| Title: |
Convergent transcriptomic and connectomic controllers of information integration and its anaesthetic breakdown across mammalian brains |
| Authors: |
Luppi, AI; Uhrig, L; Tasserie, J; Mediano, PAM; Rosas, FE; Singleton, SP; Gutierrez-Barragan, D; Gini, S; Castro, P; Signorelli, CM; Golkowski, D; Ranft, A; Ilg, R; Jordan, D; Muta, K; Hata, J; Okano, H; Liu, Z-Q; Yee, Y; Destexhe, A; Cofre, R; Menon, DK; Gozzi, A; Jarraya, B; Stamatakis, EA |
| Publisher Information: |
Nature Research |
| Publication Year: |
2025 |
| Collection: |
Oxford University Research Archive (ORA) |
| Description: |
The mammalian brain orchestrates the processing and integration of information to guide behaviour. Here, to characterize mammalian information-processing architecture, we combine functional neuroimaging and anaesthesia in humans, macaques, marmosets and mice. We show that breakdown of information integration is a convergent effect of diverse anaesthetics across mammalian species. As the system disintegrates, brain dynamics become more difficult to control. Both effects are reversed upon re-awakening induced by thalamic deep-brain stimulation in the macaque. Regional breakdown of integrated information coincides with the species-specific spatial topography of PVALB/Pvalb gene expression. To provide mechanistic insight beyond correlation, we develop computational models for humans, macaques and mice that integrate species-specific connectivity and transcriptomic gradients, demonstrating their respective roles for controlling brain dynamics and information integration. We reveal evolutionarily conserved controllers of information integration in the mammalian brain. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1038/s41562-025-02381-5 |
| Availability: |
https://doi.org/10.1038/s41562-025-02381-5; https://ora.ox.ac.uk/objects/uuid:497d3bd2-6af6-4074-957d-9d04c15dfc64 |
| Rights: |
info:eu-repo/semantics/openAccess ; CC Attribution (CC BY) |
| Accession Number: |
edsbas.A5097B4D |
| Database: |
BASE |