Co-infection and ICU-acquired infection in COIVD-19 ICU patients: a secondary analysis of the UNITE-COVID data set
| Title: | Co-infection and ICU-acquired infection in COIVD-19 ICU patients: a secondary analysis of the UNITE-COVID data set |
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| Authors: | Conway Morris A.; Kohler K.; De Corte T.; Ercole A.; De Grooth H. -J.; Elbers P. W. G.; Povoa P.; Morais R.; Koulenti D.; Jog S.; Nielsen N.; Jubb A.; Cecconi M.; De Waele J.; Bezzi M.; Gira A.; Eller P.; Hamid T.; Haque I. U.; De Buyser W.; Cudia A.; De Backer D.; Foulon P.; Collin V.; Van Hecke J.; De Waele E.; Van Malderen C.; Mesland J. -B.; Piagnerelli M.; Haentjens L.; De Schryver N.; Van Leemput J.; Vanhove P.; Bulpa P.; Ilieva V.; Katz D.; Geagea A.; Binnie A.; Tirapegui F.; Lago G.; Graf J.; Perez-Araos R.; Vargas P.; Martinez F.; Labarca E.; Franco D. M.; Parra-Tanoux D.; Reyes L. F.; Yepes D.; Periš F.; Stipic S. S.; Burgos C. V. C.; Boada P. R. N.; Brun J. L. B.; Ballesteros J. P. P.; Hammouda A.; Elmandouh O.; Azzam A.; Hussein A. M.; Galal I.; Awad A. K.; Azab M. A.; Abdalla M.; Assal H.; Alfishawy M.; Ghozy S.; Tharwat S.; Eldaly A.; Reinhard V.; Chrisment A.; Poyat C.; Badie J.; Ferrari F. B.; Weiss B.; Kuhn K. F.; Grunow J. J.; Lorenz M.; Schaller S.; Spieth P.; Bota M.; Fichtner F.; Fuest K.; Lahmer T.; Herrmann J.; Meybohm P.; Markou N.; Vasileiadou G.; Chrysanthopoulou E.; Papamichalis P.; Soultati I.; Kalvit K.; Myatra S. N.; Krupa I.; Tharwat A.; Nichol A.; McCarthy A.; Mahmoodpoor A.; Tonetti T.; Isoni P.; Spadaro S.; Volta C. A.; Mirabella L.; Noto A.; Florio G.; Guzzardella A.; Paleari C.; Baccanelli F.; Savi M.; Antonelli M.; Vaccarini B.; Montrucchio G.; Sales G.; Donadello K.; Gottin L.; Polati E.; De Rosa S.; Sulemanji D.; Abusalama A.; Elhadi M.; De Jesus M. F.; Gonzalez D. R.; Canedo N.; Chavez A. E.; Dendane T.; Grady B.; de Jong B.; van der Heiden E.; Thoral P.; van den Bogaard B.; Spronk P. E.; Achterberg S.; Groeneveld M.; So R. K. L.; de Wijs C.; Scholten H.; Beishuizen A.; Cornet A. D.; Reidinga A. C.; Kranen H.; Mensink R.; Boer S.; de Groot M.; Beck O.; Bethlehem C.; van Bussel B.; Frenzel T.; de Jong C.; Wilting R.; Kesecioglu J.; Mehagnoul-Schipper J.; Alasia D.; Kumar A.; Qayyum A.; Rana M.; Jayyab M. A.; Sierra R. Q.; Hernandez A. M.; Taborda L.; Ramires T.; Silva C.; Roriz C.; Patricio P.; Santos M. L.; Costa V.; Cunha P.; Gonçalves C.; Nunes S.; Camões J.; Adrião D.; Oliveira A.; Omrani A.; Al Maslamani M.; elbuzidi A. S.; Al qudah B. M.; Akkari A. R.; Alkhatteb M.; Baiou A.; Husain A.; Alwraidat M.; Saif I. A.; Bakdach D.; Ahmed A.; Aleef M.; Bintaher A.; Petrisor C.; Popov E.; Popova K.; Dementienko M.; Teplykh B.; Pyregov A.; Davydova L.; Vladislav B.; Neporada E.; Zverev I.; Meshchaninova S.; Sokolov D.; Gavrilova E.; Shlyk I.; Poliakov I.; B?aco?a M.; Aljuhani O.; Alkhalaf A.; Humaid F. B.; Arabi Y.; Kuhail A.; Elrabi O.; Alghnam M.; Kansal A.; Ho V. K.; Ng J.; García R. R.; Fraga X. T.; del Pilar García-Bonillo M.; Padilla-Serrano A.; Cuadrado M. M.; Ferrando C.; Catalan-Monzon I.; Galarza L.; Frutos-Vivar F.; Jimenez J.; Rodríguez-Solis