| Title: |
Sr internal exposure outcomes on oxydative stress and senescence in bone and bone marrow ; Effets de l'exposition interne au 90Sr sur le stress oxydant et l'induction de senescence dans le tissus osseux et la moelle osseuse. |
| Authors: |
Musilli, Stefania; Grand, Céline; Culeux, Cécile; Cochard, Margaux; Tack, Karine; Kerdine-Römer, Saadia; Bertho, Jean-Marc |
| Contributors: |
Laboratoire de radiotoxicologie et radiobiologie expérimentale (IRSN/PSE-SANTE/SESANE/LRTOX); Service de recherche sur les effets biologiques et Sanitaires des rayonnements ionisants (IRSN/PSE-SANTE/SESANE); Institut de Radioprotection et de Sûreté Nucléaire (IRSN)-Institut de Radioprotection et de Sûreté Nucléaire (IRSN); Inflammation, microbiome, immunosurveillance (MI2); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay; Institut de Radioprotection et de Sûreté Nucléaire - IRSN; GTR IRSN - Santé Environnement (D3P16) |
| Source: |
https://asnr.hal.science/hal-05279343 ; 2025. |
| Publisher Information: |
CCSD |
| Publication Year: |
2025 |
| Subject Terms: |
Internal contamination; 90 Sr; Bone; Bone marrow; Senescence; Oxidative stress; [SDV]Life Sciences [q-bio]; [SDV.TOX]Life Sciences [q-bio]/Toxicology |
| Description: |
After nuclear disasters, large amounts of radionuclides can be released into the environment. Strontium 90 ( 90 Sr) is a bone-seeking element and is part of these persistent radionuclides in the environment. Our previous studies in mice demonstrated that the chronic ingestion of 90 Sr at low doses leads to a decreased immune response and a modification of the bone physiology. Moreover, using an in vitro assay we showed that such an effect could be explained by the induction of the senescence in the mesenchymal stem cells that support the hematopoietic differentiation. In the present study, to better understand the effects of 90 Sr on both immune system and bone physiology, the expression of genes and the levels of proteins involved in bone and bone marrow homeostasis were measured in Balb/c mice exposed to 90 Sr during fetal life until the age of 24 weeks. The parent mice and offspring were exposed chronically via drinking water containing 90 Sr at 4, 20 or 100 kBq.L -1 . Results indicated a decrease in gene expression of bone formation markers and an increase in antioxydative enzymes. In addition, an increase in p21 expression, a potential marker of senescence, and a decrease in IL-6 were also observed in bone of contaminated mice. |
| Document Type: |
report |
| Language: |
English |
| Availability: |
https://asnr.hal.science/hal-05279343; https://asnr.hal.science/hal-05279343v1/document; https://asnr.hal.science/hal-05279343v1/file/Musilli-MS38-VF-HAL.pdf |
| Rights: |
https://creativecommons.org/licenses/by-nc/4.0/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.A56B64E5 |
| Database: |
BASE |