| Title: |
Trends in the incidence of young-adult-onset diabetes by diabetes type: a multi-national population-based study from an international diabetes consortium |
| Authors: |
Magliano, DJ; Chen, L; Morton, JI; Salim, A; Carstensen, B; Gregg, EW; Pavkov, ME; Arffman, M; Colhoun, HM; Ha, KH; Imamura, T; Jermendy, G; Kim, DJ; Kiss, Z; Mauricio, D; McGurnaghan, SJ; Nishioka, Y; Wild, SH; Winell, K; Shaw, JE |
| Contributors: |
110082; 105006; Ha, KH; Kim, DJ |
| Publication Year: |
2024 |
| Subject Terms: |
Adolescent; Adult; Age of Onset; Australia; Diabetes Mellitus; Type 1; Type 2; Female; Humans; Incidence; Male; Young Adult |
| Description: |
Background: Population-based incidence data on young-adult-onset type 1 diabetes and type 2 diabetes are limited. We aimed to examine secular trends in the incidence of diagnosed type 1 diabetes and type 2 diabetes with an age of onset between 15 and 39 years. Methods: In this multicountry aggregate data analysis, we assembled eight administrative datasets from high-income jurisdictions and countries (Australia, Denmark, Finland, Hungary, Japan, Scotland, South Korea, and Spain [Catalonia]) that had appropriate data available from an international diabetes consortium (GLOBODIAB) describing incidence by diabetes type among people aged 15–39 years from 2000 to 2020. We modelled type 1 diabetes and type 2 diabetes incidence rates using Poisson regression including age and calendar time by sex. Findings: During the years 2000–20, there were 349 591 incident diabetes (both types) cases from 346 million person-years of follow-up among people aged 15–39 years. Over time, there was no statistically significant change in the incidence of type 1 diabetes in Hungary and Japan. The incidence of type 1 diabetes significantly increased in Australia, Denmark, Finland, Scotland, South Korea, and Spain, with annual changes ranging from 0·5% to 6·0%. The incidence of type 2 diabetes significantly increased in four of eight jurisdictions (Denmark, Finland, Japan, and South Korea), with annual increases from 2·0% to 8·5%. The magnitude of increase in incidence of type 2 diabetes was greater in Asian than non-Asian jurisdictions. There was no statistically significant change in type 2 diabetes incidence in Australia and Hungary. The incidence of type 2 diabetes significantly decreased in Scotland and Spain, with annual changes of –0·7% and –1·5%, respectively. Interpretation: There is variability in the trajectory of the incidence of young-adult-onset type 2 diabetes among high-income countries or jurisdictions, with a greater evidence of increase in Asian than non-Asian countries. Evolving trends in the incidence of type 1 and type ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
J022138587; http://repository.ajou.ac.kr/handle/201003/33521 |
| DOI: |
10.1016/S2213-8587(24)00243-2 |
| Availability: |
http://repository.ajou.ac.kr/handle/201003/33521; https://doi.org/10.1016/S2213-8587(24)00243-2 |
| Accession Number: |
edsbas.A3237855 |
| Database: |
BASE |