| Title: |
Effects of isometric resistance training on resting blood pressure: individual participant data meta-analysis. |
| Authors: |
Smart, Neil A.; Way, Damien; Carlson, Debra; Millar, Philip; McGowan, Cheri; Swaine, Ian; Baross, Anthony; Howden, Reuben; Ritti-Dias, Raphael; Wiles, Jim; Cornelissen, Véronique; Gordon, Ben; Taylor, Rod; Bleile, Bea |
| Source: |
Smart, N A, Way, D, Carlson, D, Millar, P, McGowan, C, Swaine, I, Baross, A, Howden, R, Ritti-Dias, R, Wiles, J, Cornelissen, V, Gordon, B, Taylor, R & Bleile, B 2019, 'Effects of isometric resistance training on resting blood pressure: individual participant data meta-analysis.', Journal of Hypertension, vol. 37, no. 10, pp. 1927–1938. https://doi.org/10.1097/HJH.0000000000002105 |
| Publication Year: |
2019 |
| Description: |
Background:Previous meta-analyses based on aggregate group-level data report antihypertensive effects of isometric resistance training (IRT). However, individual participant data meta-analyses provide more robust effect size estimates and permit examination of demographic and clinical variables on IRT effectiveness.Methods:We conducted a systematic search and individual participant data (IPD) analysis, using both a one-step and two-step approach, of controlled trials investigating at least 3 weeks of IRT on resting systolic, diastolic and mean arterial blood pressure.Results:Anonymized individual participant data were provided from 12 studies (14 intervention group comparisons) involving 326 participants (52.7% medicated for hypertension); 191 assigned to IRT and 135 controls, 25.2% of participants had diagnosed coronary artery disease. IRT intensity varied (8–30% MVC) and training duration ranged from 3 to 12 weeks. The IPD (one-step) meta-analysis showed a significant treatment effect for the exercise group participants experiencing a reduction in resting SBP of −6.22 mmHg (95% CI −7.75 to −4.68; P < 0.00001); DBP of −2.78 mmHg (95% CI −3.92 to −1.65; P = 0.002); and mean arterial blood pressure (MAP) of −4.12 mmHg (95% CI −5.39 to −2.85; P < 0.00001). The two-step approach yielded similar results for change in SBP −7.35 mmHg (−8.95 to −5.75; P < 0.00001), DBP MD −3.29 mmHg (95% CI −5.12 to −1.46; P = 0.0004) and MAP MD −4.63 mmHg (95% CI −6.18 to −3.09: P < 0.00001). Sub-analysis revealed that neither clinical, medication, nor demographic participant characteristics, or exercise program features, modified the IRT treatment effect.Conclusion:This individual patient analysis confirms a clinically meaningful and statistically significant effect of IRT on resting SBP, DBP and mean arterial blood pressure.Keywords: blood pressure, hypertension, individual patient data meta-analysis, isometric exercise |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISSN: |
0263-6352; 1473-5598 |
| Relation: |
info:eu-repo/semantics/altIdentifier/pissn/0263-6352; info:eu-repo/semantics/altIdentifier/eissn/1473-5598 |
| DOI: |
10.1097/HJH.0000000000002105 |
| Availability: |
https://pure.northampton.ac.uk/en/publications/b0f25129-1d38-4fd1-b144-77b92d527870; https://doi.org/10.1097/HJH.0000000000002105 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.A6CDDF89 |
| Database: |
BASE |