| Title: |
Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder |
| Authors: |
Mertens, Jerome; Wang, Qiu-Wen; Kim, Yongsung; Yu, Diana X; Pham, Son; Yang, Bo; Zheng, Yi; Diffenderfer, Kenneth E; Zhang, Jian; Soltani, Sheila; Eames, Tameji; Schafer, Simon T; Boyer, Leah; Marchetto, Maria C; Nurnberger, John I; Calabrese, Joseph R; Oedegaard, Ketil J; McCarthy, Michael J; Zandi, Peter P; Alda, Martin; Nievergelt, Caroline M; Mi, Shuangli; Brennand, Kristen J; Kelsoe, John R; Gage, Fred H; Yao, Jun |
| Source: |
Nature, vol 527, iss 7576 |
| Publisher Information: |
eScholarship, University of California |
| Publication Year: |
2015 |
| Collection: |
University of California: eScholarship |
| Subject Terms: |
32 Biomedical and Clinical Sciences (for-2020); 3209 Neurosciences (for-2020); Stem Cell Research - Induced Pluripotent Stem Cell (rcdc); Mental Health (rcdc); Stem Cell Research - Induced Pluripotent Stem Cell - Human (rcdc); Brain Disorders (rcdc); Mental Illness (rcdc); Stem Cell Research (rcdc); Neurosciences (rcdc); Serious Mental Illness (rcdc); Bipolar Disorder (rcdc); Mental health (hrcs-hc); Action Potentials (mesh); Antipsychotic Agents (mesh); Bipolar Disorder (mesh); Calcium Signaling (mesh); Dentate Gyrus (mesh); Endophenotypes (mesh); Humans (mesh); Induced Pluripotent Stem Cells (mesh); Lithium Compounds (mesh); Male (mesh); Mitochondria (mesh); Neurons (mesh); Patch-Clamp Techniques (mesh); Pharmacogenomics of Bipolar Disorder Study |
| Subject Geographic: |
95 - 99 |
| Description: |
A neuronal model of bipolar disorder based on induced pluripotent stem cell (iPSC) technology finds hyperactive action-potential firing and differential responsiveness to lithium in iPSC-derived neurons from patients with bipolar disorder. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
qt3312q3zq; https://escholarship.org/uc/item/3312q3zq; https://escholarship.org/content/qt3312q3zq/qt3312q3zq.pdf |
| DOI: |
10.1038/nature15526 |
| Availability: |
https://escholarship.org/uc/item/3312q3zq; https://escholarship.org/content/qt3312q3zq/qt3312q3zq.pdf; https://doi.org/10.1038/nature15526 |
| Rights: |
public |
| Accession Number: |
edsbas.A384FEBA |
| Database: |
BASE |