| Title: |
Low-density lipoprotein cholesterol levels and risk of incident dementia: a distributed network analysis using common data models |
| Authors: |
Lee, M; Lee, KJ; Kim, J; Lee, DY; Park, RW; Rhee, SY; Cha, JM; Yang, HJ; Jang, JW; Jung, S; Lee, J; Lee, SH; Kim, C; Bae, JS; Kim, YJ; Lee, JH; Bae, H; Kim, Y |
| Contributors: |
2; 101884; Park, RW |
| Publication Year: |
2025 |
| Subject Terms: |
Aged; 80 and over; Alzheimer Disease; Cholesterol; LDL; Dementia; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Incidence; Male; Propensity Score; Retrospective Studies; Risk Factors |
| Description: |
BACKGROUND: The link between low-density lipoprotein cholesterol (LDL-C) levels and dementia risk is poorly understood, with conflicting evidence on the role of LDL-C and the impact of statin therapy on cognitive outcomes. Thus, we aimed to examine the association between low-density LDL-C levels and the risk of dementia and assess the influence of statin therapy. METHODS: We retrospectively analysed data from 11 university hospitals participating in the Observational Medical Outcomes Partnership (OMOP) Common Data Model (CDM). Participants with a prior diagnosis of dementia or those with |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
J000223050; http://repository.ajou.ac.kr/handle/201003/34598 |
| DOI: |
10.1136/jnnp-2024-334708 |
| Availability: |
http://repository.ajou.ac.kr/handle/201003/34598; https://doi.org/10.1136/jnnp-2024-334708 |
| Accession Number: |
edsbas.A4DC2183 |
| Database: |
BASE |