| Title: |
Receptor‐binding Domain Severe Acute Respiratory Syndrome Coronavirus 2‐specific Antibodies in Human Milk From Mothers With Coronavirus Disease 2019 Polymerase Chain Reaction or With Symptoms Suggestive of Coronavirus Disease 2019 |
| Authors: |
Demers‐Mathieu, Veronique; DaPra, Ciera; Fels, Shawn; Medo, Elena |
| Source: |
Journal of Pediatric Gastroenterology and Nutrition ; volume 73, issue 1, page 125-128 ; ISSN 0277-2116 1536-4801 |
| Publisher Information: |
Wiley |
| Publication Year: |
2021 |
| Collection: |
Wiley Online Library (Open Access Articles via Crossref) |
| Description: |
This study aims to compare the receptor‐binding domain (RBD) severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)‐specific antibody titers in human milk between mothers with a confirmed coronavirus disease 2019 (COVID‐19) polymerase chain reaction (PCR) test and mothers with viral symptoms suggestive of COVID‐19. The area under the curve (AUC) for RBD SARS‐CoV‐2‐specific secretory immunoglobulin A (SIgA)/immunoglobulin A (IgA), secretory immunoglobulin M (SIgM)/immunoglobulin M (IgM), immunoglobulin G (IgG), and free secretory components (fSC) in milk samples from eight mothers with a confirmed COVID‐19 PCR, eight mothers with viral symptoms (no PCR testing), and six unexposed mothers (pre‐pandemic 2018). AUCs of RBD SARS‐CoV‐2‐specific SIgA/IgA, SIgM/IgM, IgG, and fSC in milk samples were comparable between mothers with confirmed COVID‐19 PCR and mothers with viral symptoms of suggestive COVID‐19. AUCs of RBD‐specific SIgA/IgA, IgG, and fSC were higher in the COVID‐19‐exposed group than in the unexposed group, and SIgM/IgM tended to be higher in the exposed mothers. In conclusion, women with viral symptoms suggestive of COVID‐19 could secrete antibodies and fSC specific to SARS‐CoV‐2 in human milk. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1097/mpg.0000000000003158 |
| DOI: |
10.1097/MPG.0000000000003158 |
| Availability: |
https://doi.org/10.1097/mpg.0000000000003158; https://onlinelibrary.wiley.com/doi/pdf/10.1097/MPG.0000000000003158 |
| Rights: |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
| Accession Number: |
edsbas.A3DAF8B5 |
| Database: |
BASE |