| Title: |
Height, selected genetic markers and prostate cancer risk: results from the PRACTICAL consortium. |
| Authors: |
Lophatananon, Artitaya; Stewart-Brown, Sarah; Kote-Jarai, Zsofia; Olama, Ali Amin Al; Garcia, Sara Benlloch; Neal, David E; Hamdy, Freddie C; Donovan, Jenny L; Giles, Graham G; Fitzgerald, Liesel M; Southey, Melissa C; Pharoah, Paul; Pashayan, Nora; Gronberg, Henrik; Wiklund, Fredrik; Aly, Markus; Stanford, Janet L; Brenner, Hermann; Dieffenbach, Aida K; Arndt, Volker; Park, Jong Y; Lin, Hui-Yi; Sellers, Thomas; Slavov, Chavdar; Kaneva, Radka; Mitev, Vanio; Batra, Jyotsna; Spurdle, Amanda; Clements, Judith A; APCB BioResource; PRACTICAL consortium; Easton, Douglas; Eeles, Rosalind A; Muir, Kenneth |
| Publisher Information: |
Springer Nature; //doi.org/10.1038/bjc.2017.231 |
| Publication Year: |
2017 |
| Collection: |
Apollo - University of Cambridge Repository |
| Subject Terms: |
Aged; Body Height; Case-Control Studies; Gene-Environment Interaction; Humans; Male; Middle Aged; Neoplasm Grading; Polymorphism; Single Nucleotide; Prostatic Neoplasms; Risk Assessment |
| Description: |
BACKGROUND: Evidence on height and prostate cancer risk is mixed, however, recent studies with large data sets support a possible role for its association with the risk of aggressive prostate cancer. METHODS: We analysed data from the PRACTICAL consortium consisting of 6207 prostate cancer cases and 6016 controls and a subset of high grade cases (2480 cases). We explored height, polymorphisms in genes related to growth processes as main effects and their possible interactions. RESULTS: The results suggest that height is associated with high-grade prostate cancer risk. Men with height >180 cm are at a 22% increased risk as compared to men with height |
| Document Type: |
article in journal/newspaper |
| File Description: |
Print-Electronic; application/pdf |
| Language: |
English |
| Relation: |
https://www.repository.cam.ac.uk/handle/1810/270100 |
| DOI: |
10.17863/CAM.16913 |
| Availability: |
https://www.repository.cam.ac.uk/handle/1810/270100; https://doi.org/10.17863/CAM.16913 |
| Rights: |
Attribution 4.0 International ; https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.A387DCEB |
| Database: |
BASE |