| Title: |
Epigenome-Wide Associations of Placental DNA Methylation and Behavioral and Emotional Difficulties in Children at 3 Years of Age |
| Authors: |
Nakamura, Aurélie; Broséus, Lucile; Tost, Jörg; Vaiman, Daniel; Martins, Silvia; Keyes, Katherine; Bonello, Kim; Fekom, Mathilde; Strandberg-Larsen, Katrine; Sutter-Dallay, Anne-Laure; Heude, Barbara; Melchior, Maria; Lepeule, Johanna |
| Contributors: |
Centre National de Recherche en Génomique Humaine (CNRGH); Institut de Biologie François JACOB (JACOB); Direction de Recherche Fondamentale (CEA) (DRF (CEA)); Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)); Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA); Bordeaux population health (BPH); Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM); Centre for Research in Epidemiology and Statistics; Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE); Institut pour la Recherche en Santé Publique; Institut National Du Cancer; Fondation pour la Recherche Médicale; Ministère de la Santé; Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail; Mutuelle Générale de l'Education Nationale; ANR-18-CE36-0005,ETAPE,Exposition prénatale au tabac et à la pollution atmosphérique et effets sur la santé respiratoire et le neurodévelopment de l'enfant: rôle de la méthylation placentaire(2018); European Project: 714532,ERC-2016-STG,ERC-2016-STG,PowAlgDO(2017) |
| Source: |
ISSN: 1661-6596. |
| Publisher Information: |
CCSD; MDPI |
| Publication Year: |
2023 |
| Collection: |
Inserm: HAL (Institut national de la santé et de la recherche médicale) |
| Subject Terms: |
Fetus; Emotions; Epigenome; Placenta; DNA Methylation; Pregnancy; Female; Humans; Male; [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie |
| Description: |
International audience ; The placenta is a key organ for fetal and brain development. Its epigenome can be regarded as a biochemical record of the prenatal environment and a potential mechanism of its association with the future health of the fetus. We investigated associations between placental DNA methylation levels and child behavioral and emotional difficulties, assessed at 3 years of age using the Strengths and Difficulties Questionnaire (SDQ) in 441 mother-child dyads from the EDEN cohort. Hypothesis-driven and exploratory analyses (on differentially methylated probes (EWAS) and regions (DMR)) were adjusted for confounders, technical factors, and cell composition estimates, corrected for multiple comparisons, and stratified by child sex. Hypothesis-driven analyses showed an association of cg26703534 () with emotional symptoms, and exploratory analyses identified two probes, cg09126090 (intergenic region) and cg10305789 (), as negatively associated with peer relationship problems, as well as 33 DMRs, mostly positively associated with at least one of the SDQ subscales. Among girls, most associations were seen with emotional difficulties, whereas in boys, DMRs were as much associated with emotional than behavioral difficulties. This study provides the first evidence of associations between placental DNA methylation and child behavioral and emotional difficulties. Our results suggest sex-specific associations and might provide new insights into the mechanisms of neurodevelopment. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/37511531; info:eu-repo/grantAgreement//714532/EU/Power of Algorithms in Discrete Optimisation/PowAlgDO; PUBMED: 37511531; WOS: 001036180300001 |
| DOI: |
10.3390/ijms241411772 |
| Availability: |
https://hal.science/hal-04245800; https://hal.science/hal-04245800v1/document; https://hal.science/hal-04245800v1/file/BPH_IntJMolSci_2023_Nakamura.pdf; https://doi.org/10.3390/ijms241411772 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.A67DF876 |
| Database: |
BASE |