| Title: |
Long-Term Ozone Exposure and Small Airway Dysfunction: The China Pulmonary Health (CPH) Study |
| Authors: |
Niu, Yue; Yang, Ting; Gu, Xiaoying; Chen, Renjie; Meng, Xia; Xu, Jianying; Yang, Lan; Zhao, Jianping; Zhang, Xiangyan; Bai, Chunxue; Kang, Jian; Ran, Pixin; Shen, Huahao; Wen, Fuqiang; Huang, Kewu; Chen, Yahong; Sun, Tieying; Shan, Guangliang; Lin, Yingxiang; Wu, Sinan; Zhu, Jianguo; Wang, Ruiying; Shi, Zhihong; Xu, Yongjian; Ye, Xianwei; Song, Yuanlin; Wang, Qiuyue; Zhou, Yumin; Ding, Liren; Yao, Wanzhen; Guo, Yanfei; Xiao, Fei; Lu, Yong; Peng, Xiaoxia; Zhang, Biao; Xiao, Dan; Wang, Zuomin; Zhang, Hong; Bu, Xiaoning; Zhang, Xiaolei; An, Li; Zhang, Shu; Cao, Zhixin; Zhan, Qingyuan; Yang, Yuanhua; Liang, Lirong; Cao, Bin; Dai, Huaping; Wu, Tangchun |
| Source: |
American Journal of Respiratory and Critical Care Medicine ; volume 205, issue 4, page 450-458 ; ISSN 1073-449X 1535-4970 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2022 |
| Description: |
Rationale It remains unknown whether long-term ozone exposure can impair lung function. Objectives To investigate the associations between long-term ozone exposure and adult lung function in China. Methods Lung function results and diagnosis of small airway dysfunction (SAD) were collected from a cross-sectional study, the China Pulmonary Health Study (N = 50,991). We used multivariable linear and logistic regression models to examine the associations of long-term ozone exposure with lung function parameters and SAD, respectively, adjusting for demographic characteristics, individual risk factors, and longitudinal trends. We then performed a stratification analysis by chronic obstructive pulmonary disease (COPD). Measurements and Main Results We observed that each 1 SD (4.9 ppb) increase in warm-season ozone concentrations was associated with a 14.2 ml/s (95% confidence interval [CI], 8.8–19.6 ml/s] decrease in forced expiratory flow at the 75th percentile of vital capacity and a 29.5 ml/s (95% CI, 19.6–39.5 ml/s) decrease in mean forced expiratory flow between the 25th and 75th percentile of vital capacity. The odds ratio of SAD was 1.09 (95% CI, 1.06–1.11) for a 1 SD increase in warm-season ozone concentrations. Meanwhile, we observed a significant association with decreased FEV1/FVC but not with FEV1 or FVC. The association estimates were greater in the COPD group than in the non-COPD group. Conclusions We found independent associations of long-term ozone exposure with impaired small airway function and higher SAD risks, while the associations with airflow obstruction were weak. Patients with COPD appear to be more vulnerable. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1164/rccm.202107-1599oc |
| Availability: |
https://doi.org/10.1164/rccm.202107-1599oc; https://academic.oup.com/ajrccm/article-pdf/205/4/450/67008583/ajrccm_205_4_450.pdf |
| Rights: |
https://academic.oup.com/pages/standard-publication-reuse-rights |
| Accession Number: |
edsbas.A49E31C0 |
| Database: |
BASE |