| Title: |
Autoantibodies against type I IFNs in patients with life-threatening COVID-19 |
| Authors: |
Bastard, Paul; Rosen, Lindsey B.; Zhang, Qian; Michailidis, Eleftherios; Hoffmann, Hans-Heinrich; Zhang, Yu; Dorgham, Karim; Philippot, Quentin; Rosain, Jérémie; Béziat, Vivien; Manry, Jérémy; Shaw, Elana; Haljasmägi, Liis; Peterson, Pärt; Lorenzo, Lazaro; Bizien, Lucy; Trouillet-Assant, Sophie; Dobbs, Kerry; de Jesus, Adriana Almeida; Belot, Alexandre; Kallaste, Anne; Catherinot, Emilie; Tandjaoui-Lambiotte, Yacine; Le Pen, Jeremie; Kerner, Gaspard; Bigio, Benedetta; Seeleuthner, Yoann; Yang, Rui; Bolze, Alexandre; Spaan, András N.; Delmonte, Ottavia M.; Abers, Michael S.; Aiuti, Alessandro; Casari, Giorgio; Lampasona, Vito; Piemonti, Lorenzo; Ciceri, Fabio; Bilguvar, Kaya; Lifton, Richard P.; Vasse, Marc; Smadja, David M.; Migaud, Mélanie; Hadjadj, Jérome; Terrier, Benjamin; Duffy, Darragh; Quintana-Murci, Lluis; van de Beek, Diederik; Roussel, Lucie; Vinh, Donald C.; Tangye, Stuart G.; Haerynck, Filomeen; Dalmau, David; Martinez-Picado, Javier; Brodin, Petter; Nussenzweig, Michel C.; Boisson-Dupuis, Stéphanie; Rodríguez-Gallego, Carlos; Vogt, Guillaume; Mogensen, Trine H.; Oler, Andrew J.; Gu, Jingwen; Burbelo, Peter D.; Cohen, Jeffrey I.; Biondi, Andrea; Bettini, Laura Rachele; D'Angio, Mariella; Bonfanti, Paolo; Rossignol, Patrick; Mayaux, Julien; Rieux-Laucat, Frédéric; Husebye, Eystein S.; Fusco, Francesca; Ursini, Matilde Valeria; Imberti, Luisa; Sottini, Alessandra; Paghera, Simone; Quiros-Roldan, Eugenia; Rossi, Camillo; Castagnoli, Riccardo; Montagna, Daniela; Licari, Amelia; Marseglia, Gian Luigi; Duval, Xavier; Ghosn, Jade; Tsang, John S.; Goldbach-Mansky, Raphaela; Kisand, Kai; Lionakis, Michail S.; Puel, Anne; Zhang, Shen-Ying; Holland, Steven M.; Gorochov, Guy; Jouanguy, Emmanuelle; Rice, Charles M.; Cobat, Aurélie; Notarangelo, Luigi D.; Abel, Laurent; Su, Helen C.; Casanova, Jean-Laurent; Arias, Andrés Augusto; Boisson, Bertrand; Boucherit, Soraya; Bustamante, Jacinta; Chbihi, Marwa; Chen, Jie; Chrabieh, Maya; Kochetkov, Tatiana; Le Voyer, Tom; Liu, Dana; Nemirovskaya, Yelena; Ogishi, Masato; Papandrea, Dominick; Patissier, Cécile; Rapaport, Franck; Roynard, Manon; Vladikine, Natasha; Woollett, Mark; Zhang, Peng; Kashyap, Anuj; Ding, Li; Bosticardo, Marita; Wang, Qinlu; Ochoa, Sebastian; Liu, Hui; Chauvin, Samuel D.; Stack, Michael; Koroleva, Galina; Bansal, Neha; Dalgard, Clifton L.; Snow, Andrew L.; Abad, Jorge; Aguilera-Albesa, Sergio; Akcan, Ozge Metin; Darazam, Ilad Alavi; Aldave, Juan C.; Ramos, Miquel Alfonso; Nadji, Seyed Alireza; Alkan, Gulsum; Allardet-Servent, Jerome; Allende, Luis M.; Alsina, Laia; Alyanakian, Marie-Alexandra; Amador-Borrero, Blanca; Amoura, Zahir; Antolí, Arnau; Arslan, Sevket; Assant, Sophie; Auguet, Terese; Azot, Axelle; Bajolle, Fanny; Baldolli, Aurélie; Ballester, Maite; Feldman, Hagit Baris; Barrou, Benoit; Beurton, Alexandra; Bilbao, Agurtzane; Blanchard-Rohner, Geraldine; Blanco, Ignacio; Blandinières, Adeline; Blazquez-Gamero, Daniel; Bloomfield, Marketa; Bolivar-Prados, Mireia; Borie, Raphael; Bousfiha, Ahmed