| Title: |
Trends in fatal poisoning among medical users of analgesics in France from 2013 to 2022: an analysis of the DTA register |
| Authors: |
Revol, Bruno; Willeman, Théo; Manceau, Marc; Dumestre-Toulet, Véronique; Gaulier, Jean-Michel; Eysseric-Guérin, Hélène; Fouilhé Sam-Laï, N.; Abbara, Chadi; Allorge, Delphine; Alvarez, Jean-Claude; Ameline, Alice; Barret, Anne; Berland, Emilie; Bertin, Célian; Besnard, Thierry; Bevalot, Fabien; Billet-Chatenay, Camille; Boucher, Alexandra; Bouquet, Émilie; Bourgine, Joanna; Brunet, Bertrand; Caous, Anne-Sylvie; Cesbron, Alexandre; Charuel, Lauriane; Cheze, Marjorie; Citterio-Quentin, Antony; Collon-Fabie, Philippe; Dailly, Eric; Daveluy, Amélie; Deffontaine, Grégory; Delage, Martine; Delavenne, Xavier; Descamps, Florence; Descoeur, Juliette; Deslandes, Guillaume; Deveaux, Marc; Devos, Bernadette; Doche, Christophe; Eiden, Céline; Fouley, Aurélie; Gaillard, Yvan; Gambier, Nicolas; Ganière, Catherine; Gérardin, Marie; Goullé, Jean-Pierre; Guerard, Pascal; Hoizey, Guillaume; Humbert, Luc; Imbert, Laurent; Kergueris, Marie-France; Kintz, Pascal; Klinzig, Florian; Labat-Deveaux, Laurence; Lacarelle, Bruno; Lacroix, Christian; Lamiable, Denis; Lavit, Michel; Le Boisselier, Reynald; Le Bouil, Anne; Le Meur, Catherine; Lefeuvre, Sandrine; Lelièvre, Bénédicte; Lelong-Boulouard, Véronique; Lemaire-Hurtel, Anne-Sophie; Loilier, Magalie; Lopez, Vincent; Martin-Molins, Claire; Marty, Hélène; Mathieu, Olivier; Mathieu-Daudé, Jean-Claude; Mauras, Yves; Milan, Nathalie; Moal, Aurélie; Morel, Isabelle; Mura, Patrick; Pelissier-Alicot, Anne-Laure; Pépin, Gilbert; Perrin, Martine; Peyre, Anne; Pineau, Alain; Pochard, Liselotte; Pok, Rop; Ragoucy-Sengler, Catherine; Rayer, Raphaël; Redjimi, Nassima; Roman, Emilie; Roussel, Carine; Sabini, Sandrine; Saussereau, Elodie; Scala-Bertola, Julien; Sibille, Pauline; Spadari, Michel; Thiery, Johan; Titier, Karine; Turcant, Alain; Vacher, Pierrick; Venisse, Nicolas; Vieira, Ophélie; Visinoni, Pascale |
| Contributors: |
Université Grenoble Alpes - UFR Médecine (UGA UFRM); Université Grenoble Alpes (UGA); CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble (CHUGA); Hypoxie et PhysioPathologie (HP2); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA); Centre d'Investigation Clinique Grenoble (CIC Grenoble); CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble (CHUGA)-Hôpital Michallon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA); Laboratoire ToxGen (ToxGen); Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille); Département de Pharmacologie-Toxicologie CHU Angers; Centre Hospitalier Universitaire d'Angers (CHU Angers); Impact de l'environnement chimique sur la santé humaine - ULR 4483 (IMPECS); Université de Lille-Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille); Plateforme de spectrométrie de masse Garches (MasSpecLab); Infection et inflammation (2I); Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM); Hôpital Raymond Poincaré AP-HP; Institut de Médecine Légale Strasbourg; Université de Strasbourg (UNISTRA); Laboratoire de pharmacologie et toxicologie neurocardiovasculaire (LPTNC); CHU Gabriel Montpied Clermont-Ferrand; CHU Clermont-Ferrand; Université Clermont Auvergne (UCA); Neuro-Dol (Neuro-Dol); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne (UCA); Laboratoire Lat Lumtox; Hospices Civils de Lyon (HCL); Laboratoire de neurosciences expérimentales et cliniques U 1084 (LNEC Poitiers ); Université de Poitiers = University of Poitiers (UP)-Institut National de la Santé et de la Recherche Médicale (INSERM); CIC de Poitiers – Centre d'investigation clinique de Poitiers (CIC 1402) (CIC 1402); Université de Poitiers = University of Poitiers (UP)-Centre hospitalier universitaire de Poitiers = Poitiers University Hospital (CHU de Poitiers La Milétrie )-Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale (INSERM); Service