| Title: |
Real-world Effectiveness and Safety of Tofacitinib in Multi-Refractory Ulcerative Colitis: insights from a Belgian Cohort with prior Anti-TNF and Vedolizumab Exposure |
| Authors: |
Cremer, A.; Mansour, A.; Lobaton, T.; Bossuyt, P.; Rahier, J.; Baert, F.; Dewit, O.; Macken, E.; Vijverman, A.; Van Hootegem, P.; Mana, F.; Willandt, B.; Humblet, E.; D'Heygere, F.; Verreth, A.; El Nawar, A.; COENEGRACHTS, Jean-Louis; Dewit, S.; De Coninck, S.; Schoofs, N.; Delen, S.; Dutre, J.; Thienpont, C.; Vanden Branden, S.; Staessen, D.; Croone, C.; Vieujean, S.; Franchimont, D. |
| Contributors: |
Cremer, A.; Mansour, A.; Lobaton, T.; Bossuyt, P.; Rahier, J.; Baert, F.; Dewit, O.; Macken, E.; Vijverman, A.; Van Hootegem, P.; Mana, F.; Willandt, B.; Humblet, E.; D'Heygere, F.; Verreth, A.; El Nawar, A.; COENEGRACHTS, Jean-Louis; Dewit, S.; De Coninck, S.; Schoofs, N.; Delen, S.; Dutre, J.; Thienpont, C.; Vanden Branden, S.; Staessen, D.; Croone, C.; Vieujean, S.; Franchimont, D. |
| Publisher Information: |
Vzw/asbl Acta Gastro-Enterologica Belgica |
| Publication Year: |
2025 |
| Collection: |
Document Server@UHasselt (Universiteit Hasselt) |
| Subject Terms: |
efficacy; inflammatory bowel disease; JAK inhibitor |
| Description: |
Background and aims: Tofacitinib has expanded treatment options for moderate-to-severe ulcerative colitis (UC). Longterm real-world data on its efficacy and safety remain limited, particularly in multi-refractory populations. This study evaluated the real-world effectiveness and safety of tofacitinib in Belgian UC patients with prior exposure to anti-TNF and vedolizumab. Patients and methods: This retrospective multicentric observational study included consecutive adult UC patients from 26 Belgian centers who initiated tofacitinib through an early access program (November 2018-August 2019). Data were prospectively collected. Primary endpoint was clinical remission (partial adapted Mayo score |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
https://hdl.handle.net/1942/47763; 237; 229; 88; 001604448600001 |
| DOI: |
10.51821/88.3.14064 |
| Availability: |
https://hdl.handle.net/1942/47763; https://doi.org/10.51821/88.3.14064 |
| Rights: |
Acta Gastro-Enterologica Belgica. Free access ; info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.A3BFB409 |
| Database: |
BASE |