A.; Bouvattier, Claire; Boyarchuk, Oksana; Bueno, Maria Rita P.; Cáceres Agra, Juan José; Calimli, Semra; Capra, Ruggero; Carrabba, Maria; Casasnovas, Carlos; Caseris, Marion; Castelle, Martin; Castelli, Francesco; de Vera, Martín Castillo; Castro, Mateus V.; Chalumeau, Martin; Charbit, Bruno; Cheng, Matthew P.; Clavé, Père; Clotet, Bonaventura; Codina, Anna; Colkesen, Fatih; Colkesen, Fatma; Colobran, Roger; Comarmond, Cloé; Corsico, Angelo G.; Darley, David Ross; Dauby, Nicolas; Dauger, Stéphane; de Pontual, Loic; Dehban, Amin; Delplancq, Geoffroy; Demoule, Alexandre; Di Sabatino, Antonio; Diehl, Jean-Luc; Dobbelaere, Stephanie; Durand, Sophie; Eldars, Waleed; Elgamal, Mohamed; Elnagdy, Marwa H.; Emiroglu, Melike; Erdeniz, Emine Hafize; Aytekin, Selma Erol; Euvrard, Romain; Evcen, Recep; Fabio, Giovanna; Faivre, Laurence; Falck, Antonin; Fartoukh, Muriel; Faure, Morgane; Arquero, Miguel Fernandez; Flores, Carlos; Francois, Bruno; Fumadó, Victoria; Solis, Blanca Garcia; Gaussem, Pascale; Gil-Herrera, Juana; Gilardin, Laurent; Alarcon, Monica Girona; Girona-Alarcón, Mónica; Goffard, Jean-Christophe; Gok, Funda; González-Montelongo, Rafaela; Guerder, Antoine; Gul, Yahya; Guner, Sukru Nail; Gut, Marta; Hadjadj, Jérôme; Halwani, Rabih; Hammarström, Lennart; Hatipoglu, Nevin; Hernandez-Brito, Elisa; Holanda-Peña, María Soledad; Horcajada, Juan Pablo; Hraiech, Sami; Humbert, Linda; Iglesias, Alejandro D.; Íñigo-Campos, Antonio; Jamme, Matthieu; Arranz, María Jesús; Jordan, Iolanda; Kanat, Fikret; Kapakli, Hasan; Kara, Iskender; Karbuz, Adem; Yasar, Kadriye Kart; Keles, Sevgi; Demirkol, Yasemin Kendir; Klocperk, Adam; Król, Zbigniew J.; Kuentz, Paul; Kwan, Yat Wah M.; Lagier, Jean-Christophe; Lau, Yu-Lung; Le Bourgeois, Fleur; Leo, Yee-Sin; Lopez, Rafael Leon; Leung, Daniel; Levin, Michael; Levy, Michael; Lévy, Romain; Li, Zhi; Linglart, Agnes; Lorenzo-Salazar, José M.; Louapre, Céline; Lubetzki, Catherine; Luyt, Charles-Edouard; Lye, David C.; Mansouri, Davood; Marjani, Majid; Pereira, Jesus Marquez; Martin, Andrea; Pueyo, David Martínez; Marzana, Iciar; Mathian, Alexis; Matos, Larissa R. B.; Matthews, Gail V.; Mège, Jean-Louis; Melki, Isabelle; Meritet, Jean-François; Metin, Ozge; Meyts, Isabelle; Mezidi, Mehdi; Migeotte, Isabelle; Millereux, Maude; Mirault, Tristan; Mircher, Clotilde; Mirsaeidi, Mehdi; Melián, Abián Montesdeoca; Martinez, Antonio Morales; Morange, Pierre; Mordacq, Clémence; Morelle, Guillaume; Mouly, Stéphane; Muñoz-Barrera, Adrián; Nafati, Cyril; Neves, João Farela; Ng, Lisa F. P.; Medina, Yeray Novoa; Cuadros, Esmeralda Nuñez; Ocejo-Vinyals, J. Gonzalo; Orbak, Zerrin; Oualha, Mehdi; Özçelik, Tayfun; Hammarström, Qiang Pan; Parizot, Christophe; Pascreau, Tiffany; Paz-Artal, Estela; de Diego, Rebeca Pérez; Philippe, Aurélien; Planas-Serra, Laura; Ploin, Dominique; Poissy, Julien; Poncelet, Géraldine; Pouletty, Marie; Quentric, Paul; Raoult, Didier; Rebillat, Anne-Sophie; Reisli, Ismail; Ricart, Pilar; Richard, Jean-Christophe; Rivet, Nadia; Rivière, Jacques G.; Blanch, Gemma Rocamora; Rodrigo, Carlos; Rodriguez-Gallego, Carlos; Rodríguez-Palmero, Agustí; Romero, Carolina