| Title: |
Soft, skin-interfaced microfluidic systems with integrated immunoassays, fluorometric sensors and impedance measurement capabilities |
| Authors: |
Kim, Sungbong; Lee, Boram; Reeder, Jonathan; Seo, Seon Hee; Lee, Sung-Uk; Hourlier-Fargette, Aurélie; Shin, Joonchul; Sekine, Yurina; Jeong, Hyoyoung; Oh, Yong Suk; Aranyosi, Alexander; Lee, Stephen; Model, Jeffrey; Lee, Geumbee; Seo, Min-Ho; Kwak, Sung Soo; Jo, Seongbin; Park, Gyungmin; Han, Sunghyun; Park, Inkyu; Jung, Hyo-Il; Ghaffari, Roozbeh; Koo, Jahyun; Braun, Paul; Rogers, John |
| Contributors: |
Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA; Department of Materials Science and Engineering and Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA; Department of Medicine, Konkuk University, Seoul 05029, Republic of Korea; Northwestern University Evanston; Nano Hybrid Technology Research Center, Electrical Materials Research Division, Korea Electrotechnology Research Institute, Changwon 51543, Republic of Korea; ATF Technology Development Division, Korea Atomic Energy Research Institute, Daejeon, 34057, Republic of Korea; Institut Charles Sadron (ICS); Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique; Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Matériaux et nanosciences d'Alsace (FMNGE); Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS); Center for Electronic Materials, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea; Materials Sciences Research Center, Japan Atomic Energy Agency, Tokai, Ibaraki 319-1195, Japan; Department of Mechanical Engineering, Korea Advanced Institute of Science and Technology, Daejeon, 34141, Republic of Korea; Epicore Biosystems, Inc. Cambridge, MA 02139, USA; Department of Chemical and Biomolecular Engineering and Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA; School of Mechanical Engineering, Yonsei University, Seoul 03722, Republic of Korea; School of Biomedical Engineering, Korea University, Seoul 02841, Republic of Korea |
| Source: |
ISSN: 0027-8424. |
| Publisher Information: |
HAL CCSD; National Academy of Sciences |
| Publication Year: |
2020 |
| Collection: |
Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) |
| Subject Terms: |
epidermal devices; galvanic skin response; healthcare; soft materials; sweat cortisol; MESH: Biosensing Techniques; MESH: Dielectric Spectroscopy; MESH: Microfluidics; MESH: Skin; MESH: Sweat; MESH: Wearable Electronic Devices; MESH: Electric Impedance; MESH: Equipment Design; MESH: Fluorometry; MESH: Humans; MESH: Immunoassay; MESH: Lab-On-A-Chip Devices; [SDV.IB]Life Sciences [q-bio]/Bioengineering |
| Description: |
International audience ; Soft microfluidic systems that capture, store, and perform biomarker analysis of microliter volumes of sweat, in situ, as it emerges from the surface of the skin, represent an emerging class of wearable technology with powerful capabilities that complement those of traditional biophysical sensing devices. Recent work establishes applications in the real-time characterization of sweat dynamics and sweat chemistry in the context of sports performance and healthcare diagnostics. This paper presents a collection of advances in biochemical sensors and microfluidic designs that support multimodal operation in the monitoring of physiological signatures directly correlated to physical and mental stresses. These wireless, battery-free, skin-interfaced devices combine lateral flow immunoassays for cortisol, fluorometric assays for glucose and ascorbic acid (vitamin C), and digital tracking of skin galvanic responses. Systematic benchtop evaluations and field studies on human subjects highlight the key features of this platform for the continuous, noninvasive monitoring of biochemical and biophysical correlates of the stress state. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/33106394; hal-03414153; https://hal.archives-ouvertes.fr/hal-03414153; https://hal.archives-ouvertes.fr/hal-03414153/document; https://hal.archives-ouvertes.fr/hal-03414153/file/Kim_Rogers_2020_with_figures.pdf; PUBMED: 33106394; PUBMEDCENTRAL: PMC7668081 |
| DOI: |
10.1073/pnas.2012700117 |
| Availability: |
https://hal.archives-ouvertes.fr/hal-03414153; https://hal.archives-ouvertes.fr/hal-03414153/document; https://hal.archives-ouvertes.fr/hal-03414153/file/Kim_Rogers_2020_with_figures.pdf; https://doi.org/10.1073/pnas.2012700117 |
| Rights: |
info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.A5F51F97 |
| Database: |
BASE |