| Title: |
Novel polymorphisms in caspase-8 are associated with breast cancer risk in the California Teachers Study |
| Authors: |
Park, Hannah; Ziogas, Argyrios; Chang, Jenny; Desai, Bhumi; Bessonova, Leona; Garner, Chad; Lee, Eunjung; Neuhausen, Susan; Wang, Sophia; Ma, Huiyan; Clague, Jessica; Reynolds, Peggy; Lacey, James; Bernstein, Leslie; Anton-Culver, Hoda |
| Publisher Information: |
BioMed Central Ltd. |
| Publication Year: |
2016 |
| Collection: |
BioMed Central |
| Subject Terms: |
Breast cancer; Single nucleotide polymorphism; Caspase-8 |
| Description: |
Background The ability of tamoxifen and raloxifene to decrease breast cancer risk varies among different breast cancer subtypes. It is important to determine one’s subtype-specific breast cancer risk when considering chemoprevention. A number of single nucleotide polymorphisms (SNPs), including one in caspase-8 ( CASP8 ), have been previously associated with risk of developing breast cancer. Because caspase-8 is an important protein involved in receptor-mediated apoptosis whose activity is affected by estrogen, we hypothesized that additional SNPs in CASP8 could be associated with breast cancer risk, perhaps in a subtype-specific manner. Methods Twelve tagging SNPs of CASP8 were analyzed in a nested case control study (1,353 cases and 1,384 controls) of non-Hispanic white women participating in the California Teachers Study. Odds ratios (ORs) and 95 % confidence intervals (CIs) were calculated for each SNP using all, estrogen receptor (ER)-positive, ER-negative, human epidermal growth factor receptor 2 (HER2)-positive, and HER2-negative breast cancers as separate outcomes. Results Several SNPs were associated with all, ER-positive, and HER2-positive breast cancers; however, after correcting for multiple comparisons (i.e., p < 0.0008), only rs2293554 was statistically significantly associated with HER2-positive breast cancer (OR = 1.98, 95 % CI 1.34-2.92, uncorrected p = 0.0005). Conclusions While our results for CASP8 SNPs should be validated in other cohorts with subtype-specific information, we conclude that some SNPs in CASP8 are associated with subtype-specific breast cancer risk. This study contributes to our understanding of CASP8 SNPs and breast cancer risk by subtype. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
http://www.biomedcentral.com/1471-2407/16/14 |
| Availability: |
http://www.biomedcentral.com/1471-2407/16/14 |
| Rights: |
Copyright 2016 Park et al. |
| Accession Number: |
edsbas.A69A01BF |
| Database: |
BASE |