Soledad; Rothenbuhler, Anya; Rozenberg, Flore; Ruiz del Prado, Maria Yolanda; Riera, Joan Sabater; Sanchez, Oliver; Sánchez-Ramón, Silvia; Schluter, Agatha; Schmidt, Matthieu; Schweitzer, Cyril E.; Scolari, Francesco; Sediva, Anna; Seijo, Luis M.; Sene, Damien; Senoglu, Sevtap; Seppänen, Mikko R. J.; Ilovich, Alex Serra; Shahrooei, Mohammad; Smadja, David; Sobh, Ali; Moreno, Xavier Solanich; Solé-Violán, Jordi; Soler, Catherine; Soler-Palacín, Pere; Stepanovskiy, Yuri; Stoclin, Annabelle; Taccone, Fabio; Taupin, Jean-Luc; Tavernier, Simon J.; Thumerelle, Caroline; Tomasoni, Gabriele; Toubiana, Julie; Alvarez, Josep Trenado; Troya, Jesús; Tucci, Alessandra; Uzunhan, Yurdagul; Vabres, Pierre; Valencia Ramos, Juan; Van Den Rym, Ana Maria; Vandernoot, Isabelle; Vatansev, Hulya; Vélez-Santamaria, Valentina; Viel, Sébastien; Vilain, Cédric; Vilaire, Marie E.; Vincent, Audrey; Voiriot, Guillaume; Vuotto, Fanny; Yosunkaya, Alper; Young, Barnaby E.; Yucel, Fatih; Zannad, Faiez; Zatz, Mayana; Foti, Giuseppe; Bellani, Giacomo; Citerio, Giuseppe; Contro, Ernesto; Pesci, Alberto; Valsecchi, Maria Grazia; Cazzaniga, Marina; Bole-Feysot, Christine; Lyonnet, Stanislas; Masson, Cécile; Nitschke, Patrick; Pouliet, Aurore; Schmitt, Yoann; Tores, Frederic; Zarhrate, Mohammed; Andrejak, Claire; Angoulvant, François; Bachelet, Delphine; Basmaci, Romain; Behillil, Sylvie; Beluze, Marine; Benkerrou, Dehbia; Bhavsar, Krishna; Bompart, François; Bouadma, Lila; Bouscambert, Maude; Caralp, Mireille; Cervantes-Gonzalez, Minerva; Chair, Anissa; Coelho, Alexandra; Couffignal, Camille; Couffin-Cadiergues, Sandrine; D’ortenzio, Eric; Da Silveira, Charlene; Debray, Marie-Pierre; Deplanque, Dominique; Descamps, Diane; Desvallées, Mathilde; Diallo, Alpha; Diouf, Alphonsine; Dorival, Céline; Dubos, François; Eloy, Philippine; Enouf, Vincent V. E.; Esperou, Hélène; Esposito-Farese, Marina; Etienne, Manuel; Ettalhaoui, Nadia; Gault, Nathalie; Gaymard, Alexandre; Gigante, Tristan; Gorenne, Isabelle; Guedj, Jérémie; Hoctin, Alexandre; Hoffmann, Isabelle; Jaafoura, Salma; Kafif, Ouifiya; Kaguelidou, Florentia; Kali, Sabina; Khalil, Antoine; Khan, Coralie; Laouénan, Cédric; Laribi, Samira; Le, Minh; Le Hingrat, Quentin; Le Mestre, Soizic; Le Nagard, Hervé; Lescure, François-Xavier; Lévy, Yves; Levy-Marchal, Claire; Lina, Bruno; Lingas, Guillaume; Lucet, Jean Christophe; Malvy, Denis; Mambert, Marina; Mentré, France; Mercier, Noémie; Meziane, Amina; Mouquet, Hugo; Mullaert, Jimmy; Neant, Nadège; Noret, Marion; Pages, Justine; Papadopoulos, Aurélie; Paul, Christelle; Peiffer-Smadja, Nathan; Petrov-Sanchez, Ventzislava; Peytavin, Gilles; Picone, Olivier; Puéchal, Oriane; Rosa-Calatrava, Manuel; Rossignol, Bénédicte; Roy, Carine; Schneider, Marion; Semaille, Caroline; Mohammed, Nassima Si; Tagherset, Lysa; Tardivon, Coralie; Tellier, Marie-Capucine; Téoulé, François; Terrier, Olivier; Timsit, Jean-François; Treoux, Théo; Tual, Christelle; Tubiana, Sarah; van der