne, T.; Celestino, S.; Law, L.Y.; Ng, G.; Nagao, K.; Weiss, G.; Titton, N.; Batista, C.; Zãn, D.; Carbonera, L.; Ferreira, K.; Castro, R.; Martins Filho, R.K.; Carvalho, M.; Libardi, M.; Martins, G.; Fagundes, D.; Baron, G.; Boehringer, A.; Barbosa, J.; Bazan, R. |
| Source: |
Stroke ; volume 56, issue 6, page 1388-1395 ; ISSN 0039-2499 1524-4628 |
| Publisher Information: |
Ovid Technologies (Wolters Kluwer Health) |
| Publication Year: |
2025 |
| Description: |
BACKGROUND: Cerebral swelling in relation to cytotoxic edema is a predictor of poor outcome in acute ischemic stroke (AIS) and elevated blood pressure (BP) promotes its development. Whether intensive BP-lowering treatment reduces cerebral swelling is uncertain. We aimed to determine whether intensive BP lowering reduces the severity of cerebral swelling after thrombolysis for AIS. METHODS: A secondary analysis of the ENCHANTED (Enhanced Control of Hypertension and Thrombolysis Stroke Study), a partial factorial, international, multicenter, open-label, blinded end point, randomized controlled trial of alteplase dose and levels of BP control in thrombolyzed patients with AIS. Participants were randomly assigned to intensive (systolic target 130–140 mm Hg within 1 hour; maintained for 72 hours) or guideline-recommended (systolic target |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1161/strokeaha.124.049938 |
| DOI: |
10.1161/STROKEAHA.124.049938 |
| Availability: |
https://doi.org/10.1161/strokeaha.124.049938; https://www.ahajournals.org/doi/full/10.1161/STROKEAHA.124.049938 |
| Accession Number: |
edsbas.A320F26E |
| Database: |
BASE |