| Title: |
Therapeutic Vaccinations with p210 Peptides in Imatinib-Treated Chronic Myeloid Leukemia Patients: 10 Years Follow-Up of GIMEMA CML0206 and SI0207 Studies |
| Authors: |
Sicuranza A.; Breccia M.; Iuliano F.; Gugliotta G.; Castagnetti F.; Lunghi M.; Patriarca A.; Intermesoli T.; Luciano L.; Russo Rossi A.; Rege Cambrin G.; Vucinic V.; Malagola M.; Malato A.; Abruzzese E.; D'Adda M.; Galimberti S.; Defina M.; Sammartano V.; Cafarelli C.; Cencini E.; Cartocci A.; Pacelli P.; Piciocchi A.; Rughini A.; Niederwieser D.; Bocchia M. |
| Contributors: |
Sicuranza, A.; Breccia, M.; Iuliano, F.; Gugliotta, G.; Castagnetti, F.; Lunghi, M.; Patriarca, A.; Intermesoli, T.; Luciano, L.; Russo Rossi, A.; Rege Cambrin, G.; Vucinic, V.; Malagola, M.; Malato, A.; Abruzzese, E.; D'Adda, M.; Galimberti, S.; Defina, M.; Sammartano, V.; Cafarelli, C.; Cencini, E.; Cartocci, A.; Pacelli, P.; Piciocchi, A.; Rughini, A.; Niederwieser, D.; Bocchia, M. |
| Publisher Information: |
Multidisciplinary Digital Publishing Institute (MDPI) |
| Publication Year: |
2025 |
| Collection: |
Sapienza Università di Roma: CINECA IRIS |
| Subject Terms: |
CML; imatinib; immune therapy; peptide; vaccine |
| Description: |
Background: We previously showed that peptides encompassing the unique b3a2 or b2a2 breakpoint amino-acid sequence of oncogenic p210 induced peptide-specific T-cell responses in chronic myeloid leukemia (CML) patients. Methods: From 2007 to 2011, two multicenter peptide vaccine phase II studies, GIMEMA CML0206 and SI0207, enrolling overall 109 CML patients (68 b3a2 and 41 b2a2) with persistence of molecular disease during imatinib treatment, were carried out. Peptide vaccination schedule included the following: “immunization phase” (six vaccinations every 2 weeks); “reinforcement” phase (three monthly boosts) and “maintenance” phase (two boosts at 3-month intervals). GM-CSF (granulocyte-macrophage-colony-stimulating factor, sarmograstim) served as the immunological adjuvant. Results: The short-term results (at completion of vaccine protocol—12 months) and long-term follow-up are reported. All patients completed the vaccination schedule with no toxicity. After vaccinations, the BCR::ABL1 peptide-specific CD4+ T-cell response was documented in 80% of patients. In the short term, 30% of patients achieved a reduction in BCR::ABL1, while the majority showed stable molecular disease with fluctuations. The median follow-up since diagnosis and last vaccination are 18 and 10 years, respectively, with an overall survival (OS) rate at 18 years of 89%. In addition, 97/109 (89%) patients are alive, while 12/109 (11%) died of CML-unrelated reasons. Overall, 18/109 (16.5%) patients are in treatment-free remission (TFR) for a median time of 48 months. Conclusions: The long-term results of p210 peptide vaccinations in CML patients with persisting disease during imatinib treatment showed its feasibility, safety, absence of off-targets events, high OS and not negligible rate of successful TFR. Active immunotherapeutic approaches in CML patients with low disease burden, eventually employing newer vaccine strategies such as mRNA vaccines, may be reconsidered. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
volume:13; issue:4; journal:VACCINES; https://hdl.handle.net/11573/1746527 |
| DOI: |
10.3390/vaccines13040419 |
| Availability: |
https://hdl.handle.net/11573/1746527; https://doi.org/10.3390/vaccines13040419 |
| Accession Number: |
edsbas.A5FB3F4E |
| Database: |
BASE |