| Title: |
In vivo biocompatibility of a new hydrophobic coated Al/Al2O3 nanowire surface on stents |
| Authors: |
Rentzsch, Axel; Metz, Eva; Mühl-Benninghaus, Ruben; Maßmann, Alexander; Bettink, Stephanie; Scheller, Bruno; Lemke, Lilia; Awadelkareem, Ali; Tomori, Toshiki; Haidar, Ayman; Laschke, Matthias W.; Menger, Michael D.; Aktas, Cenk; Hannig, Matthias; Pütz, Norbert; Büttner, Thomas; Scheschkewitz, David; Veith, Michael; Abdul-Khaliq, Hashim |
| Publisher Information: |
Saarländische Universitäts- und Landesbibliothek |
| Publication Year: |
2024 |
| Collection: |
SciDok - Der Wissenschaftsserver der UdS (Universität des Saarlandes) |
| Subject Terms: |
ddc:500; ddc:610; In-stent restenosis; Bare metal stent; Innovation; Optical coherence tomography |
| Description: |
Background: Intima proliferation and in-stent restenosis is a challenging situation in interventional treatment of small vessel obstruction. Al/Al2O3 nanowires have been shown to accelerate vascular endothelial cell proliferation and mi gration in vitro, while suppressing vascular smooth muscle cell growth. Moreover, surface modification of Al/Al2O3 nanowires with poly[bis(2,2,2-trifluoromethoxy)phosphazene (PTFEP) coating enables further advantages such as re duced platelet adhesion. Therefore, the study's goal was to compare the biocompatibility of novel Al/Al2O3 + PTFEP coated nanowire bare-metal stents to uncoated control stents in vivo using optical coherence tomography (OCT), quan titative angiography and histomorphometric assessment. Methods: 15 Al/Al2O3 + PTFEP coated and 19 control stents were implanted in the cervical arteries of 9 Aachen minipigs. After 90 days, in-stent stenosis, thrombogenicity, and inflammatory response were assessed. Scanning elec tron microscopy was used to analyse the stent surface. Results: OCT analysis revealed that neointimal proliferation in Al/Al2O3 + PTFEP coated stents was significantly re duced compared to control stents. The neointimal area was 1.16 ± 0.77 mm2 in Al/Al2O3 + PTFEP coated stents vs. 1.98 ± 1.04 mm2 in control stents (p = 0.004), and the neointimal thickness was 0.28 ± 0.20 vs. 0.47 ± 0.10 (p = 0.003). Quantitative angiography showed a tendency to less neointimal growth in coated stents. Histomorphometry showed no significant difference between the two groups and revealed an apparent inflammatory reaction surrounding the stent struts. Conclusions: At long-term follow-up, Al/Al2O3 + PTFEP coated stents placed in peripheral arteries demonstrated good tolerance with no treatment-associated vascular obstruction and reduced in-stent restenosis in OCT. These preliminary in vivo findings indicate that Al/Al2O3 + PTFEP coated nanowire stents may have translational potential to be used for the prevention of in-stent restenosis. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://ars.els-cdn.com/content/image/1-s2.0-S1553838924006390-mmc1.docx; hdl:20.500.11880/40232 |
| DOI: |
10.22028/D291-45786 |
| DOI: |
10.1016/j.carrev.2024.08.017 |
| Availability: |
http://nbn-resolving.org/urn:nbn:de:bsz:291--ds-457864; https://doi.org/10.22028/D291-45786; https://doi.org/10.1016/j.carrev.2024.08.017 |
| Rights: |
openAccess ; Alle Ressourcen in diesem Repository sind urheberrechtlich geschützt ; https://creativecommons.org/licenses/by/4.0/ ; Attribution 4.0 International CC BY 4.0 Deed |
| Accession Number: |
edsbas.A4D2A02B |
| Database: |
BASE |