C.; Franquesa-Gonzalez E.; Acosta G. P.; Cabrera L. S.; Parra J. P. A.; Gonzalez F. M.; del Carmen Lorente Conesa M.; Varela I. Y. M.; Pravia O. V. B.; Delgado M. C. M.; de Cabo C. M.; Ioan A. -M.; Perez-Calvo C.; Santos A.; Abad-Motos A.; Ripolles-Melchor J.; Martin B. C.; Teruel S. Y.; Lucas J. H.; Ortiz A. B.; de Pablo Sánchez R.; Barrueco-Francioni J. E.; Espina L. F.; Bonell-Goytisolo J. M.; Salaverria I.; Mir A. S.; Rodriguez-Ruiz E.; Valverde V. H.; Cubero P. J.; Linde F. A.; Leganes N. C.; Romeu J. M.; Concha P.; Berezo-Garcia J. A.; Fraile V.; Cuenca-Rubio C.; Perez-Torres D.; Serrano A.; Valero C. M.; Suner A. O.; Larrañaga L.; Legaristi N.; Ferrigno G.; Khlafalla S.; Bihariesingh-Sanchit R.; Zoerner F.; Grip J.; Kilsand K.; Österlind J.; von Seth M.; Berkius J.; Ceruti S.; Glotta A.; Izdes S.; Turan I. Ö.; Cosar A.; Halacli B.; Dereli N.; Yilmaz M.; Akbas T.; Elay G.; Eyüpoglu S.; Bílír Y.; Saraçoglu K. T.; Kaya E.; Sahin A. S.; Ekren P. K.; Mengi T.; Suner K. O.; Tomak Y.; Eroglu A.; Alsabbah A.; Hanlon K.; Gervin K.; McMahon S.; Hagan S.; Higenbottam C. V.; Mullhi R.; Poulton L.; Torlinski T.; Gareth A.; Truman N.; Vijayakumar G.; Hall C.; Cagova L.; Jones N.; Graham S.; Robin N.; Cowton A.; Donnelly A.; Singatullina N.; Kent M.; Boulanger C.; Campbell Z.; Potter E.; Duric N.; Szakmany T.; Kviatkovske O.; Marczin N.; Ellis C.; Saha R.; Sri-Chandana C.; Allan J.; Mumelj L.; Venkatesh H.; Gotz V. N.; Cochrane A.; Lumlertgul N.; Ficial B.; Jain S.; Crapelli G. B.; Vlachou A.; Golden D.; Garrioch S.; Henning J.; Loveleena G.; Davey M.; Grauslyte L.; Salciute-Simene E.; Cook M.; Barling D.; Broadhurst P.; Purvis S.; Michael S.; Shuker B.; Grecu I.; Harding D.; Dean J. T.; Al-Bayati S.; Al-Sadawi M.; Charron M.; Stubenrauch P.; Santanilla J.; Wentowski C.; Rosenberger D.; Eksarko P.; Jawa R. |
| Contributors: | Conway Morris, A.; Kohler, K.; De Corte, T.; Ercole, A.; De Grooth, H. -J.; Elbers, P. W. G.; Povoa, P.; Morais, R.; Koulenti, D.; Jog, S.; Nielsen, N.; Jubb, A.; Cecconi, M.; De Waele, J.; Bezzi, M.; Gira, A.; Eller, P.; Hamid, T.; Haque, I. U.; De Buyser, W.; Cudia, A.; De Backer, D.; Foulon, P.; Collin, V.; Van Hecke, J.; De Waele, E.; Van Malderen, C.; Mesland, J. -B.; Piagnerelli, M.; Haentjens, L.; De Schryver, N.; Van Leemput, J.; Vanhove, P.; Bulpa, P.; Ilieva, V.; Katz, D.; Geagea, A.; Binnie, A.; Tirapegui, F.; Lago, G.; Graf, J.; Perez-Araos, R.; Vargas, P.; Martinez, F.; Labarca, E.; Franco, D. M.; Parra-Tanoux, D.; Reyes, L. F.; Yepes, D.; Periš, F.; Stipic, S. S.; Burgos, C. V. C.; Boada, P. R. N.; Brun, J. L. B.; Ballesteros, J. P. P.; Hammouda, A.; Elmandouh, O.; Azzam, A.; Hussein, A. M.; Galal, I.; Awad, A. K.; Azab, M. A.; Abdalla, M.; Assal, H.; Alfishawy, M.; Ghozy, S.; Tharwat, S.; Eldaly, A.; Reinhard, V.; Chrisment, A.; Poyat, C.; Badie, J.; Ferrari, F. B.; Weiss, B.; Kuhn, K. F.; Grunow, J. J.; Lorenz, M.; Schaller, S.; Spieth, P.; Bota, M.; Fichtner, F.; Fuest, K.; Lahmer, T.; Herrmann, J.; Meybohm, P.; Markou, N.; Vasileiadou, G.; Chrysanthopoulou, E.; Papamichalis, P.; Soultati, I.; Kalvit, K.; Myatra, S. N.; Krupa, I.; Tharwat, A.; Nichol, A.; Mccarthy, A.; Mahmoodpoor, A.; Tonetti, T.; Isoni, P.; Spadaro, S. |
