| Title: |
Automated collateral assessment restricted to the hypoperfused area for distal vessel occlusions in ischemic stroke |
| Authors: |
de Vries,Lucas; Robbe,M. M.Quirien; Jansen,Ivo G.H.; Mojtahedi,S. Mahsa; Hoving,Jan W.; Olthuis,Susanne G.H.; Knapen,Robrecht R.M.M.; Pinckaers,Florentina M.E.; Kappelhof,Manon; Beenen,Ludo F.M.; Postma,Alida A.; van Oostenbrugge,Robert J.; Dippel,Diederik W.J.; Gavves,Efstratios; Emmer,Bart J.; Majoie,Charles B.L.M.; van Zwam,Wim H.; Marquering,Henk A.; Pinckaers,Floor; Deniz,Rabia; van der Ende,Nadinda A.M.; Bruggeman,Agnetha A.E.; Pirson,Anne F.A.V.; Boodt,Nikki; Ramos,Lucas A.; Arrarte-Terreros,Nerea; Prasetya,Haryadi; Konduri,Praneeta R.; LeCouffe,Natalie E.; Groot,Adrien E.D.; Collette,Sabine L.; Schupp,Lieve M.; Voogd,Eva J.H.F.; Kirkels,Eleonora L.F.; Groot,P. F.C.; de Jong,Anouk; Simons,Michelle; Bakker,Jeanette; Pegge,Sjoert; Lo, Rob H.; van Doormaal,Pieter Jan; Bokkers,Reinoud P.H.; de Vries,J.; van Dijk,Ewoud J.; van der Worp, H. Bart; van den Heuvel,Lotte; Hinsenveld,Wouter H.; Goldhoorn,Robert Jan B.; Adverse event committee; Writing committee; Imaging assessment committee; Local principal investigators; Study coordinators; Executive committee; on behalf of the MR CLEAN Registry Investigators; Clinical/imaging data acquisition; Research nurses / local trial coordinators; Trial methodologist; Researchgr. Systems Radiology; MS Radiologie; Circulatory Health; Brain; Neurologen; Stroke |
| Publication Year: |
2025 |
| Subject Terms: |
Brain; Collateral circulation; Computed tomography angiography; Perfusion imaging; Stroke; Radiology Nuclear Medicine and imaging |
| Description: |
Objectives: This study aims to: (1) develop and evaluate a quantitative assessment of collateral status in the downstream area of an occluded intracranial artery in acute ischemic stroke and compare this method to middle cerebral artery (MCA)-based assessment; (2) determine the agreement between the automated occlusion-downstream area collateral score (ODACS) and expert raters’ assessments, and compare this to inter-rater agreement. Methods: Patients from MR CLEAN-NO IV and MR CLEAN Registry with a proximal M1, distal M1, or M2 occlusion were included. Using the hypoperfused area from CT perfusion (CTP) as a proxy for the occlusion-downstream territory and automated vessel segmentations from CT angiography (CTA), ODACS is calculated as the vessel volume ratio between downstream ipsilateral and its contralateral regions. ODACS was compared to a whole MCA-territory approach and evaluated against visual scoring by two expert raters that visually estimated ODACS using CTA and CTP, and their inter-rater agreement. Results: The study included 204 patients with a proximal M1 (52%), distal M1 (32%), or M2 (16%) occlusion. ODACS yielded lower collateral scores than MCA-based scoring for all occlusion locations, with larger differences in more distal occlusions. For M2 occlusions, 58% of patients shifted from good (> 50%) to poor (≤ 50%) collateral filling of the occluded territory using ODACS. Moderate (weighted Cohen’s kappa κ = 0.45) inter-rater agreement and fair (κ = 0.35) to moderate (κ = 0.51) ODACS-rater agreement were observed. Conclusions: ODACS yields lower collateral scores compared to MCA-based scoring and is comparable to scores from expert raters. Key Points: Question CT angiography-based collateral assessment in the MCA territory is inadequate to assess the collateral status in patients with distal vessel occlusions. Findings Our automated ODACS revealed lower collateral scores than traditional whole-territory assessment, especially in distal vessel occlusions. Clinical relevance The more precise ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| ISSN: |
0938-7994 |
| Relation: |
https://dspace.library.uu.nl/handle/1874/467246 |
| Availability: |
https://dspace.library.uu.nl/handle/1874/467246 |
| Rights: |
info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.A5551524 |
| Database: |
BASE |