| Contributors: |
Heffler, E.; Macchi, A.; Pasquini, E.; Cantone, E.; De Corso, E.; Gallo, S.; Malvezzi, L.; Seccia, V.; Senna, G.; Castelnuovo, P.; Canonica, G.W.; Anastasi, F.; Bagnasco, D.; Benfante, A.; Bergia, R.; Berni Canani, F.; Bignami, M.; Bocciolini, C.; Bonacina, C.; Bresciani, M.D.M.; Bruno, G.; Brussino, L.; Caiaffa, M.F.; Cameli, P.; Canevari, F.R.M.; Caruso, M.; Cassiano, B.; Cocchi, R.; Colangelo, C.; Conte, M.E.; Contini, P.; Corbò, M.; Cristofani Mencacci, L.; Crivellaro, M.; D'Alessio, P.; De Massimi, A.; Deleonardi, G.; Detoraki, A.; Di Fulvio, F.; Di Nola, C.; Fadda, G.; Garzaro, M.; Giancaspro, R.; Giombi, F.; Giorli, A.; Guida, G.; Iannuzzi, L.; Imperatore, C.; La Mantia, I.; Maggiore, G.; Maselli Del Giudice, A.; Masnaghetti, D.; Mazzola, M.; Moro, D.; Murzilli, F.; Napolitano, M.; Nebiolo, F.; Nettis, E.; Oretti, G.; Ottaviano, G.; Paoletti, G.; Parazzini, E.; Pinter, P.; Pipolo, C.; Porto, M.; Puxeddu, I.; Quarta, F.; Raimondo, L.; Ridolo, E.; Rivolta, F.; Rizzi, A.; Romano, A.; Schiappoli, M.; Scioscia, G.; Sireci, F.; Sovardi, F.; Torretta, S.; Varini, A.; Varricchi, G.; Vassallo, F.G.; Vassallo, S.; Vultaggio, A.; Zisa, G. |
| Description: |
Background: The concept of clinical remission in chronic rhinosinusitis with nasal polyps (CRSwNP) is gaining growing relevance in the era of biologic therapies. However, current definitions remain heterogeneous and lack standardized, operational criteria. This variability limits comparability across studies and hinders the implementation of remission as a therapeutic target in routine practice. Objective: To develop a multidisciplinary, evidence-based, and clinically applicable definition of clinical remission in CRSwNP, integrating symptom-based, endoscopic, therapeutic, and timing-related criteria, and to evaluate expert consensus on the development of a composite remission score. Methods: A 3-round Delphi consensus was conducted among experts participating in the Rhinosinusitis Italian Network. Across the 3 rounds, experts rated the statements using a 5-point Likert scale. Positive or negative consensus was defined as ≥70% agreement or disagreement, respectively. Descriptive statistics assessed the convergence and stability of responses. Results: Experts agreed that remission requires meeting concurrent criteria across 4 domains: timing (≥12 months), absence of systemic corticosteroid use or surgical indication, symptom thresholds (Sino-Nasal Outcome Test-22 |