| Publisher Information: | BMC |
| Publication Year: | 2022 |
| Collection: | Università degli Studi di Messina: IRIS |
| Subject Terms: | Adrenal Cortex Hormones; Adult; Anti-Bacterial Agents; COVID-19 Testing; Critical Illness; Humans; Intensive Care Units; Pandemics; COVID-19; Coinfection; Pneumonia; Bacterial; Viral |
| Description: | Background: The COVID-19 pandemic presented major challenges for critical care facilities worldwide. Infections which develop alongside or subsequent to viral pneumonitis are a challenge under sporadic and pandemic conditions; however, data have suggested that patterns of these differ between COVID-19 and other viral pneumonitides. This secondary analysis aimed to explore patterns of co-infection and intensive care unit-acquired infections (ICU-AI) and the relationship to use of corticosteroids in a large, international cohort of critically ill COVID-19 patients.Methods: This is a multicenter, international, observational study, including adult patients with PCR-confirmed COVID-19 diagnosis admitted to ICUs at the peak of wave one of COVID-19 (February 15th to May 15th, 2020). Data collected included investigator-assessed co-infection at ICU admission, infection acquired in ICU, infection with multi-drug resistant organisms (MDRO) and antibiotic use. Frequencies were compared by Pearson's Chi-squared and continuous variables by Mann-Whitney U test. Propensity score matching for variables associated with ICU-acquired infection was undertaken using R library MatchIT using the "full" matching method.Results: Data were available from 4994 patients. Bacterial co-infection at admission was detected in 716 patients (14%), whilst 85% of patients received antibiotics at that stage. ICU-AI developed in 2715 (54%). The most common ICU-AI was bacterial pneumonia (44% of infections), whilst 9% of patients developed fungal pneumonia; 25% of infections involved MDRO. Patients developing infections in ICU had greater antimicrobial exposure than those without such infections. Incident density (ICU-AI per 1000 ICU days) was in considerable excess of reports from pre-pandemic surveillance. Corticosteroid use was heterogenous between ICUs. In univariate analysis, 58% of patients receiving corticosteroids and 43% of those not receiving steroids developed ICU-AI. Adjusting for potential confounders in the propensity-matched cohort, ... |
| Document Type: | article in journal/newspaper |
| File Description: | ELETTRONICO |
| Language: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/35922860; info:eu-repo/semantics/altIdentifier/wos/WOS:000835683700002; volume:26; issue:1, Article Number 236; firstpage:1; lastpage:16; numberofpages:16; journal:CRITICAL CARE; https://hdl.handle.net/11570/3242569 |
| DOI: | 10.1186/s13054-022-04108-8 |
| Availability: | https://hdl.handle.net/11570/3242569; https://doi.org/10.1186/s13054-022-04108-8; https://ccforum.biomedcentral.com/articles/10.1186/s13054-022-04108-8 |
| Rights: | info:eu-repo/semantics/openAccess |
| Accession Number: | edsbas.A6942612 |
| Database: | BASE |