| Title: |
Cerebellar lncRNA Expression Profile Analysis of SCA3/MJD Mice |
| Authors: |
Long, Zhe; Li, Tianjiao; Chen, Zhao; Peng, Yun; Wang, Chunrong; Hou, Xiaocan; Yuan, Hongyu; Wang, Puzhi; Xie, Yue; He, Lang; Zhou, Xin; Peng, Huirong; Qiu, Rong; Xia, Kun; Tang, Beisha; Jiang, Hong |
| Contributors: |
Independent Exploration and Innovation Project of Graduate Student of Central South University; Youth Foundation of Xiangya Hospital; Clinical and Rehabilitation Fund of Peking University Weiming Biotech Group; Clinical Research Funds of Xiangya Hospital; National Key Research and Development Program of China; National Natural Science Foundation of China |
| Source: |
International Journal of Genomics ; volume 2018, page 1-6 ; ISSN 2314-436X 2314-4378 |
| Publisher Information: |
Wiley |
| Publication Year: |
2018 |
| Collection: |
Wiley Online Library (Open Access Articles via Crossref) |
| Description: |
Spinocerebellar ataxia type 3 (SCA3) or Machado-Joseph disease (MJD) is the most common autosomal dominant spinocerebellar ataxia in China with highly clinical heterogeneity, such as progressive cerebellar ataxia, dysarthria, pyramidal signs, external ophthalmoplegia, dysphagia, and distal muscle atrophy. It is caused by the abnormal expansion of CAG repeats in a coding region of ATXN3 . However, by focusing on the ATXN3 itself cannot fully explain the heterogeneous clinical features of SCA3/MJD. With the discovery of the increasing number of long noncoding RNAs (lncRNAs) that are believed to be involved in spinocerebellar ataxia type 8 (SCA8) and Huntington disease (HD), we wonder whether the lncRNAs are differentially expressed in the SCA3/MJD patients compared to the nonpatients. As the first step, we used lncRNA-Seq to investigate differential expression of the lncRNAs in the SCA3/MJD mice. Two known lncRNAs, n297609 and n297477, and a novel lncRNA TCONS_00072962 have been identified in SCA3/MJD mice with abnormal expression. The first discovery of the novel lncRNA TCONS_00072962 enriched the lncRNA expression profile in the SCA3/MJD mouse model. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1155/2018/5383517 |
| Availability: |
https://doi.org/10.1155/2018/5383517; http://downloads.hindawi.com/journals/ijg/2018/5383517.pdf; http://downloads.hindawi.com/journals/ijg/2018/5383517.xml |
| Rights: |
http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.A64055DE |
| Database: |
BASE |