| Title: |
Fifteen millennia of human mitogenome evolution in Sicily |
| Authors: |
Tommasi, Anna; Boscolo Agostini, Rajiv; Villani, Giacomo; Rambaldi Migliore, Nicola; Vizzari, Maria T.; Cardinali, Irene; Di Gerlando, Rosalinda; Nicolini, Valeria; Sorasio, Gary; Santos, Patrícia; Olivieri, Anna; Perego, Ugo A.; Catalano, Giulio; Volante, Nicoletta; Sarti, Lucia; Caramelli, David; Sineo, Luca; Lancioni, Hovirag; Modi, Alessandra; Ghirotto, Silvia; Achilli, Alessandro |
| Contributors: |
Tommasi, Anna; Boscolo Agostini, Rajiv; Villani, Giacomo; Rambaldi Migliore, Nicola; Vizzari, Maria T.; Cardinali, Irene; Di Gerlando, Rosalinda; Nicolini, Valeria; Sorasio, Gary; Santos, Patrícia; Olivieri, Anna; Perego, Ugo A.; Catalano, Giulio; Volante, Nicoletta; Sarti, Lucia; Caramelli, David; Sineo, Luca; Lancioni, Hovirag; Modi, Alessandra; Ghirotto, Silvia; Achilli, Alessandro |
| Publication Year: |
2025 |
| Collection: |
Università degli Studi di Ferrara: CINECA IRIS |
| Description: |
Sicily, situated at the heart of the Mediterranean Sea, has been a crossroads of people of different origins since the Paleolithic. To gain further insight into the genetic history of this island from a matrilineal viewpoint, we investigated 15 millennia of human mitogenome evolution. A unique Sicilian mitochondrial DNA (mtDNA) dataset, represented by 116 ancient mitogenomes (including two newly sequenced) collected from 16 archeological sites dating from 14,700 to 545 years ago, was compared with a collection of 236 modern mitogenomes covering all districts of the island. By integrating demographic modeling with phylogeographic analyses, we identified a statistically supported genetic discontinuity between the Paleolithic/Late Mesolithic and Early Neolithic periods and two mtDNA lineages (U5b and U8b/K) that specifically mark this transition. The extensive variation and lack of genetic structure among modern mitogenomes suggest the presence of a continuous, maternally inherited gene flow from different regions of Western Eurasia (since the Paleolithic) and Africa (since the Bronze Age). |
| Document Type: |
article in journal/newspaper |
| File Description: |
STAMPA |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/41237225; info:eu-repo/semantics/altIdentifier/wos/WOS:001616251900007; volume:11; issue:46; firstpage:eady1674-1; lastpage:eady1674-13; numberofpages:13; journal:SCIENCE ADVANCES; https://hdl.handle.net/11392/2611670 |
| DOI: |
10.1126/sciadv.ady1674 |
| Availability: |
https://hdl.handle.net/11392/2611670; https://doi.org/10.1126/sciadv.ady1674; https://www.science.org/doi/10.1126/sciadv.ady1674 |
| Rights: |
info:eu-repo/semantics/openAccess ; license:Creative commons ; license uri:http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.A5445292 |
| Database: |
BASE |