Werf, Sylvie; Vanel, Noémie; Veislinger, Aurélie; Visseaux, Benoit; Wiedemann, Aurélie; Yazdanpanah, Yazdan; Alcover, Andres; Aschard, Hugues; Astrom, Kalla; Bousso, Philippe; Bruhns, Pierre; Cumano, Ana; Demangel, Caroline; Deriano, Ludovic; Di Santo, James; Dromer, Françoise; Eberl, Gérard; Enninga, Jost; Fellay, Jacques; Gomperts-Boneca, Ivo; Hasan, Milena; Hercberg, Serge; Lantz, Olivier; Patin, Etienne; Pellegrini, Sandra; Pol, Stanislas; Rausell, Antonio; Rogge, Lars; Sakuntabhai, Anavaj; Schwartz, Olivier; Schwikowski, Benno; Shorte, Spencer; Tangy, Frédéric; Toubert, Antoine; Touvier, Mathilde; Ungeheuer, Marie-Noëlle; Albert, Matthew L.; Alavoine, Loubna; Amat, Karine K. A.; Bielicki, Julia; Bruijning, Patricia; Burdet, Charles; Caumes, Eric; Charpentier, Charlotte; Coignard, Bruno; Costa, Yolande; Damond, Florence; Dechanet, Aline; Delmas, Christelle; Ecobichon, Jean-Luc; Enouf, Vincent; Espérou, Hélène; Frezouls, Wahiba; Houhou, Nadhira; Ilic-Habensus, Emila; Kikoine, John; Lebeaux, David; Leclercq, Anne; Lehacaut, Jonathan; Letrou, Sophie; Lucet, Jean-Christophe; Manchon, Pauline; Mandic, Milica; Meghadecha, Mohamed; Motiejunaite, Justina; Nouroudine, Mariama; Piquard, Valentine; Postolache, Andreea; Quintin, Caroline; Rexach, Jade; Roufai, Layidé; Terzian, Zaven; Thy, Michael; Vignali, Valérie; van Agtmael, Michiel; Algera, Anna Geke; van Baarle, Frank; Bax, Diane; Beudel, Martijn; Bogaard, Harm Jan; Bomers, Marije; Bos, Lieuwe; Botta, Michela; de Brabander, Justin; Bree, Godelieve; Brouwer, Matthijs C.; de Bruin, Sanne; Bugiani, Marianna; Bulle, Esther; Chouchane, Osoul; Cloherty, Alex; Elbers, Paul; Fleuren, Lucas; Geerlings, Suzanne; Geerts, Bart; Geijtenbeek, Theo; Girbes, Armand; Goorhuis, Bram; Grobusch, Martin P.; Hafkamp, Florianne; Hagens, Laura; Hamann, Jorg; Harris, Vanessa; Hemke, Robert; Hermans, Sabine M.; Heunks, Leo; Hollmann, Markus W.; Horn, Janneke; Hovius, Joppe W.; de Jong, Menno D.; Koning, Rutger; van Mourik, Niels; Nellen, Jeaninne; Paulus, Frederique; Peters, Edgar; van der Poll, Tom; Preckel, Benedikt; Prins, Jan M.; Raasveld, Jorinde; Reijnders, Tom; Schinkel, Michiel; Schultz, Marcus J.; Schuurman, Alex; Sigaloff, Kim; Smit, Marry; Stijnis, Cornelis S.; Stilma, Willemke; Teunissen, Charlotte; Thoral, Patrick; Tsonas, Anissa; van der Valk, Marc; Veelo, Denise; Vlaar, Alexander P. J.; de Vries, Heder; van Vugt, Michèle; Wiersinga, W. Joost; Wouters, Dorien; Zwinderman, A. H. (Koos); Al Muhsen, Saleh; Al-Mulla, Fahd; Anderson, Mark S.; Bogunovic, Dusan; Bondarenko, Anastasiia; Bryceson, Yenan; Bustamante, Carlos D.; Butte, Manish; Chakravorty, Samya; Christodoulou, John; Cirulli, Elizabeth; Condino-Neto, Antonio; Cooper, Megan A.; DeRisi, Joseph L.; Desai, Murkesh; Drolet, Beth A.; Espinosa, Sara; Franco, Jose Luis; Gregersen, Peter K.; Hagin, David; Heath, Jim; Henrickson, Sarah E.; Hsieh, Elena; Imai, Kohsuke; Itan, Yuval; Karamitros, Timokratis; Ku, Cheng-Lung; Ling, Yun; Lucas, Carrie L.; Maniatis, Tom; Mansouri, Davoud; Marodi, Laszlo; Milner, Joshua D.; Mironska, Kristina; Mogensen, Trine; Morio, Tomohiro; Novelli, Giuseppe; Novelli, Antonio; O'Farrelly, Cliona; Okada, Satoshi; Ozcelik, Tayfun; de Diego, Rebeca Perez; Planas, Anna M.; Prando, Carolina; Pujol, Aurora; Renia, Laurent; Renieri, Alessandra; Sancho-Shimizu, Vanessa; Sankaran, Vijay; Barrett, Kelly Schiabor; Shahrooei, Mohammed; Snow, Andrew; Tangye, Stuart; Turvey, Stuart; Uddin, Furkan; Uddin, Mohammed J.; Vazquez, Sara E.; von Bernuth, Horst; Washington, Nicole; Zawadzki, Pawel |
