| Title: |
Modulation of the Innate Immune Response by Targeting Toll-like Receptors: A Perspective on Their Agonists and Antagonists |
| Authors: |
Federico S.; Pozzetti L.; Papa A.; Carullo G.; Gemma S.; Butini S.; Campiani G.; Relitti N. |
| Contributors: |
Federico, S.; Pozzetti, L.; Papa, A.; Carullo, G.; Gemma, S.; Butini, S.; Campiani, G.; Relitti, N. |
| Publication Year: |
2020 |
| Collection: |
Università degli Studi di Siena: USiena air |
| Subject Terms: |
Animal; Antineoplastic Agent; Communicable Disease; Drug Delivery System; Human; Hypoglycemic Agent; Immunity; Innate; Metabolic Disease; Neoplasm; Protein Structure; Secondary; Toll-Like Receptors |
| Description: |
Toll-like receptors (TLRs) are a class of proteins that recognize pathogen-associated molecular patterns (PAMPs) and damaged-associated molecular patterns (DAMPs), and they are involved in the regulation of innate immune system. These transmembrane receptors, localized at the cellular or endosomal membrane, trigger inflammatory processes through either myeloid differentiation primary response 88 (MyD88) or TIR-domain-containing adapter-inducing interferon-β (TRIF) signaling pathways. In the last decades, extensive research has been performed on TLR modulators and their therapeutic implication under several pathological conditions, spanning from infections to cancer, from metabolic disorders to neurodegeneration and autoimmune diseases. This Perspective will highlight the recent discoveries in this field, emphasizing the role of TLRs in different diseases and the therapeutic effect of their natural and synthetic modulators, and it will discuss insights for the future exploitation of TLR modulators in human health. © 2020 American Chemical Society. |
| Document Type: |
article in journal/newspaper |
| File Description: |
STAMPA |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/32845153; info:eu-repo/semantics/altIdentifier/wos/WOS:000595545900015; volume:63; issue:22; firstpage:13466; lastpage:13513; numberofpages:48; journal:JOURNAL OF MEDICINAL CHEMISTRY; http://hdl.handle.net/11365/1126076 |
| DOI: |
10.1021/acs.jmedchem.0c01049 |
| Availability: |
http://hdl.handle.net/11365/1126076; https://doi.org/10.1021/acs.jmedchem.0c01049; https://pubs.acs.org/doi/10.1021/acs.jmedchem.0c01049 |
| Rights: |
info:eu-repo/semantics/closedAccess |
| Accession Number: |
edsbas.A4CD1DF2 |
| Database: |
BASE |