de pharmacologie clinique et vigilances CHU de Poitiers; Centre hospitalier universitaire de Poitiers = Poitiers University Hospital (CHU de Poitiers La Milétrie ); Département de Pharmacologie CHU Caen; Université de Caen Normandie (UNICAEN); Normandie Université (NU)-Normandie Université (NU)-CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie (CHU Caen Normandie); Normandie Université (NU); Université Jean Monnet - Saint-Étienne (UJM); Santé Ingénierie Biologie Saint-Etienne (SAINBIOSE); Centre Ingénierie et Santé (CIS-ENSMSE); École des Mines de Saint-Étienne (Mines Saint-Étienne MSE); Institut Mines-Télécom Paris (IMT)-Institut Mines-Télécom Paris (IMT)-École des Mines de Saint-Étienne (Mines Saint-Étienne MSE); Institut Mines-Télécom Paris (IMT)-Institut Mines-Télécom Paris (IMT)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM); Centre Hospitalier Universitaire de Saint-Etienne CHU Saint-Etienne (CHU ST-E); Institut de Neurosciences des Systèmes (INS); Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| Source: |
ISSN: 0033-3506. |
| Publisher Information: |
CCSD; Elsevier |
| Publication Year: |
2024 |
| Collection: |
Université de Versailles Saint-Quentin-en-Yvelines: HAL-UVSQ |
| Subject Terms: |
Opioids; Analgesics; Addictovigilance; Drug-related deaths; MESH: Adult; MESH: Aged; MESH: Analgesics; Opioid / adverse effects; Opioid / poisoning; MESH: Drug Overdose / mortality; MESH: Female; MESH: France / epidemiology; MESH: Humans; MESH: Male; MESH: Middle Aged; MESH: Registries; MESH: Tramadol / adverse effects; MESH: Tramadol / poisoning; MESH: Young Adult; MESH: Analgesics* / adverse effects; MESH: Analgesics* / poisoning; [SDV]Life Sciences [q-bio] |
| Description: |
International audience ; Objective: To describe analgesic-related deaths in France and report trends over a 10-year period. Study design: The DTA (“Décès Toxiques par Antalgiques”) register is a French database of analgesic-related deaths among people without a history of drug abuse, reported by forensic toxicology experts. Methods: We included analgesic-related deaths occurring from January 2013 to December 2022 in France. Subject demographic characteristics and medical history, forensic autopsy findings, and toxicology reports were evaluated. Results: Among the 1036 deceased individuals (mean [SD] age, 48.3 [15.6] years), there were slightly more women than men (M:F sex ratio, 0.89:1). Over the entire study period, tramadol was the leading cause of death, ahead of morphine. A relative increase in oxycodone-related mortality was observed (from 6.8% in 2013 to 21.1% in 2022) compared to a progressive decrease in tramadol, morphine, and codeine-related deaths (from 43.2%, 31.1% and 24.3% in 2013 to 37.5%, 26.6% and 20.3% in 2022, respectively). However, no statistically significant variations were found (Chi-squared tests of homogeneity). Other analgesics (buprenorphine, dihydrocodeine, fentanyl, gabapentin, ketamine, methadone, nefopam, and pregabalin) were also implicated in deaths, but with low and stable rates over the period studied. Conclusions: In France, no increase in fentanyl-related deaths and only a non-significant increase in oxycodone-related deaths were observed over the period 2013–2022. Tramadol was the leading cause of analgesic-related deaths throughout this period. Although close monitoring is still required, particularly for oxycodone, our data do not support the hypothesis of an opioid crisis in France. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/39303626; PUBMED: 39303626 |
| DOI: |
10.1016/j.puhe.2024.08.019 |
| Availability: |
https://hal.science/hal-04977982; https://hal.science/hal-04977982v2/document; https://hal.science/hal-04977982v2/file/1-s2.0-S0033350624003652-main.pdf; https://doi.org/10.1016/j.puhe.2024.08.019 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.A61CBAFF |
| Database: |
BASE |