| Title: |
Equine trypanosomiasis, a systematic review: disease management |
| Authors: |
Raftery, Alexandra G.; Gummery, Lauren; Garcia, Karelhia; Mohite, Dinesh; Capewell, Paul; Sutton, David |
| Publisher Information: |
Wiley |
| Publication Year: |
2026 |
| Collection: |
University of Glasgow: Enlighten - Publications |
| Description: |
Background: Equine trypanosomiasis is a neglected protozoal disease. Objectives: To answer the study question: In equines what are the effects of disease management of trypanosomiasis on disease severity (individual level) and disease prevalence (population level) compared to no intervention? Study Design: Systematic review. Methods: Studies were identified that described management of naturally occurring equine trypanosomiasis in any country following ‘Preferred Reporting Items for Systematic Reviews and Meta-analyses’ using eight international databases (1980–2022). Risk of bias was assessed using ROBINS-I. Data synthesis was descriptive. Results: Thirty studies were included (9 case reports, 5 case series, 15 cohorts, 1 randomised non-inferiority trial). Risk of bias was ‘serious’ (22/30), ‘moderate’ (7/30), ‘low’ (1/30). Heterogeneity was high. Disease severity (individual): Trypanosoma evansi: all evaluated trypanocides were effective in blood parasitaemia clearance (weak evidence). Clinical relapses were common (n = 60/241 equines treated; 25%) (strong evidence). Efficacy was poor once neurological signs were present (n = 12/19 equines; 63% mortality) (strong evidence). Trypanosoma equiperdum: a combination protocol could be curative before CNS invasion (weak evidence). Tsetse transmitted trypanosomiasis: Treatment of haemolymphatic disease with isometamidium or diminazene resulted in a positive clinical response (strong evidence). New/recrudescing infections were common in some regions (strong evidence). Trypanosoma vivax: treatment with high-dose diminazene had a poor clinical outcome (weak evidence). Disease prevalence (population): a multifaceted control programme was effective in reducing disease prevalence (weak evidence). Early ( |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| Relation: |
https://eprints.gla.ac.uk/372947/2/372947.pdf; Raftery, Alexandra G. ORCID logoorcid:0000-0003-4365-7654 , Gummery, Lauren , Garcia, Karelhia, Mohite, Dinesh, Capewell, Paul and Sutton, David ORCID logoorcid:0000-0002-7241-8444 (2026) Equine trypanosomiasis, a systematic review: disease management. Equine Veterinary Journal , 58(2), pp. 320-332. (doi:10.1002/evj.70136 ) (PMID:41429593) (PMCID:PMC12892392) |
| DOI: |
10.1002/evj.70136 |
| Availability: |
https://eprints.gla.ac.uk/372947/; https://eprints.gla.ac.uk/372947/2/372947.pdf; https://doi.org/10.1002/evj.70136 |
| Rights: |
cc_by_4 |
| Accession Number: |
edsbas.A45896C7 |
| Database: |
BASE |