| Title: |
A Hopeful Leap Forward by Multicentric Cooperation for Precision-Based Therapy for Very Resistant, Relapsed, or Refractory Childhood Leukemia |
| Authors: |
Bornhauser, Beat C; Bourquin, Jean-Pierre |
| Source: |
Bornhauser, Beat C; Bourquin, Jean-Pierre (2021). A Hopeful Leap Forward by Multicentric Cooperation for Precision-Based Therapy for Very Resistant, Relapsed, or Refractory Childhood Leukemia. Cancer Discovery, 11(6):1322-1323. |
| Publisher Information: |
American Association for Cancer Research |
| Publication Year: |
2021 |
| Collection: |
University of Zurich (UZH): ZORA (Zurich Open Repository and Archive |
| Subject Terms: |
Medical Clinic; 610 Medicine & health |
| Description: |
Pikman and colleagues report the results of a multicentric prospective clinical trial of the leukemia precision-based therapy (LEAP) consortium that combines identification of targetable lesions in drug-resistant childhood leukemia, tiered based on evidence for genomic lesions and drug target, validation of matching small-molecule targeted agents, and treatment of individual patients. The study demonstrates the impact of genomic information on disease classification, treatment guidance, and translational research, but also illustrates the challenges for target prediction and trial design for increasingly heterogeneous and smaller subgroups of patients.See related article by Pikman et al., p. 1424. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| ISSN: |
2159-8274 |
| Relation: |
https://www.zora.uzh.ch/id/eprint/213016/1/caner_discovery.pdf; info:pmid/34078660; urn:issn:2159-8274 |
| Availability: |
https://www.zora.uzh.ch/id/eprint/213016/; https://www.zora.uzh.ch/id/eprint/213016/1/caner_discovery.pdf |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.A3E0D490 |
| Database: |
BASE |