| Publisher Information: |
American Association for the Advancement of Science |
| Publication Year: |
2020 |
| Collection: |
Repositorio Institucional de la Universidad de Burgos (RIUBU) |
| Subject Terms: |
Medicina; Medicine |
| Description: |
Interindividual clinical vari-ability is vast in humans infected withsevere acute respiratory syndrome corona-virus 2 (SARS-CoV-2), ranging from silent in-fection to rapid death. Three risk factors forlife-threatening coronavirus disease 2019(COVID-19) pneumonia have been identified—being male, being elderly, or having othermedical conditions—but these risk factorscannot explain why critical disease remainsrelatively rare in any given epidemiologicalgroup. Given the rising toll of the COVID-19pandemic in terms of morbidity and mortality,understanding the causes and mechanisms oflife-threatening COVID-19 is crucial. ; The Laboratory of Human Genetics of Infectious Diseases is supported by the Howard Hughes Medical Institute, The Rockefeller University, the St. Giles Foundation, the National Institutes of Health (NIH) (R01AI088364), the National Center for Advancing Translational Sciences (NCATS), NIH Clinical and Translational Science Award (CTSA) program (UL1 TR001866), a Fast Grant from Emergent Ventures, the Mercatus Center at George Mason University, the Yale Center for Mendelian Genomics and the GSP Coordinating Center funded by the National Human Genome Research Institute (NHGRI) (UM1HG006504 and U24HG008956), the French National Research Agency (ANR) under the Investments for the Future program (ANR-10-IAHU-01), the Integrative Biology of Emerging Infectious Diseases Laboratory of Excellence (ANR-10-LABX-62-IBEID), the French Foundation for Medical Research (FRM) (EQU201903007798), the FRM and ANR GENCOVID project (ANRS-COV05), the Square Foundation, Grandir – Fonds de solidarité pour l’enfance, the SCOR Corporate Foundation for Science, the Institut Institut National de la Santé et de la Recherche Médicale (INSERM), and the University of Paris. Samples from San Raffaele Hospital were obtained through the Covid-BioB project and by healthcare personnel of San Raffaele Hospital, San Raffaele Telethon Institute for Gene Therapy (SR-TIGET) clinical laboratory and clinical research unit, funded by the Program ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
Spanish; Castilian |
| Relation: |
Science. 2020, V. 370, n. 6515; https://doi.org/10.1126/science.abd4585; http://hdl.handle.net/10259/10039 |
| DOI: |
10.1126/science.abd4585 |
| Availability: |
http://hdl.handle.net/10259/10039; https://doi.org/10.1126/science.abd4585 |
| Rights: |
Atribución 4.0 Internacional ; http://creativecommons.org/licenses/by/4.0/ ; info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.A5AD9CBA |
| Database: |
BASE |